DegronMD

Uniprot ID: Q9BZZ2

Source protein: Sialoadhesin

Source gene: SIGLEC1

Class: DEG_SCF_FBW7_1

Location: 411:418

E3 ligase: FBXW7

DEGRON score: 0.6204

ASA_SCORE: 79.75

COIL: 0.8066

CONS_SCORE: 0.6873

DSS_SCORE: 0.1155

HELIX: 0.0153

FCONS_SCORE: 0.9617

RIG_SCORE: 0.8353

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G426R	TCGA-81-5911	GBM	TCGA	PPLTPVLT	DEG_SCF_FBW7_1	0.1111
p.G426R	DO13546	GBM	ICGC	PPLTPVLT	DEG_SCF_FBW7_1	0.1111
p.P415S	TCGA-D3-A3C3	SKCM	TCGA	PPLTPVLT	DEG_SCF_FBW7_1	0.6752
p.P415S	DO47667	SKCM	ICGC	PPLTPVLT	DEG_SCF_FBW7_1	0.6752
p.A419T	TCGA-FI-A2D5	UCEC	TCGA	PPLTPVLT	DEG_SCF_FBW7_1	0.3056
p.A419T	DO41331	UCEC	ICGC	PPLTPVLT	DEG_SCF_FBW7_1	0.3056
p.P412S	TCGA-XK-AAIW	PRAD	TCGA	PPLTPVLT	DEG_SCF_FBW7_1	0.5641
p.P412S	DO51407	PRAD	ICGC	PPLTPVLT	DEG_SCF_FBW7_1	0.5641
p.P411L	DO234222	ESAD	ICGC	PPLTPVLT	DEG_SCF_FBW7_1	0.6471
p.A419P	DO228986	LICA	ICGC	PPLTPVLT	DEG_SCF_FBW7_1	0.3056
p.L417M	DO229041	LICA	ICGC	PPLTPVLT	DEG_SCF_FBW7_1	0.5999
p.V416F	DO232761	PBCA	ICGC	PPLTPVLT	DEG_SCF_FBW7_1	0.5957

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BZZ2	Sialoadhesin	DEG_SCF_FBW7_1	411:418	PPLTPVLT	FBXW7	0.6204	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons