DegronMD

Uniprot ID: P12036

Source protein: Neurofilament heavy polypeptide

Source gene: NEFH

Class: DEG_SCF_FBW7_2

Location: 854:860

E3 ligase: FBXW7

DEGRON score: 0.9515

ASA_SCORE: 109.4143

COIL: 0.9576

CONS_SCORE: 0.7612

DSS_SCORE: 0.665

HELIX: 0.0303

FCONS_SCORE: 1.0126

RIG_SCORE: 0.5722

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D858N	TCGA-FW-A3R5	SKCM	TCGA	PATPKTE	DEG_SCF_FBW7_2	0.6932
p.D858N	DO37406	SKCM	ICGC	PATPKTE	DEG_SCF_FBW7_2	0.6932
p.E868K	TCGA-Z2-A8RT	SKCM	TCGA	PATPKTE	DEG_SCF_FBW7_2	0.1111
p.E868K	DO51301	SKCM	ICGC	PATPKTE	DEG_SCF_FBW7_2	0.1111
p.K867N	SIDM00493	Other Solid Cancers	GDSC	PATPKTE	DEG_SCF_FBW7_2	0.25
p.E855D	ACH-001232	Brain Cancer	CCLE	PATPKTE	DEG_SCF_FBW7_2	0.6758

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P12036	Neurofilament heavy polypeptide	DEG_SCF_FBW7_2	854:860	PATPKTE	FBXW7	0.9515	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons