DegronMD

Uniprot ID: Q5VXU9

Source protein: Protein shortage in chiasmata 1 ortholog

Source gene: SHOC1

Class: DEG_APCC_KENBOX_2

Location: 479:483

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8057

ASA_SCORE: 127.44

COIL: 0.8958

CONS_SCORE: 0.6174

DSS_SCORE: 0.5575

HELIX: 0.0726

FCONS_SCORE: 1.0168

RIG_SCORE: 0.7023

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G492R	SIDM00671	T-Cell Non-Hodgkin's Lymphoma	GDSC	KKENN	DEG_APCC_KENBOX_2	0.0833
p.G492R	HH	haematopoietic_and_lymphoid_tissue	COSMIC	KKENN	DEG_APCC_KENBOX_2	0.0833
p.F486Y	SIDM00671	T-Cell Non-Hodgkin's Lymphoma	GDSC	KKENN	DEG_APCC_KENBOX_2	0.25
p.F486Y	HH	haematopoietic_and_lymphoid_tissue	COSMIC	KKENN	DEG_APCC_KENBOX_2	0.25
p.P493L	SIDM01045	Endometrial Carcinoma	GDSC	KKENN	DEG_APCC_KENBOX_2	0.0556
p.P493L	EN	endometrium	COSMIC	KKENN	DEG_APCC_KENBOX_2	0.0556
p.N483T	SIDM00290	Gastric Carcinoma	GDSC	KKENN	DEG_APCC_KENBOX_2	0.5944
p.N483T	HGC-27	stomach	COSMIC	KKENN	DEG_APCC_KENBOX_2	0.5944
p.I476V	RS4-11	haematopoietic_and_lymphoid_tissue	COSMIC	KKENN	DEG_APCC_KENBOX_2	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P13378	Homeobox protein Hox-D8	DEG_APCC_KENBOX_2	253:257	KKENN	APC,CDC20,FZR1	0.5012	More...
P17481	Homeobox protein Hox-B8	DEG_APCC_KENBOX_2	202:206	KKENN	APC,CDC20,FZR1	0.8038	More...
P49454	Centromere protein F	DEG_APCC_KENBOX_2	485:489	KKENN	APC,CDC20,FZR1	0.9739	More...
Q17RS7	Flap endonuclease GEN homolog 1	DEG_APCC_KENBOX_2	882:886	KKENN	APC,CDC20,FZR1	0.8381	More...
Q5VV43	Dyslexia-associated protein KIAA0319	DEG_APCC_KENBOX_2	712:716	KKENN	APC,CDC20,FZR1	0.9185	More...
Q5VXU9	Protein shortage in chiasmata 1 ortholog	DEG_APCC_KENBOX_2	479:483	KKENN	APC,CDC20,FZR1	0.8057	More...
Q8IYD8	Fanconi anemia group M protein	DEG_APCC_KENBOX_2	867:871	KKENN	APC,CDC20,FZR1	0.9394	More...
Q9Y6Q9	Nuclear receptor coactivator 3	DEG_APCC_KENBOX_2	731:735	KKENN	APC,CDC20,FZR1	0.8256	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons