DegronMD - Q9HAF1(MEAF6)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E21K	TCGA-DA-A3F8	SKCM	TCGA	TRRELAELV	DEG_APCC_DBOX_1	15:23	Mutation altering degron motif	0.591
p.E21K	DO37418	SKCM	ICGC	TRRELAELV	DEG_APCC_DBOX_1	15:23	Mutation altering degron motif	0.591
p.R17L	TCGA-ER-A19P	SKCM	TCGA	TRRELAELV	DEG_APCC_DBOX_1	15:23	Mutation altering degron motif	0.7316
p.R17L	DO47623	SKCM	ICGC	TRRELAELV	DEG_APCC_DBOX_1	15:23	Mutation altering degron motif	0.7316
p.S160F	TCGA-FI-A2D0	UCEC	TCGA	AASST	DEG_SPOP_SBC_1	155:159	Mutation blocking phosphorylation signal	0.75
p.S160F	DO43891	UCEC	ICGC	AASST	DEG_SPOP_SBC_1	155:159	Mutation blocking phosphorylation signal	0.75
p.P13T	TCGA-O2-A52N	LUSC	TCGA	TRRELAELV	DEG_APCC_DBOX_1	15:23	Mutation rewiring degron network	0.2778
p.P13T	DO219217	LUSC	ICGC	TRRELAELV	DEG_APCC_DBOX_1	15:23	Mutation rewiring degron network	0.2778
p.T32K	DO228974	LICA	ICGC	TRRELAELV	DEG_APCC_DBOX_1	15:23	Mutation rewiring degron network	0.0833
p.P9A	SIDM02035	Colorectal Carcinoma	GDSC	TRRELAELV	DEG_APCC_DBOX_1	15:23	Mutation rewiring degron network	0.1667
p.T32A	SIDM00664	Pancreatic Carcinoma	GDSC	TRRELAELV	DEG_APCC_DBOX_1	15:23	Mutation rewiring degron network	0.0833
p.T32A	ACH-000178	Pancreatic Cancer	CCLE	TRRELAELV	DEG_APCC_DBOX_1	15:23	Mutation rewiring degron network	0.0833
p.T32A	Hs766T	pancreas	COSMIC	TRRELAELV	DEG_APCC_DBOX_1	15:23	Mutation rewiring degron network	0.0833
p.A7T	SIDM00845	Burkitt's Lymphoma	GDSC	TRRELAELV	DEG_APCC_DBOX_1	15:23	Mutation rewiring degron network	0.1111
p.P10S	SIDM00143	Small Cell Lung Carcinoma	GDSC	TRRELAELV	DEG_APCC_DBOX_1	15:23	Mutation rewiring degron network	0.1944
p.P10S	ACH-000803	Lung Cancer	CCLE	TRRELAELV	DEG_APCC_DBOX_1	15:23	Mutation rewiring degron network	0.1944
p.A20E	SIDM00250	Esophageal Squamous Cell Carcinoma	GDSC	TRRELAELV	DEG_APCC_DBOX_1	15:23	Mutation altering degron motif	0.659
p.A20E	ACH-000917	Esophageal Cancer	CCLE	TRRELAELV	DEG_APCC_DBOX_1	15:23	Mutation altering degron motif	0.659
p.S166N	SIDM00500	Colorectal Carcinoma	GDSC	AASST	DEG_SPOP_SBC_1	155:159	Mutation rewiring degron network	0.1389
p.A155P	SIDM01764	Non-Small Cell Lung Carcinoma	GDSC	AASST	DEG_SPOP_SBC_1	155:159	Mutation altering degron motif	0.6392
p.A155P	ACH-000813	Lung Cancer	CCLE	AASST	DEG_SPOP_SBC_1	155:159	Mutation altering degron motif	0.6392
p.A155P	ACH-001521	Skin Cancer	CCLE	AASST	DEG_SPOP_SBC_1	155:159	Mutation altering degron motif	0.6392
p.T10A	Hs766T	pancreas	COSMIC	TRRELAELV	DEG_APCC_DBOX_1	15:23	Mutation rewiring degron network	0.1944
p.N151H	HCC2998	large intestine	COSMIC	AASST	DEG_SPOP_SBC_1	155:159	Mutation substituting flanking lysine	0.3333

Kaplan plot for MEAF6 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MEAF6

UniProt ID: Q9HAF1

Entrez ID: 64769

Protein name: Chromatin modification-related protein MEAF6 (MYST/Esa1-associated factor 6) (Esa1-associated factor 6 homolog) (Protein EAF6 homolog) (hEAF6) (Sarcoma antigen NY-SAR-91)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MEAF6 in