DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
PATPKTE
Uniprot ID:
P12036
Source protein:
Neurofilament heavy polypeptide
Source gene:
NEFH
Class:
DEG_SCF_FBW7_2
Location:
854:860
E3 ligase:
FBXW7
DEGRON score:
0.9515
ASA_SCORE:
109.4143
COIL:
0.9576
CONS_SCORE:
0.7612
DSS_SCORE:
0.665
HELIX:
0.0303
FCONS_SCORE:
1.0126
RIG_SCORE:
0.5722
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.D858N
TCGA-FW-A3R5
SKCM
TCGA
PATPKTE
DEG_SCF_FBW7_2
0.6932
p.D858N
DO37406
SKCM
ICGC
PATPKTE
DEG_SCF_FBW7_2
0.6932
p.E855D
ACH-001232
Brain Cancer
CCLE
PATPKTE
DEG_SCF_FBW7_2
0.6758
p.K867N
SIDM00493
Other Solid Cancers
GDSC
PATPKTE
DEG_SCF_FBW7_2
0.25
p.E868K
TCGA-Z2-A8RT
SKCM
TCGA
PATPKTE
DEG_SCF_FBW7_2
0.1111
p.E868K
DO51301
SKCM
ICGC
PATPKTE
DEG_SCF_FBW7_2
0.1111
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Drug responses associated with NEFH mutations
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Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
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All proteins holding degron of PATPKTE
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P12036
Neurofilament heavy polypeptide
DEG_SCF_FBW7_2
854:860
PATPKTE
FBXW7
0.9515
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