DegronMD

Uniprot ID: Q8IYD8

Source protein: Fanconi anemia group M protein

Source gene: FANCM

Class: DEG_SCF_FBW7_1

Location: 1357:1364

E3 ligase: FBXW7

DEGRON score: 0.9697

ASA_SCORE: 81.9625

COIL: 0.715

CONS_SCORE: 0.3567

DSS_SCORE: 0.4182

HELIX: 0.2658

FCONS_SCORE: 1.0154

RIG_SCORE: 0.7312

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1363C	TCGA-4E-A92E	UCEC	TCGA	ILKTPDSS	DEG_SCF_FBW7_1	0.643
p.R1372I	TCGA-AJ-A3EL	UCEC	TCGA	ILKTPDSS	DEG_SCF_FBW7_1	0.1111
p.V1368L	TCGA-AZ-4315	COAD	TCGA	ILKTPDSS	DEG_SCF_FBW7_1	0.2222
p.L1347F	TCGA-AZ-4681	COAD	TCGA	ILKTPDSS	DEG_SCF_FBW7_1	0.0556
p.E1359D	DO218031	GACA	ICGC	ILKTPDSS	DEG_SCF_FBW7_1	0.6758
p.E1359D	DO218243	GACA	ICGC	ILKTPDSS	DEG_SCF_FBW7_1	0.6758
p.S1365F	DO222546	MELA	ICGC	ILKTPDSS	DEG_SCF_FBW7_1	0.3056
p.E1349K	DO51274	SKCM	ICGC	ILKTPDSS	DEG_SCF_FBW7_1	0.1111
p.I1357L	SIDM01611	Endometrial Carcinoma	GDSC	ILKTPDSS	DEG_SCF_FBW7_1	0.6063

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IYD8	Fanconi anemia group M protein	DEG_SCF_FBW7_1	1357:1364	ILKTPDSS	FBXW7	0.9697	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons