DegronMD

Uniprot ID: P12036

Source protein: Neurofilament heavy polypeptide

Source gene: NEFH

Class: DEG_COP1_1

Location: 901:912

E3 ligase: COP1

DEGRON score: 0.9899

ASA_SCORE: 111.8583

COIL: 0.818

CONS_SCORE: 0.7504

DSS_SCORE: 0.5822

HELIX: 0.1733

FCONS_SCORE: 1.008

RIG_SCORE: 0.6382

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P906Q	TCGA-05-4382	LUAD	TCGA	EEAEDKKKVPTP	DEG_COP1_1	0.7035
p.P906Q	DO24900	LUAD	ICGC	EEAEDKKKVPTP	DEG_COP1_1	0.7035
p.P911T	TCGA-32-4209	GBM	TCGA	EEAEDKKKVPTP	DEG_COP1_1	0.7031
p.P911T	DO13336	GBM	ICGC	EEAEDKKKVPTP	DEG_COP1_1	0.7031
p.A897D	TCGA-AA-3947	COAD	TCGA	EEAEDKKKVPTP	DEG_COP1_1	0.2222
p.A897D	DO8192	COAD	ICGC	EEAEDKKKVPTP	DEG_COP1_1	0.2222
p.V916A	TCGA-B5-A3FA	UCEC	TCGA	EEAEDKKKVPTP	DEG_COP1_1	0.2222
p.V916A	DO52402	UCEC	ICGC	EEAEDKKKVPTP	DEG_COP1_1	0.2222
p.E898K	TCGA-DS-A0VM	CESC	TCGA	EEAEDKKKVPTP	DEG_COP1_1	0.25
p.E898K	DO6258	CESC	ICGC	EEAEDKKKVPTP	DEG_COP1_1	0.25
p.P904S	DO230346	COCA	ICGC	EEAEDKKKVPTP	DEG_COP1_1	0.6752
p.E891D	DO228349	MALY	ICGC	EEAEDKKKVPTP	DEG_COP1_1	0.0556
p.E891D	SIDM00656	Burkitt's Lymphoma	GDSC	EEAEDKKKVPTP	DEG_COP1_1	0.0556
p.E891D	SIDM00641	Burkitt's Lymphoma	GDSC	EEAEDKKKVPTP	DEG_COP1_1	0.0556
p.E891D	ACH-000944	Lymphoma	CCLE	EEAEDKKKVPTP	DEG_COP1_1	0.0556
p.E891D	NAMALWA	haematopoietic_and_lymphoid_tissue	COSMIC	EEAEDKKKVPTP	DEG_COP1_1	0.0556
p.E895K	ACH-001521	Skin Cancer	CCLE	EEAEDKKKVPTP	DEG_COP1_1	0.6111
p.D919N	ACH-001567	Skin Cancer	CCLE	EEAEDKKKVPTP	DEG_COP1_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P12036	Neurofilament heavy polypeptide	DEG_COP1_1	901:912	EEAEDKKKVPTP	COP1	0.9899	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons