DegronMD

Uniprot ID: Q8IYD8

Source protein: Fanconi anemia group M protein

Source gene: FANCM

Class: DEG_APCC_KENBOX_2

Location: 867:871

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9394

ASA_SCORE: 123.2

COIL: 0.7492

CONS_SCORE: 0.3376

DSS_SCORE: 0.4462

HELIX: 0.2192

FCONS_SCORE: 1.0024

RIG_SCORE: 0.6908

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G873D	TCGA-17-Z053	LUAD	TCGA	KKENN	DEG_APCC_KENBOX_2	0.2778
p.Q865E	TCGA-25-2397	OV	TCGA	KKENN	DEG_APCC_KENBOX_2	0.2778
p.N871D	TCGA-AX-A05Z	UCEC	TCGA	KKENN	DEG_APCC_KENBOX_2	0.5821
p.D864G	TCGA-AX-A2HG	UCEC	TCGA	KKENN	DEG_APCC_KENBOX_2	0.25
p.D876H	TCGA-BP-5006	KIRC	TCGA	KKENN	DEG_APCC_KENBOX_2	0.1944
p.H872Y	TCGA-D3-A51E	SKCM	TCGA	KKENN	DEG_APCC_KENBOX_2	0.3056
p.G873S	TCGA-EB-A3XF	SKCM	TCGA	KKENN	DEG_APCC_KENBOX_2	0.2778
p.G873A	TCGA-EB-A3XF	SKCM	TCGA	KKENN	DEG_APCC_KENBOX_2	0.2778
p.S875P	DO7825	COAD	ICGC	KKENN	DEG_APCC_KENBOX_2	0.2222
p.D871Y	DO229031	LICA	ICGC	KKENN	DEG_APCC_KENBOX_2	0.7325
p.S858F	DO37911	SKCM	ICGC	KKENN	DEG_APCC_KENBOX_2	0.0833
p.S858F	ACH-002471	Primary	CCLE	KKENN	DEG_APCC_KENBOX_2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P13378	Homeobox protein Hox-D8	DEG_APCC_KENBOX_2	253:257	KKENN	APC,CDC20,FZR1	0.5012	More...
P17481	Homeobox protein Hox-B8	DEG_APCC_KENBOX_2	202:206	KKENN	APC,CDC20,FZR1	0.8038	More...
P49454	Centromere protein F	DEG_APCC_KENBOX_2	485:489	KKENN	APC,CDC20,FZR1	0.9739	More...
Q17RS7	Flap endonuclease GEN homolog 1	DEG_APCC_KENBOX_2	882:886	KKENN	APC,CDC20,FZR1	0.8381	More...
Q5VV43	Dyslexia-associated protein KIAA0319	DEG_APCC_KENBOX_2	712:716	KKENN	APC,CDC20,FZR1	0.9185	More...
Q5VXU9	Protein shortage in chiasmata 1 ortholog	DEG_APCC_KENBOX_2	479:483	KKENN	APC,CDC20,FZR1	0.8057	More...
Q8IYD8	Fanconi anemia group M protein	DEG_APCC_KENBOX_2	867:871	KKENN	APC,CDC20,FZR1	0.9394	More...
Q9Y6Q9	Nuclear receptor coactivator 3	DEG_APCC_KENBOX_2	731:735	KKENN	APC,CDC20,FZR1	0.8256	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons