DegronMD - P12036(NEFH)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P906Q	TCGA-05-4382	LUAD	TCGA	EEAEDKKKVPTP	DEG_COP1_1	901:912	Mutation altering degron motif	0.7035
p.P906Q	DO24900	LUAD	ICGC	EEAEDKKKVPTP	DEG_COP1_1	901:912	Mutation altering degron motif	0.7035
p.P911T	TCGA-32-4209	GBM	TCGA	EEAEDKKKVPTP	DEG_COP1_1	901:912	Mutation altering degron motif	0.7031
p.P911T	TCGA-32-4209	GBM	TCGA	VPTPEKE	DEG_SCF_FBW7_2	909:915	Mutation altering degron motif	0.7031
p.P911T	DO13336	GBM	ICGC	EEAEDKKKVPTP	DEG_COP1_1	901:912	Mutation altering degron motif	0.7031
p.P911T	DO13336	GBM	ICGC	VPTPEKE	DEG_SCF_FBW7_2	909:915	Mutation altering degron motif	0.7031
p.A897D	TCGA-AA-3947	COAD	TCGA	EEAEDKKKVPTP	DEG_COP1_1	901:912	Mutation rewiring degron network	0.2222
p.A897D	DO8192	COAD	ICGC	EEAEDKKKVPTP	DEG_COP1_1	901:912	Mutation rewiring degron network	0.2222
p.V916A	TCGA-B5-A3FA	UCEC	TCGA	EEAEDKKKVPTP	DEG_COP1_1	901:912	Mutation rewiring degron network	0.2222
p.V916A	TCGA-B5-A3FA	UCEC	TCGA	VPTPEKE	DEG_SCF_FBW7_2	909:915	Mutation rewiring degron network	0.3056
p.V916A	DO52402	UCEC	ICGC	EEAEDKKKVPTP	DEG_COP1_1	901:912	Mutation rewiring degron network	0.2222
p.V916A	DO52402	UCEC	ICGC	VPTPEKE	DEG_SCF_FBW7_2	909:915	Mutation rewiring degron network	0.3056
p.E924K	TCGA-CA-6717	COAD	TCGA	VPTPEKE	DEG_SCF_FBW7_2	909:915	Mutation rewiring degron network	0.0833
p.E924K	DO8264	COAD	ICGC	VPTPEKE	DEG_SCF_FBW7_2	909:915	Mutation rewiring degron network	0.0833
p.E898K	TCGA-DS-A0VM	CESC	TCGA	EEAEDKKKVPTP	DEG_COP1_1	901:912	Mutation rewiring degron network	0.25
p.E898K	DO6258	CESC	ICGC	EEAEDKKKVPTP	DEG_COP1_1	901:912	Mutation rewiring degron network	0.25
p.D858N	TCGA-FW-A3R5	SKCM	TCGA	PATPKTE	DEG_SCF_FBW7_2	854:860	Mutation altering degron motif	0.6932
p.D858N	DO37406	SKCM	ICGC	PATPKTE	DEG_SCF_FBW7_2	854:860	Mutation altering degron motif	0.6932
p.E915K	TCGA-W3-A824	SKCM	TCGA	VPTPEKE	DEG_SCF_FBW7_2	909:915	Mutation altering degron motif	0.7022
p.E915K	DO51271	SKCM	ICGC	VPTPEKE	DEG_SCF_FBW7_2	909:915	Mutation altering degron motif	0.7022
p.E868K	TCGA-Z2-A8RT	SKCM	TCGA	PATPKTE	DEG_SCF_FBW7_2	854:860	Mutation rewiring degron network	0.1111
p.E868K	DO51301	SKCM	ICGC	PATPKTE	DEG_SCF_FBW7_2	854:860	Mutation rewiring degron network	0.1111
p.P904S	DO230346	COCA	ICGC	EEAEDKKKVPTP	DEG_COP1_1	901:912	Mutation altering degron motif	0.6752
p.R38S	DO227802	COCA	ICGC	AGSSS	DEG_SPOP_SBC_1	41:45	Mutation rewiring degron network	0.25
p.R64C	DO233941	GACA	ICGC	AASST	DEG_SPOP_SBC_1	70:74	Mutation rewiring degron network	0.1667
p.R64L	DO229028	LICA	ICGC	AASST	DEG_SPOP_SBC_1	70:74	Mutation rewiring degron network	0.1667
p.S49T	DO23218	LINC	ICGC	AGSSS	DEG_SPOP_SBC_1	41:45	Mutation rewiring degron network	0.2222
p.A70T	DO23278	LINC	ICGC	AASST	DEG_SPOP_SBC_1	70:74	Mutation altering degron motif	0.7139
p.E891D	DO228349	MALY	ICGC	EEAEDKKKVPTP	DEG_COP1_1	901:912	Mutation rewiring degron network	0.0556
p.E891D	SIDM00656	Burkitt's Lymphoma	GDSC	EEAEDKKKVPTP	DEG_COP1_1	901:912	Mutation rewiring degron network	0.0556
p.E891D	SIDM00641	Burkitt's Lymphoma	GDSC	EEAEDKKKVPTP	DEG_COP1_1	901:912	Mutation rewiring degron network	0.0556
p.E891D	ACH-000944	Lymphoma	CCLE	EEAEDKKKVPTP	DEG_COP1_1	901:912	Mutation rewiring degron network	0.0556
p.E891D	NAMALWA	haematopoietic and lymphoid tissue	COSMIC	EEAEDKKKVPTP	DEG_COP1_1	901:912	Mutation rewiring degron network	0.0556
p.T53M	DO228490	MALY	ICGC	AGSSS	DEG_SPOP_SBC_1	41:45	Mutation rewiring degron network	0.1111
p.T37A	DO219881	SKCA	ICGC	AGSSS	DEG_SPOP_SBC_1	41:45	Mutation rewiring degron network	0.2222
p.A71T	DO229229	THCA	ICGC	AASST	DEG_SPOP_SBC_1	70:74	Mutation altering degron motif	0.6028
p.G35D	SIDM01245	T-Lymphoblastic Leukemia	GDSC	AGSSS	DEG_SPOP_SBC_1	41:45	Mutation rewiring degron network	0.1667
p.K867N	SIDM00493	Other Solid Cancers	GDSC	PATPKTE	DEG_SCF_FBW7_2	854:860	Mutation substituting flanking lysine	0.25
p.S43F	ACH-000975	Lung Cancer	CCLE	AGSSS	DEG_SPOP_SBC_1	41:45	Mutation altering degron motif	0.9093
p.E855D	ACH-001232	Brain Cancer	CCLE	PATPKTE	DEG_SCF_FBW7_2	854:860	Mutation altering degron motif	0.6758
p.S63G	ACH-001329	Brain Cancer	CCLE	AASST	DEG_SPOP_SBC_1	70:74	Mutation blocking phosphorylation signal	0.5833
p.E895K	ACH-001521	Skin Cancer	CCLE	EEAEDKKKVPTP	DEG_COP1_1	901:912	Mutation blocking ubiquitination signal	0.6111
p.D919N	ACH-001567	Skin Cancer	CCLE	EEAEDKKKVPTP	DEG_COP1_1	901:912	Mutation substituting flanking lysine	0.25
p.D919N	ACH-001567	Skin Cancer	CCLE	VPTPEKE	DEG_SCF_FBW7_2	909:915	Mutation substituting flanking lysine	0.3333

Kaplan plot for NEFH in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NEFH

UniProt ID: P12036

Entrez ID: 4744

Protein name: Neurofilament heavy polypeptide (NF-H) (200 kDa neurofilament protein) (Neurofilament triplet H protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NEFH in