DegronMD

Uniprot ID: Q8IYD8

Source protein: Fanconi anemia group M protein

Source gene: FANCM

Class: DEG_SCF_FBW7_1

Location: 1167:1174

E3 ligase: FBXW7

DEGRON score: 0.9555

ASA_SCORE: 75.9125

COIL: 0.7894

CONS_SCORE: 0.3327

DSS_SCORE: 0.2575

HELIX: 0.1179

FCONS_SCORE: 0.9667

RIG_SCORE: 0.7745

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E1157K	TCGA-17-Z010	LUAD	TCGA	ISETPLVS	DEG_SCF_FBW7_1	0.0556
p.L1182H	TCGA-55-6968	LUAD	TCGA	ISETPLVS	DEG_SCF_FBW7_1	0.1111
p.A1166V	TCGA-B5-A11E	UCEC	TCGA	ISETPLVS	DEG_SCF_FBW7_1	0.3056
p.L1159V	TCGA-DB-A64X	LGG	TCGA	ISETPLVS	DEG_SCF_FBW7_1	0.1111
p.P1171H	TCGA-DF-A2KN	UCEC	TCGA	ISETPLVS	DEG_SCF_FBW7_1	0.7694
p.K1164N	TCGA-DK-A6AW	BLCA	TCGA	ISETPLVS	DEG_SCF_FBW7_1	0.3611
p.R1178L	DO229038	LICA	ICGC	ISETPLVS	DEG_SCF_FBW7_1	0.2222
p.R1178L	DO23597	LUAD	ICGC	ISETPLVS	DEG_SCF_FBW7_1	0.2222
p.N1160T	DO28571	OV	ICGC	ISETPLVS	DEG_SCF_FBW7_1	0.1389
p.D1179E	DO47337	SKCM	ICGC	ISETPLVS	DEG_SCF_FBW7_1	0.1944
p.R1170H	DO40884	UCEC	ICGC	ISETPLVS	DEG_SCF_FBW7_1	0.8244
p.L1183W	SIDM00575	Glioma	GDSC	ISETPLVS	DEG_SCF_FBW7_1	0.0833
p.L1183W	NMC-G1	central_nervous_system	COSMIC	ISETPLVS	DEG_SCF_FBW7_1	0.0833
p.D1179Y	ACH-000803	Lung Cancer	CCLE	ISETPLVS	DEG_SCF_FBW7_1	0.1944
p.D1179Y	COLO-668	lung	COSMIC	ISETPLVS	DEG_SCF_FBW7_1	0.1944
p.L1157W	NMC-G1	central_nervous_system	COSMIC	ISETPLVS	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IYD8	Fanconi anemia group M protein	DEG_SCF_FBW7_1	1167:1174	ISETPLVS	FBXW7	0.9555	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons