DegronMD

Uniprot ID: Q9HAF1

Source protein: Chromatin modification-related protein MEAF6

Source gene: MEAF6

Class: DEG_APCC_DBOX_1

Location: 15:23

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7996

ASA_SCORE: 69.8667

COIL: 0.0163

CONS_SCORE: 0.6278

DSS_SCORE: 0.469

HELIX: 0.9824

FCONS_SCORE: 1.2245

RIG_SCORE: 0.7929

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E21K	TCGA-DA-A3F8	SKCM	TCGA	TRRELAELV	DEG_APCC_DBOX_1	0.591
p.E21K	DO37418	SKCM	ICGC	TRRELAELV	DEG_APCC_DBOX_1	0.591
p.R17L	TCGA-ER-A19P	SKCM	TCGA	TRRELAELV	DEG_APCC_DBOX_1	0.7316
p.R17L	DO47623	SKCM	ICGC	TRRELAELV	DEG_APCC_DBOX_1	0.7316
p.P13T	TCGA-O2-A52N	LUSC	TCGA	TRRELAELV	DEG_APCC_DBOX_1	0.2778
p.P13T	DO219217	LUSC	ICGC	TRRELAELV	DEG_APCC_DBOX_1	0.2778
p.T32K	DO228974	LICA	ICGC	TRRELAELV	DEG_APCC_DBOX_1	0.0833
p.P9A	SIDM02035	Colorectal Carcinoma	GDSC	TRRELAELV	DEG_APCC_DBOX_1	0.1667
p.T32A	SIDM00664	Pancreatic Carcinoma	GDSC	TRRELAELV	DEG_APCC_DBOX_1	0.0833
p.T32A	ACH-000178	Pancreatic Cancer	CCLE	TRRELAELV	DEG_APCC_DBOX_1	0.0833
p.T32A	Hs766T	pancreas	COSMIC	TRRELAELV	DEG_APCC_DBOX_1	0.0833
p.A7T	SIDM00845	Burkitt's Lymphoma	GDSC	TRRELAELV	DEG_APCC_DBOX_1	0.1111
p.P10S	SIDM00143	Small Cell Lung Carcinoma	GDSC	TRRELAELV	DEG_APCC_DBOX_1	0.1944
p.P10S	ACH-000803	Lung Cancer	CCLE	TRRELAELV	DEG_APCC_DBOX_1	0.1944
p.A20E	SIDM00250	Esophageal Squamous Cell Carcinoma	GDSC	TRRELAELV	DEG_APCC_DBOX_1	0.659
p.A20E	ACH-000917	Esophageal Cancer	CCLE	TRRELAELV	DEG_APCC_DBOX_1	0.659
p.T10A	Hs766T	pancreas	COSMIC	TRRELAELV	DEG_APCC_DBOX_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HAF1	Chromatin modification-related protein MEAF6	DEG_APCC_DBOX_1	15:23	TRRELAELV	APC,CDC20,FZR1	0.7996	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons