DegronMD - Q9BZZ2(SIGLEC1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G426R	TCGA-81-5911	GBM	TCGA	PPLTPVLT	DEG_SCF_FBW7_1	411:418	Mutation rewiring degron network	0.1111
p.G426R	DO13546	GBM	ICGC	PPLTPVLT	DEG_SCF_FBW7_1	411:418	Mutation rewiring degron network	0.1111
p.G557C	TCGA-AA-3510	COAD	TCGA	AASST	DEG_SPOP_SBC_1	564:568	Mutation rewiring degron network	0.1389
p.G557C	DO7783	COAD	ICGC	AASST	DEG_SPOP_SBC_1	564:568	Mutation rewiring degron network	0.1389
p.P415S	TCGA-D3-A3C3	SKCM	TCGA	PPLTPVLT	DEG_SCF_FBW7_1	411:418	Mutation altering degron motif	0.6752
p.P415S	DO47667	SKCM	ICGC	PPLTPVLT	DEG_SCF_FBW7_1	411:418	Mutation altering degron motif	0.6752
p.R578Q	TCGA-D7-A747	STAD	TCGA	AASST	DEG_SPOP_SBC_1	564:568	Mutation rewiring degron network	0.0556
p.R578Q	DO51735	STAD	ICGC	AASST	DEG_SPOP_SBC_1	564:568	Mutation rewiring degron network	0.0556
p.R576W	TCGA-DA-A960	SKCM	TCGA	AASST	DEG_SPOP_SBC_1	564:568	Mutation rewiring degron network	0.1111
p.R576W	DO219482	SKCM	ICGC	AASST	DEG_SPOP_SBC_1	564:568	Mutation rewiring degron network	0.1111
p.R576W	SIDM01106	Melanoma	GDSC	AASST	DEG_SPOP_SBC_1	564:568	Mutation rewiring degron network	0.1111
p.A564S	TCGA-DD-AACE	LIHC	TCGA	AASST	DEG_SPOP_SBC_1	564:568	Mutation altering degron motif	0.7588
p.A564S	DO52200	LIHC	ICGC	AASST	DEG_SPOP_SBC_1	564:568	Mutation altering degron motif	0.7588
p.P556L	TCGA-ER-A19G	SKCM	TCGA	AASST	DEG_SPOP_SBC_1	564:568	Mutation rewiring degron network	0.1111
p.P556L	DO47284	SKCM	ICGC	AASST	DEG_SPOP_SBC_1	564:568	Mutation rewiring degron network	0.1111
p.A419T	TCGA-FI-A2D5	UCEC	TCGA	PPLTPVLT	DEG_SCF_FBW7_1	411:418	Mutation rewiring degron network	0.3056
p.A419T	DO41331	UCEC	ICGC	PPLTPVLT	DEG_SCF_FBW7_1	411:418	Mutation rewiring degron network	0.3056
p.L560I	TCGA-IB-7651	PAAD	TCGA	AASST	DEG_SPOP_SBC_1	564:568	Mutation rewiring degron network	0.2222
p.L560I	DO46657	PAAD	ICGC	AASST	DEG_SPOP_SBC_1	564:568	Mutation rewiring degron network	0.2222
p.P412S	TCGA-XK-AAIW	PRAD	TCGA	PPLTPVLT	DEG_SCF_FBW7_1	411:418	Mutation altering degron motif	0.5641
p.P412S	DO51407	PRAD	ICGC	PPLTPVLT	DEG_SCF_FBW7_1	411:418	Mutation altering degron motif	0.5641
p.P556S	DO224897	BRCA	ICGC	AASST	DEG_SPOP_SBC_1	564:568	Mutation rewiring degron network	0.1111
p.S558I	DO222762	COCA	ICGC	AASST	DEG_SPOP_SBC_1	564:568	Mutation rewiring degron network	0.1667
p.P411L	DO234222	ESAD	ICGC	PPLTPVLT	DEG_SCF_FBW7_1	411:418	Mutation altering degron motif	0.6471
p.A570T	DO218547	GACA	ICGC	AASST	DEG_SPOP_SBC_1	564:568	Mutation rewiring degron network	0.2778
p.A570T	DO233624	GACA	ICGC	AASST	DEG_SPOP_SBC_1	564:568	Mutation rewiring degron network	0.2778
p.R578W	DO233693	GACA	ICGC	AASST	DEG_SPOP_SBC_1	564:568	Mutation rewiring degron network	0.0556
p.R578W	ACH-000109	Lung Cancer	CCLE	AASST	DEG_SPOP_SBC_1	564:568	Mutation rewiring degron network	0.0556
p.A419P	DO228986	LICA	ICGC	PPLTPVLT	DEG_SCF_FBW7_1	411:418	Mutation rewiring degron network	0.3056
p.L417M	DO229041	LICA	ICGC	PPLTPVLT	DEG_SCF_FBW7_1	411:418	Mutation altering degron motif	0.5999
p.V416F	DO232761	PBCA	ICGC	PPLTPVLT	DEG_SCF_FBW7_1	411:418	Mutation altering degron motif	0.5957
p.A577S	ACH-002021	Endometrial/Uterine Cancer	CCLE	AASST	DEG_SPOP_SBC_1	564:568	Mutation rewiring degron network	0.0833

Kaplan plot for SIGLEC1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SIGLEC1

UniProt ID: Q9BZZ2

Entrez ID: 6614

Protein name: Sialoadhesin (Sialic acid-binding Ig-like lectin 1) (Siglec-1) (CD antigen CD169)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SIGLEC1 in