DegronMD

Uniprot ID: P12036

Source protein: Neurofilament heavy polypeptide

Source gene: NEFH

Class: DEG_SCF_FBW7_2

Location: 909:915

E3 ligase: FBXW7

DEGRON score: 0.9967

ASA_SCORE: 116.8857

COIL: 0.9484

CONS_SCORE: 0.7544

DSS_SCORE: 0.5903

HELIX: 0.0313

FCONS_SCORE: 1.0018

RIG_SCORE: 0.6276

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P911T	TCGA-32-4209	GBM	TCGA	VPTPEKE	DEG_SCF_FBW7_2	0.7031
p.P911T	DO13336	GBM	ICGC	VPTPEKE	DEG_SCF_FBW7_2	0.7031
p.V916A	TCGA-B5-A3FA	UCEC	TCGA	VPTPEKE	DEG_SCF_FBW7_2	0.3056
p.V916A	DO52402	UCEC	ICGC	VPTPEKE	DEG_SCF_FBW7_2	0.3056
p.E924K	TCGA-CA-6717	COAD	TCGA	VPTPEKE	DEG_SCF_FBW7_2	0.0833
p.E924K	DO8264	COAD	ICGC	VPTPEKE	DEG_SCF_FBW7_2	0.0833
p.E915K	TCGA-W3-A824	SKCM	TCGA	VPTPEKE	DEG_SCF_FBW7_2	0.7022
p.E915K	DO51271	SKCM	ICGC	VPTPEKE	DEG_SCF_FBW7_2	0.7022
p.D919N	ACH-001567	Skin Cancer	CCLE	VPTPEKE	DEG_SCF_FBW7_2	0.3333

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P12036	Neurofilament heavy polypeptide	DEG_SCF_FBW7_2	909:915	VPTPEKE	FBXW7	0.9967	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons