DegronMD

Uniprot ID: Q5VXU9

Source protein: Protein shortage in chiasmata 1 ortholog

Source gene: SHOC1

Class: LIG_APCC_ABBAyCdc20_2

Location: 1326:1332

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6143

ASA_SCORE: 71.4857

COIL: 0.7004

CONS_SCORE: 0.4154

DSS_SCORE: 0.2428

HELIX: 0.1231

FCONS_SCORE: 0.8507

RIG_SCORE: 0.7705

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L1337P	SIDM00513	Non-Small Cell Lung Carcinoma	GDSC	KGNLFTD	LIG_APCC_ABBAyCdc20_2	0.1944
p.L1337P	COR-L105	lung	COSMIC	KGNLFTD	LIG_APCC_ABBAyCdc20_2	0.1944
p.L1322W	SIDM01051	Ovarian Carcinoma	GDSC	KGNLFTD	LIG_APCC_ABBAyCdc20_2	0.2222
p.L1322W	EFO-27	ovary	COSMIC	KGNLFTD	LIG_APCC_ABBAyCdc20_2	0.2222
p.S1330T	HT55	large_intestine	COSMIC	KGNLFTD	LIG_APCC_ABBAyCdc20_2	0.7116
p.S1330A	HEC-1	endometrium	COSMIC	KGNLFTD	LIG_APCC_ABBAyCdc20_2	0.7588

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5VXU9	Protein shortage in chiasmata 1 ortholog	LIG_APCC_ABBAyCdc20_2	1326:1332	KGNLFTD	APC,CDC20,FZR1	0.6143	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons