DegronMD - Q96IZ0(PAWR)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S264L	TCGA-2J-AABA	PAAD	TCGA	VSSST	DEG_SPOP_SBC_1	263:267	Mutation altering degron motif	0.6556
p.S264L	DO51659	PAAD	ICGC	VSSST	DEG_SPOP_SBC_1	263:267	Mutation altering degron motif	0.6556
p.E276G	TCGA-63-A5MP	LUSC	TCGA	VSSST	DEG_SPOP_SBC_1	263:267	Mutation rewiring degron network	0.0833
p.E276G	DO219157	LUSC	ICGC	VSSST	DEG_SPOP_SBC_1	263:267	Mutation rewiring degron network	0.0833
p.E269D	TCGA-A5-A0G2	UCEC	TCGA	VSSST	DEG_SPOP_SBC_1	263:267	Mutation rewiring degron network	0.2778
p.E269D	DO41235	UCEC	ICGC	VSSST	DEG_SPOP_SBC_1	263:267	Mutation rewiring degron network	0.2778
p.S266I	SIDM00441	Acute Myeloid Leukemia	GDSC	VSSST	DEG_SPOP_SBC_1	263:267	Mutation altering degron motif	0.7341
p.S266I	ACH-002273	Leukemia	CCLE	VSSST	DEG_SPOP_SBC_1	263:267	Mutation altering degron motif	0.7341
p.S266I	ML-2	haematopoietic and lymphoid tissue	COSMIC	VSSST	DEG_SPOP_SBC_1	263:267	Mutation altering degron motif	0.7341
p.S266G	SIDM01007	T-Lymphoblastic Leukemia	GDSC	VSSST	DEG_SPOP_SBC_1	263:267	Mutation altering degron motif	0.6993
p.S266G	ACH-002256	Leukemia	CCLE	VSSST	DEG_SPOP_SBC_1	263:267	Mutation altering degron motif	0.6993
p.S266G	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	VSSST	DEG_SPOP_SBC_1	263:267	Mutation altering degron motif	0.6993
p.S265T	SIDM00211	B-Lymphoblastic Leukemia	GDSC	VSSST	DEG_SPOP_SBC_1	263:267	Mutation altering degron motif	0.6005
p.S265T	ACH-002209	Leukemia	CCLE	VSSST	DEG_SPOP_SBC_1	263:267	Mutation altering degron motif	0.6005
p.S265T	ALL-PO	haematopoietic and lymphoid tissue	COSMIC	VSSST	DEG_SPOP_SBC_1	263:267	Mutation altering degron motif	0.6005
p.A256V	SIDM00217	Colorectal Carcinoma	GDSC	VSSST	DEG_SPOP_SBC_1	263:267	Mutation rewiring degron network	0.1389
p.A256V	SNU-1040	large intestine	COSMIC	VSSST	DEG_SPOP_SBC_1	263:267	Mutation rewiring degron network	0.1389
p.D255E	SIDM00008	Ovarian Carcinoma	GDSC	VSSST	DEG_SPOP_SBC_1	263:267	Mutation rewiring degron network	0.1111
p.D255E	ACH-000796	Ovarian Cancer	CCLE	VSSST	DEG_SPOP_SBC_1	263:267	Mutation rewiring degron network	0.1111
p.G260S	ACH-000246	Kidney Cancer	CCLE	VSSST	DEG_SPOP_SBC_1	263:267	Mutation rewiring degron network	0.25

Kaplan plot for PAWR in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PAWR

UniProt ID: Q96IZ0

Entrez ID: 5074

Protein name: PRKC apoptosis WT1 regulator protein (Prostate apoptosis response 4 protein) (Par-4)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PAWR in