DegronMD

Uniprot ID: P49454

Source protein: Centromere protein F

Source gene: CENPF

Class: DEG_APCC_KENBOX_2

Location: 485:489

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9739

ASA_SCORE: 114.9

COIL: 0.0314

CONS_SCORE: 0.6423

DSS_SCORE: 0.5561

HELIX: 0.9704

FCONS_SCORE: 1.1957

RIG_SCORE: 0.6789

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K485R	TCGA-56-7582	LUSC	TCGA	KKENN	DEG_APCC_KENBOX_2	0.6126
p.K485R	DO26976	LUSC	ICGC	KKENN	DEG_APCC_KENBOX_2	0.6126
p.S495C	TCGA-XF-AAMQ	BLCA	TCGA	KKENN	DEG_APCC_KENBOX_2	0.1667
p.S495C	DO51934	BLCA	ICGC	KKENN	DEG_APCC_KENBOX_2	0.1667
p.H494Q	DO230334	COCA	ICGC	KKENN	DEG_APCC_KENBOX_2	0.1944
p.H494Q	DO229010	COCA	ICGC	KKENN	DEG_APCC_KENBOX_2	0.1944
p.H494Q	DO229013	COCA	ICGC	KKENN	DEG_APCC_KENBOX_2	0.1944
p.H494Q	DO229505	LAML	ICGC	KKENN	DEG_APCC_KENBOX_2	0.1944
p.H494Q	DO228941	LICA	ICGC	KKENN	DEG_APCC_KENBOX_2	0.1944
p.H494Q	DO52365	LUSC	ICGC	KKENN	DEG_APCC_KENBOX_2	0.1944
p.A499S	DO228985	LICA	ICGC	KKENN	DEG_APCC_KENBOX_2	0.0556
p.N489D	SIDM00537	Colorectal Carcinoma	GDSC	KKENN	DEG_APCC_KENBOX_2	0.5821
p.N489D	ACH-000982	Colon/Colorectal Cancer	CCLE	KKENN	DEG_APCC_KENBOX_2	0.5821
p.N489D	ACH-001345	Colon/Colorectal Cancer	CCLE	KKENN	DEG_APCC_KENBOX_2	0.5821
p.N489D	GP5d	large_intestine	COSMIC	KKENN	DEG_APCC_KENBOX_2	0.5821

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P13378	Homeobox protein Hox-D8	DEG_APCC_KENBOX_2	253:257	KKENN	APC,CDC20,FZR1	0.5012	More...
P17481	Homeobox protein Hox-B8	DEG_APCC_KENBOX_2	202:206	KKENN	APC,CDC20,FZR1	0.8038	More...
P49454	Centromere protein F	DEG_APCC_KENBOX_2	485:489	KKENN	APC,CDC20,FZR1	0.9739	More...
Q17RS7	Flap endonuclease GEN homolog 1	DEG_APCC_KENBOX_2	882:886	KKENN	APC,CDC20,FZR1	0.8381	More...
Q5VV43	Dyslexia-associated protein KIAA0319	DEG_APCC_KENBOX_2	712:716	KKENN	APC,CDC20,FZR1	0.9185	More...
Q5VXU9	Protein shortage in chiasmata 1 ortholog	DEG_APCC_KENBOX_2	479:483	KKENN	APC,CDC20,FZR1	0.8057	More...
Q8IYD8	Fanconi anemia group M protein	DEG_APCC_KENBOX_2	867:871	KKENN	APC,CDC20,FZR1	0.9394	More...
Q9Y6Q9	Nuclear receptor coactivator 3	DEG_APCC_KENBOX_2	731:735	KKENN	APC,CDC20,FZR1	0.8256	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons