DegronMD

Uniprot ID: O95935

Source protein: T-box transcription factor TBX18

Source gene: TBX18

Class: DEG_APCC_DBOX_1

Location: 565:573

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9993

ASA_SCORE: 69.0667

COIL: 0.8063

CONS_SCORE: 0.5886

DSS_SCORE: 0.5734

HELIX: 0.0716

FCONS_SCORE: 1.0616

RIG_SCORE: 0.7247

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H576L	TCGA-05-4390	LUAD	TCGA	DRQMLPPVE	DEG_APCC_DBOX_1	0.25
p.H576L	DO23562	LUAD	ICGC	DRQMLPPVE	DEG_APCC_DBOX_1	0.25
p.Q567H	TCGA-A5-A0G2	UCEC	TCGA	DRQMLPPVE	DEG_APCC_DBOX_1	0.647
p.Q567H	DO41235	UCEC	ICGC	DRQMLPPVE	DEG_APCC_DBOX_1	0.647
p.P571H	TCGA-BA-6869	HNSC	TCGA	DRQMLPPVE	DEG_APCC_DBOX_1	0.6583
p.P571H	DO14250	HNSC	ICGC	DRQMLPPVE	DEG_APCC_DBOX_1	0.6583
p.R566Q	TCGA-CD-8527	STAD	TCGA	DRQMLPPVE	DEG_APCC_DBOX_1	0.7329
p.R566Q	DO47739	STAD	ICGC	DRQMLPPVE	DEG_APCC_DBOX_1	0.7329
p.T564M	TCGA-CG-4465	STAD	TCGA	DRQMLPPVE	DEG_APCC_DBOX_1	0.3056
p.T564M	TCGA-CG-4474	STAD	TCGA	DRQMLPPVE	DEG_APCC_DBOX_1	0.3056
p.T564M	TCGA-EJ-5494	PRAD	TCGA	DRQMLPPVE	DEG_APCC_DBOX_1	0.3056
p.T564M	DO225278	BRCA	ICGC	DRQMLPPVE	DEG_APCC_DBOX_1	0.3056
p.T564M	DO227844	COCA	ICGC	DRQMLPPVE	DEG_APCC_DBOX_1	0.3056
p.T564M	DO228824	MALY	ICGC	DRQMLPPVE	DEG_APCC_DBOX_1	0.3056
p.T564M	DO36343	PRAD	ICGC	DRQMLPPVE	DEG_APCC_DBOX_1	0.3056
p.T564M	DO38535	STAD	ICGC	DRQMLPPVE	DEG_APCC_DBOX_1	0.3056
p.T564M	DO38627	STAD	ICGC	DRQMLPPVE	DEG_APCC_DBOX_1	0.3056
p.G556V	TCGA-D3-A1Q1	SKCM	TCGA	DRQMLPPVE	DEG_APCC_DBOX_1	0.0833
p.G556V	DO37445	SKCM	ICGC	DRQMLPPVE	DEG_APCC_DBOX_1	0.0833
p.P571S	TCGA-EB-A44O	SKCM	TCGA	DRQMLPPVE	DEG_APCC_DBOX_1	0.5641
p.P571S	DO47272	SKCM	ICGC	DRQMLPPVE	DEG_APCC_DBOX_1	0.5641
p.G574R	TCGA-FW-A3R5	SKCM	TCGA	DRQMLPPVE	DEG_APCC_DBOX_1	0.3056
p.G574R	DO222382	MELA	ICGC	DRQMLPPVE	DEG_APCC_DBOX_1	0.3056
p.G574R	DO37406	SKCM	ICGC	DRQMLPPVE	DEG_APCC_DBOX_1	0.3056
p.S579R	DO229041	LICA	ICGC	DRQMLPPVE	DEG_APCC_DBOX_1	0.1667
p.M568R	DO229459	SKCA	ICGC	DRQMLPPVE	DEG_APCC_DBOX_1	0.7521
p.P570S	SIDM00545	Melanoma	GDSC	DRQMLPPVE	DEG_APCC_DBOX_1	0.5641
p.P570S	ACH-000987	Skin Cancer	CCLE	DRQMLPPVE	DEG_APCC_DBOX_1	0.5641
p.P570S	Mewo	skin	COSMIC	DRQMLPPVE	DEG_APCC_DBOX_1	0.5641

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DRQMLPPVE

Degron related mutations and impact score

Drug responses associated with TBX18 mutations

All proteins holding degron of DRQMLPPVE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95935	T-box transcription factor TBX18	DEG_APCC_DBOX_1	565:573	DRQMLPPVE	APC,CDC20,FZR1	0.9993	More...