DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
PPLTPVLT
Uniprot ID:
Q9BZZ2
Source protein:
Sialoadhesin
Source gene:
SIGLEC1
Class:
DEG_SCF_FBW7_1
Location:
411:418
E3 ligase:
FBXW7
DEGRON score:
0.6204
ASA_SCORE:
79.75
COIL:
0.8066
CONS_SCORE:
0.6873
DSS_SCORE:
0.1155
HELIX:
0.0153
FCONS_SCORE:
0.9617
RIG_SCORE:
0.8353
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.P415S
TCGA-D3-A3C3
SKCM
TCGA
PPLTPVLT
DEG_SCF_FBW7_1
0.6752
p.P415S
DO47667
SKCM
ICGC
PPLTPVLT
DEG_SCF_FBW7_1
0.6752
p.P411L
DO234222
ESAD
ICGC
PPLTPVLT
DEG_SCF_FBW7_1
0.6471
p.L417M
DO229041
LICA
ICGC
PPLTPVLT
DEG_SCF_FBW7_1
0.5999
p.V416F
DO232761
PBCA
ICGC
PPLTPVLT
DEG_SCF_FBW7_1
0.5957
p.P412S
TCGA-XK-AAIW
PRAD
TCGA
PPLTPVLT
DEG_SCF_FBW7_1
0.5641
p.P412S
DO51407
PRAD
ICGC
PPLTPVLT
DEG_SCF_FBW7_1
0.5641
p.A419T
TCGA-FI-A2D5
UCEC
TCGA
PPLTPVLT
DEG_SCF_FBW7_1
0.3056
p.A419T
DO41331
UCEC
ICGC
PPLTPVLT
DEG_SCF_FBW7_1
0.3056
p.A419P
DO228986
LICA
ICGC
PPLTPVLT
DEG_SCF_FBW7_1
0.3056
p.G426R
TCGA-81-5911
GBM
TCGA
PPLTPVLT
DEG_SCF_FBW7_1
0.1111
p.G426R
DO13546
GBM
ICGC
PPLTPVLT
DEG_SCF_FBW7_1
0.1111
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Drug responses associated with SIGLEC1 mutations
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Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
No data available in table
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All proteins holding degron of PPLTPVLT
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9BZZ2
Sialoadhesin
DEG_SCF_FBW7_1
411:418
PPLTPVLT
FBXW7
0.6204
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