DegronMD

Uniprot ID: Q9Y6Q9

Source protein: Nuclear receptor coactivator 3

Source gene: NCOA3

Class: DEG_APCC_DBOX_1

Location: 1050:1058

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9634

ASA_SCORE: 87.3222

COIL: 0.2596

CONS_SCORE: 0.6335

DSS_SCORE: 0.4342

HELIX: 0.7287

FCONS_SCORE: 1.1053

RIG_SCORE: 0.781

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1051I	TCGA-06-0221	GBM	TCGA	ERALLDQLH	DEG_APCC_DBOX_1	0.8102
p.R1051I	DO13971	GBM	ICGC	ERALLDQLH	DEG_APCC_DBOX_1	0.8102
p.L1060F	TCGA-A7-A26H	BRCA	TCGA	ERALLDQLH	DEG_APCC_DBOX_1	0.2778
p.D1049Y	TCGA-AB-2806	LAML	TCGA	ERALLDQLH	DEG_APCC_DBOX_1	0.3056
p.D1049Y	DO21283	LAML	ICGC	ERALLDQLH	DEG_APCC_DBOX_1	0.3056
p.G1042V	DO23564	LUAD	ICGC	ERALLDQLH	DEG_APCC_DBOX_1	0.5556
p.L1044M	SIDM00874	Breast Carcinoma	GDSC	ERALLDQLH	DEG_APCC_DBOX_1	0.1667
p.L1044M	ACH-000223	Breast Cancer	CCLE	ERALLDQLH	DEG_APCC_DBOX_1	0.1667
p.L1044M	HCC1937	breast	COSMIC	ERALLDQLH	DEG_APCC_DBOX_1	0.1667
p.T1059A	SIDM00181	Bladder Carcinoma	GDSC	ERALLDQLH	DEG_APCC_DBOX_1	0.75
p.T1059A	ACH-002266	Bladder Cancer	CCLE	ERALLDQLH	DEG_APCC_DBOX_1	0.75
p.T1059A	LB831-BLC	urinary_tract	COSMIC	ERALLDQLH	DEG_APCC_DBOX_1	0.75
p.T1059N	SIDM01029	Esophageal Squamous Cell Carcinoma	GDSC	ERALLDQLH	DEG_APCC_DBOX_1	0.75
p.T1059N	ACH-000873	Esophageal Cancer	CCLE	ERALLDQLH	DEG_APCC_DBOX_1	0.75
p.T1059N	KYSE-270	oesophagus	COSMIC	ERALLDQLH	DEG_APCC_DBOX_1	0.75
p.E1050K	SIDM00118	Colorectal Carcinoma	GDSC	ERALLDQLH	DEG_APCC_DBOX_1	0.591
p.E1050K	ACH-001081	Colon/Colorectal Cancer	CCLE	ERALLDQLH	DEG_APCC_DBOX_1	0.591
p.E1050K	HCC2998	large_intestine	COSMIC	ERALLDQLH	DEG_APCC_DBOX_1	0.591
p.E1045K	HCC2998	large_intestine	COSMIC	ERALLDQLH	DEG_APCC_DBOX_1	0.1944
p.T1054N	KYSE-270	oesophagus	COSMIC	ERALLDQLH	DEG_APCC_DBOX_1	0.7055
p.T1054A	LB831-BLC	urinary_tract	COSMIC	ERALLDQLH	DEG_APCC_DBOX_1	0.7139

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y6Q9	Nuclear receptor coactivator 3	DEG_APCC_DBOX_1	1050:1058	ERALLDQLH	APC,CDC20,FZR1	0.9634	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons