DegronMD - Q8NEZ2(VPS37A)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L173F	TCGA-78-7158	LUAD	TCGA	VSSST	DEG_SPOP_SBC_1	179:183	Mutation rewiring degron network	0.1667
p.A136V	TCGA-AJ-A8CV	UCEC	TCGA	APTST	DEG_SPOP_SBC_1	131:135	Mutation rewiring degron network	0.3056
p.V179L	TCGA-B5-A3FA	UCEC	TCGA	VSSST	DEG_SPOP_SBC_1	179:183	Mutation altering degron motif	0.6765
p.P191S	TCGA-D3-A51G	SKCM	TCGA	VSSST	DEG_SPOP_SBC_1	179:183	Mutation rewiring degron network	0.1111
p.I170S	TCGA-IB-7651	PAAD	TCGA	VSSST	DEG_SPOP_SBC_1	179:183	Mutation rewiring degron network	0.0833
p.P191R	TCGA-R6-A6Y2	ESCA	TCGA	VSSST	DEG_SPOP_SBC_1	179:183	Mutation rewiring degron network	0.1111
p.P138L	TCGA-WE-A8ZX	SKCM	TCGA	APTST	DEG_SPOP_SBC_1	131:135	Mutation rewiring degron network	0.25
p.D185H	DO218986	BLCA	ICGC	VSSST	DEG_SPOP_SBC_1	179:183	Mutation rewiring degron network	0.2778
p.P131T	DO234278	ESAD	ICGC	APTST	DEG_SPOP_SBC_1	131:135	Mutation altering degron motif	0.7031
p.D185N	DO233694	GACA	ICGC	VSSST	DEG_SPOP_SBC_1	179:183	Mutation rewiring degron network	0.2778
p.P137T	DO22837	LIHC	ICGC	APTST	DEG_SPOP_SBC_1	131:135	Mutation rewiring degron network	0.2778
p.P135S	DO46657	PAAD	ICGC	APTST	DEG_SPOP_SBC_1	131:135	Mutation altering degron motif	0.6752
p.E140Q	DO51465	PACA	ICGC	APTST	DEG_SPOP_SBC_1	131:135	Mutation rewiring degron network	0.1944
p.P189L	DO37583	SKCM	ICGC	VSSST	DEG_SPOP_SBC_1	179:183	Mutation rewiring degron network	0.1667
p.P189S	DO37583	SKCM	ICGC	VSSST	DEG_SPOP_SBC_1	179:183	Mutation rewiring degron network	0.1667
p.S170L	DO37432	SKCM	ICGC	VSSST	DEG_SPOP_SBC_1	179:183	Mutation rewiring degron network	0.0833
p.S170L	DO51301	SKCM	ICGC	VSSST	DEG_SPOP_SBC_1	179:183	Mutation rewiring degron network	0.0833
p.G129C	DO37431	SKCM	ICGC	APTST	DEG_SPOP_SBC_1	131:135	Mutation rewiring degron network	0.2778
p.Q128K	DO47569	SKCM	ICGC	APTST	DEG_SPOP_SBC_1	131:135	Mutation rewiring degron network	0.25
p.S123F	DO52402	UCEC	ICGC	APTST	DEG_SPOP_SBC_1	131:135	Mutation rewiring degron network	0.1111
p.S127Y	DO42673	UCEC	ICGC	APTST	DEG_SPOP_SBC_1	131:135	Mutation rewiring degron network	0.2222
p.P144T	SIDM00789	Colorectal Carcinoma	GDSC	APTST	DEG_SPOP_SBC_1	131:135	Mutation rewiring degron network	0.0833
p.P144T	HCT-15	large intestine	COSMIC	APTST	DEG_SPOP_SBC_1	131:135	Mutation rewiring degron network	0.0833
p.Y141C	SIDM00252	Biliary Tract Carcinoma	GDSC	APTST	DEG_SPOP_SBC_1	131:135	Mutation rewiring degron network	0.1667
p.Y141C	ACH-001861	Gallbladder Cancer	CCLE	APTST	DEG_SPOP_SBC_1	131:135	Mutation rewiring degron network	0.1667
p.Y141C	TGBC1TKB	biliary tract	COSMIC	APTST	DEG_SPOP_SBC_1	131:135	Mutation rewiring degron network	0.1667
p.N143H	ACH-000976	Bile Duct Cancer	CCLE	APTST	DEG_SPOP_SBC_1	131:135	Mutation rewiring degron network	0.1111
p.A189G	ACH-001394	Breast Cancer	CCLE	VSSST	DEG_SPOP_SBC_1	179:183	Mutation rewiring degron network	0.1667

Kaplan plot for VPS37A in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

VPS37A

UniProt ID: Q8NEZ2

Entrez ID: 137492

Protein name: Vacuolar protein sorting-associated protein 37A (hVps37A) (ESCRT-I complex subunit VPS37A) (Hepatocellular carcinoma-related protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for VPS37A in