DegronMD

Uniprot ID: Q96IZ0

Source protein: PRKC apoptosis WT1 regulator protein

Source gene: PAWR

Class: DEG_SPOP_SBC_1

Location: 263:267

E3 ligase: SPOP

DEGRON score: 0.7604

ASA_SCORE: 69.58

COIL: 0.6522

CONS_SCORE: 0.3067

DSS_SCORE: 0.4086

HELIX: 0.2928

FCONS_SCORE: 0.612

RIG_SCORE: 0.7218

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S264L	TCGA-2J-AABA	PAAD	TCGA	VSSST	DEG_SPOP_SBC_1	0.6556
p.S264L	DO51659	PAAD	ICGC	VSSST	DEG_SPOP_SBC_1	0.6556
p.E276G	TCGA-63-A5MP	LUSC	TCGA	VSSST	DEG_SPOP_SBC_1	0.0833
p.E276G	DO219157	LUSC	ICGC	VSSST	DEG_SPOP_SBC_1	0.0833
p.E269D	TCGA-A5-A0G2	UCEC	TCGA	VSSST	DEG_SPOP_SBC_1	0.2778
p.E269D	DO41235	UCEC	ICGC	VSSST	DEG_SPOP_SBC_1	0.2778
p.S266I	SIDM00441	Acute Myeloid Leukemia	GDSC	VSSST	DEG_SPOP_SBC_1	0.7341
p.S266I	ACH-002273	Leukemia	CCLE	VSSST	DEG_SPOP_SBC_1	0.7341
p.S266I	ML-2	haematopoietic_and_lymphoid_tissue	COSMIC	VSSST	DEG_SPOP_SBC_1	0.7341
p.S266G	SIDM01007	T-Lymphoblastic Leukemia	GDSC	VSSST	DEG_SPOP_SBC_1	0.6993
p.S266G	ACH-002256	Leukemia	CCLE	VSSST	DEG_SPOP_SBC_1	0.6993
p.S266G	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	VSSST	DEG_SPOP_SBC_1	0.6993
p.S265T	SIDM00211	B-Lymphoblastic Leukemia	GDSC	VSSST	DEG_SPOP_SBC_1	0.6005
p.S265T	ACH-002209	Leukemia	CCLE	VSSST	DEG_SPOP_SBC_1	0.6005
p.S265T	ALL-PO	haematopoietic_and_lymphoid_tissue	COSMIC	VSSST	DEG_SPOP_SBC_1	0.6005
p.A256V	SIDM00217	Colorectal Carcinoma	GDSC	VSSST	DEG_SPOP_SBC_1	0.1389
p.A256V	SNU-1040	large_intestine	COSMIC	VSSST	DEG_SPOP_SBC_1	0.1389
p.D255E	SIDM00008	Ovarian Carcinoma	GDSC	VSSST	DEG_SPOP_SBC_1	0.1111
p.D255E	ACH-000796	Ovarian Cancer	CCLE	VSSST	DEG_SPOP_SBC_1	0.1111
p.G260S	ACH-000246	Kidney Cancer	CCLE	VSSST	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60237	Protein phosphatase 1 regulatory subunit 12B	DEG_SPOP_SBC_1	574:578	VSSST	SPOP	0.9726	More...
O75179	Ankyrin repeat domain-containing protein 17	DEG_SPOP_SBC_1	2573:2577	VSSST	SPOP	0.768	More...
O75496	Geminin	DEG_SPOP_SBC_1	199:203	VSSST	SPOP	0.9991	More...
O95935	T-box transcription factor TBX18	DEG_SPOP_SBC_1	460:464	VSSST	SPOP	0.9891	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1797:1801	VSSST	SPOP	0.9347	More...
Q12951	Forkhead box protein I1	DEG_SPOP_SBC_1	222:226	VSSST	SPOP	0.9895	More...
Q13433	Zinc transporter ZIP6	DEG_SPOP_SBC_1	218:222	VSSST	SPOP	0.9963	More...
Q13516	Oligodendrocyte transcription factor 2	DEG_SPOP_SBC_1	39:43	VSSST	SPOP	0.9992	More...
Q2LD37	Transmembrane protein KIAA1109	DEG_SPOP_SBC_1	4029:4033	VSSST	SPOP	0.5866	More...
Q5CZC0	Fibrous sheath-interacting protein 2	DEG_SPOP_SBC_1	5734:5738	VSSST	SPOP	0.9977	More...
Q5T4S7	E3 ubiquitin-protein ligase UBR4	DEG_SPOP_SBC_1	2933:2937	VSSST	SPOP	0.996	More...
Q5T6F2	Ubiquitin-associated protein 2	DEG_SPOP_SBC_1	1005:1009	VSSST	SPOP	0.9988	More...
Q8NEZ2	Vacuolar protein sorting-associated protein 37A	DEG_SPOP_SBC_1	179:183	VSSST	SPOP	0.9741	More...
Q8WWM7	Ataxin-2-like protein	DEG_SPOP_SBC_1	835:839	VSSST	SPOP	0.9941	More...
Q96IZ0	PRKC apoptosis WT1 regulator protein	DEG_SPOP_SBC_1	263:267	VSSST	SPOP	0.7604	More...
Q9P1A6	Disks large-associated protein 2	DEG_SPOP_SBC_1	155:159	VSSST	SPOP	0.9548	More...
Q9UJT9	F-box/LRR-repeat protein 7	DEG_SPOP_SBC_1	23:27	VSSST	SPOP	0.9977	More...
Q9Y6Q9	Nuclear receptor coactivator 3	DEG_SPOP_SBC_1	659:663	VSSST	SPOP	0.9709	More...
Q9H195	Mucin-3B	DEG_SPOP_SBC_1	365:369	VSSST	SPOP	0.9057	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VSSST

Degron related mutations and impact score

Drug responses associated with PAWR mutations

All proteins holding degron of VSSST