DegronMD - Q8IYD8(FANCM)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E1157K	TCGA-17-Z010	LUAD	TCGA	ISETPLVS	DEG_SCF_FBW7_1	1167:1174	Mutation rewiring degron network	0.0556
p.G873D	TCGA-17-Z053	LUAD	TCGA	KKENN	DEG_APCC_KENBOX_2	867:871	Mutation rewiring degron network	0.2778
p.Q865E	TCGA-25-2397	OV	TCGA	KKENN	DEG_APCC_KENBOX_2	867:871	Mutation rewiring degron network	0.2778
p.S1363C	TCGA-4E-A92E	UCEC	TCGA	ILKTPDSS	DEG_SCF_FBW7_1	1357:1364	Mutation altering degron motif	0.643
p.L1182H	TCGA-55-6968	LUAD	TCGA	ISETPLVS	DEG_SCF_FBW7_1	1167:1174	Mutation rewiring degron network	0.1111
p.R1372I	TCGA-AJ-A3EL	UCEC	TCGA	ILKTPDSS	DEG_SCF_FBW7_1	1357:1364	Mutation rewiring degron network	0.1111
p.S954F	TCGA-AJ-A3QS	UCEC	TCGA	DSGYNS	DEG_SCF_TRCP1_1	943:948	Mutation rewiring degron network	0.1667
p.S954F	TCGA-D3-A51T	SKCM	TCGA	DSGYNS	DEG_SCF_TRCP1_1	943:948	Mutation rewiring degron network	0.1667
p.D943Y	TCGA-AJ-A5DW	UCEC	TCGA	DSGYNS	DEG_SCF_TRCP1_1	943:948	Mutation altering degron motif	0.7325
p.D943Y	TCGA-AX-A2HC	UCEC	TCGA	DSGYNS	DEG_SCF_TRCP1_1	943:948	Mutation altering degron motif	0.7325
p.N871D	TCGA-AX-A05Z	UCEC	TCGA	KKENN	DEG_APCC_KENBOX_2	867:871	Mutation altering degron motif	0.5821
p.D864G	TCGA-AX-A2HG	UCEC	TCGA	KKENN	DEG_APCC_KENBOX_2	867:871	Mutation rewiring degron network	0.25
p.V1368L	TCGA-AZ-4315	COAD	TCGA	ILKTPDSS	DEG_SCF_FBW7_1	1357:1364	Mutation rewiring degron network	0.2222
p.L1347F	TCGA-AZ-4681	COAD	TCGA	ILKTPDSS	DEG_SCF_FBW7_1	1357:1364	Mutation rewiring degron network	0.0556
p.A1166V	TCGA-B5-A11E	UCEC	TCGA	ISETPLVS	DEG_SCF_FBW7_1	1167:1174	Mutation rewiring degron network	0.3056
p.D876H	TCGA-BP-5006	KIRC	TCGA	KKENN	DEG_APCC_KENBOX_2	867:871	Mutation rewiring degron network	0.1944
p.H872Y	TCGA-D3-A51E	SKCM	TCGA	KKENN	DEG_APCC_KENBOX_2	867:871	Mutation rewiring degron network	0.3056
p.L1159V	TCGA-DB-A64X	LGG	TCGA	ISETPLVS	DEG_SCF_FBW7_1	1167:1174	Mutation rewiring degron network	0.1111
p.P1171H	TCGA-DF-A2KN	UCEC	TCGA	ISETPLVS	DEG_SCF_FBW7_1	1167:1174	Mutation altering degron motif	0.7694
p.K1164N	TCGA-DK-A6AW	BLCA	TCGA	ISETPLVS	DEG_SCF_FBW7_1	1167:1174	Mutation substituting flanking lysine	0.3611
p.G873S	TCGA-EB-A3XF	SKCM	TCGA	KKENN	DEG_APCC_KENBOX_2	867:871	Mutation rewiring degron network	0.2778
p.G873A	TCGA-EB-A3XF	SKCM	TCGA	KKENN	DEG_APCC_KENBOX_2	867:871	Mutation rewiring degron network	0.2778
p.S944C	TCGA-P3-A6T7	HNSC	TCGA	DSGYNS	DEG_SCF_TRCP1_1	943:948	Mutation altering degron motif	0.7541
p.S875P	DO7825	COAD	ICGC	KKENN	DEG_APCC_KENBOX_2	867:871	Mutation rewiring degron network	0.2222
p.E1359D	DO218031	GACA	ICGC	ILKTPDSS	DEG_SCF_FBW7_1	1357:1364	Mutation altering degron motif	0.6758
p.E1359D	DO218243	GACA	ICGC	ILKTPDSS	DEG_SCF_FBW7_1	1357:1364	Mutation altering degron motif	0.6758
p.D871Y	DO229031	LICA	ICGC	KKENN	DEG_APCC_KENBOX_2	867:871	Mutation altering degron motif	0.7325
p.R1178L	DO229038	LICA	ICGC	ISETPLVS	DEG_SCF_FBW7_1	1167:1174	Mutation rewiring degron network	0.2222
p.R1178L	DO23597	LUAD	ICGC	ISETPLVS	DEG_SCF_FBW7_1	1167:1174	Mutation rewiring degron network	0.2222
p.R945K	DO24900	LUAD	ICGC	DSGYNS	DEG_SCF_TRCP1_1	943:948	Mutation altering degron motif	0.7237
p.D948H	DO26638	LUSC	ICGC	DSGYNS	DEG_SCF_TRCP1_1	943:948	Mutation altering degron motif	0.7688
p.L935F	DO222363	MELA	ICGC	DSGYNS	DEG_SCF_TRCP1_1	943:948	Mutation rewiring degron network	0.1111
p.S1365F	DO222546	MELA	ICGC	ILKTPDSS	DEG_SCF_FBW7_1	1357:1364	Mutation rewiring degron network	0.3056
p.N1160T	DO28571	OV	ICGC	ISETPLVS	DEG_SCF_FBW7_1	1167:1174	Mutation rewiring degron network	0.1389
p.F937L	DO36556	READ	ICGC	DSGYNS	DEG_SCF_TRCP1_1	943:948	Mutation rewiring degron network	0.1667
p.D1179E	DO47337	SKCM	ICGC	ISETPLVS	DEG_SCF_FBW7_1	1167:1174	Mutation rewiring degron network	0.1944
p.S858F	DO37911	SKCM	ICGC	KKENN	DEG_APCC_KENBOX_2	867:871	Mutation rewiring degron network	0.0833
p.S858F	ACH-002471	Primary	CCLE	KKENN	DEG_APCC_KENBOX_2	867:871	Mutation rewiring degron network	0.0833
p.E1349K	DO51274	SKCM	ICGC	ILKTPDSS	DEG_SCF_FBW7_1	1357:1364	Mutation rewiring degron network	0.1111
p.R1170H	DO40884	UCEC	ICGC	ISETPLVS	DEG_SCF_FBW7_1	1167:1174	Mutation altering degron motif	0.8244
p.E938K	DO40884	UCEC	ICGC	DSGYNS	DEG_SCF_TRCP1_1	943:948	Mutation rewiring degron network	0.1944
p.E938K	ACH-000993	Endometrial/Uterine Cancer	CCLE	DSGYNS	DEG_SCF_TRCP1_1	943:948	Mutation rewiring degron network	0.1944
p.E940D	DO41572	UCEC	ICGC	DSGYNS	DEG_SCF_TRCP1_1	943:948	Mutation rewiring degron network	0.25
p.L937F	SIDM01112	Osteosarcoma	GDSC	DSGYNS	DEG_SCF_TRCP1_1	943:948	Mutation rewiring degron network	0.1667
p.S956L	SIDM00688	B-Cell Non-Hodgkin's Lymphoma	GDSC	DSGYNS	DEG_SCF_TRCP1_1	943:948	Mutation rewiring degron network	0.1111
p.S956L	JSC-1	haematopoietic and lymphoid tissue	COSMIC	DSGYNS	DEG_SCF_TRCP1_1	943:948	Mutation rewiring degron network	0.1111
p.L1183W	SIDM00575	Glioma	GDSC	ISETPLVS	DEG_SCF_FBW7_1	1167:1174	Mutation rewiring degron network	0.0833
p.L1183W	NMC-G1	central nervous system	COSMIC	ISETPLVS	DEG_SCF_FBW7_1	1167:1174	Mutation rewiring degron network	0.0833
p.I1357L	SIDM01611	Endometrial Carcinoma	GDSC	ILKTPDSS	DEG_SCF_FBW7_1	1357:1364	Mutation altering degron motif	0.6063
p.S954Y	SIDM01588	Endometrial Carcinoma	GDSC	DSGYNS	DEG_SCF_TRCP1_1	943:948	Mutation rewiring degron network	0.1667
p.D1179Y	ACH-000803	Lung Cancer	CCLE	ISETPLVS	DEG_SCF_FBW7_1	1167:1174	Mutation rewiring degron network	0.1944
p.D1179Y	COLO-668	lung	COSMIC	ISETPLVS	DEG_SCF_FBW7_1	1167:1174	Mutation rewiring degron network	0.1944
p.L1157W	NMC-G1	central nervous system	COSMIC	ISETPLVS	DEG_SCF_FBW7_1	1167:1174	Mutation rewiring degron network	0.0556

Kaplan plot for FANCM in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FANCM

UniProt ID: Q8IYD8

Entrez ID: 57697

Protein name: Fanconi anemia group M protein (Protein FACM) (EC 3.6.4.13) (ATP-dependent RNA helicase FANCM) (Fanconi anemia-associated polypeptide of 250 kDa) (FAAP250) (Protein Hef ortholog)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FANCM in