DegronMD

Uniprot ID: Q8IYD8

Source protein: Fanconi anemia group M protein

Source gene: FANCM

Class: DEG_SCF_TRCP1_1

Location: 943:948

E3 ligase: BTRC

DEGRON score: 0.8835

ASA_SCORE: 72.3667

COIL: 0.8023

CONS_SCORE: 0.3144

DSS_SCORE: 0.2855

HELIX: 0.1008

FCONS_SCORE: 0.9263

RIG_SCORE: 0.7254

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S954F	TCGA-AJ-A3QS	UCEC	TCGA	DSGYNS	DEG_SCF_TRCP1_1	0.1667
p.S954F	TCGA-D3-A51T	SKCM	TCGA	DSGYNS	DEG_SCF_TRCP1_1	0.1667
p.D943Y	TCGA-AJ-A5DW	UCEC	TCGA	DSGYNS	DEG_SCF_TRCP1_1	0.7325
p.D943Y	TCGA-AX-A2HC	UCEC	TCGA	DSGYNS	DEG_SCF_TRCP1_1	0.7325
p.S944C	TCGA-P3-A6T7	HNSC	TCGA	DSGYNS	DEG_SCF_TRCP1_1	0.7541
p.R945K	DO24900	LUAD	ICGC	DSGYNS	DEG_SCF_TRCP1_1	0.7237
p.D948H	DO26638	LUSC	ICGC	DSGYNS	DEG_SCF_TRCP1_1	0.7688
p.L935F	DO222363	MELA	ICGC	DSGYNS	DEG_SCF_TRCP1_1	0.1111
p.F937L	DO36556	READ	ICGC	DSGYNS	DEG_SCF_TRCP1_1	0.1667
p.E938K	DO40884	UCEC	ICGC	DSGYNS	DEG_SCF_TRCP1_1	0.1944
p.E938K	ACH-000993	Endometrial/Uterine Cancer	CCLE	DSGYNS	DEG_SCF_TRCP1_1	0.1944
p.E940D	DO41572	UCEC	ICGC	DSGYNS	DEG_SCF_TRCP1_1	0.25
p.L937F	SIDM01112	Osteosarcoma	GDSC	DSGYNS	DEG_SCF_TRCP1_1	0.1667
p.S956L	SIDM00688	B-Cell Non-Hodgkin's Lymphoma	GDSC	DSGYNS	DEG_SCF_TRCP1_1	0.1111
p.S956L	JSC-1	haematopoietic_and_lymphoid_tissue	COSMIC	DSGYNS	DEG_SCF_TRCP1_1	0.1111
p.S954Y	SIDM01588	Endometrial Carcinoma	GDSC	DSGYNS	DEG_SCF_TRCP1_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IYD8	Fanconi anemia group M protein	DEG_SCF_TRCP1_1	943:948	DSGYNS	BTRC	0.8835	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons