DegronMD - Q8IU81(IRF2BP1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P408L	TCGA-BF-A5EO	SKCM	TCGA	SAETPGVPSP	DEG_COP1_1	413:422	Mutation rewiring degron network	0.1944
p.P408L	DO219450	SKCM	ICGC	SAETPGVPSP	DEG_COP1_1	413:422	Mutation rewiring degron network	0.1944
p.A424V	TCGA-CV-7568	HNSC	TCGA	SAETPGVPSP	DEG_COP1_1	413:422	Mutation rewiring degron network	0.2778
p.A424V	DO14160	HNSC	ICGC	SAETPGVPSP	DEG_COP1_1	413:422	Mutation rewiring degron network	0.2778
p.A424V	DO229204	THCA	ICGC	SAETPGVPSP	DEG_COP1_1	413:422	Mutation rewiring degron network	0.2778
p.A424V	SIDM00373	Endometrial Carcinoma	GDSC	SAETPGVPSP	DEG_COP1_1	413:422	Mutation rewiring degron network	0.2778
p.A424V	ACH-000974	Endometrial/Uterine Cancer	CCLE	SAETPGVPSP	DEG_COP1_1	413:422	Mutation rewiring degron network	0.2778
p.A424V	ACH-002026	Endometrial/Uterine Cancer	CCLE	SAETPGVPSP	DEG_COP1_1	413:422	Mutation rewiring degron network	0.2778
p.A424V	SNG-M	endometrium	COSMIC	SAETPGVPSP	DEG_COP1_1	413:422	Mutation rewiring degron network	0.2778
p.P417L	TCGA-EB-A41A	SKCM	TCGA	SAETPGVPSP	DEG_COP1_1	413:422	Mutation altering degron motif	0.6471
p.P417L	DO37429	SKCM	ICGC	SAETPGVPSP	DEG_COP1_1	413:422	Mutation altering degron motif	0.6471
p.S413F	TCGA-EE-A2MT	SKCM	TCGA	SAETPGVPSP	DEG_COP1_1	413:422	Mutation altering degron motif	0.9093
p.S413F	DO38051	SKCM	ICGC	SAETPGVPSP	DEG_COP1_1	413:422	Mutation altering degron motif	0.9093
p.A430V	TCGA-EY-A1GU	UCEC	TCGA	SAETPGVPSP	DEG_COP1_1	413:422	Mutation rewiring degron network	0.1111
p.A430V	DO41518	UCEC	ICGC	SAETPGVPSP	DEG_COP1_1	413:422	Mutation rewiring degron network	0.1111
p.G409S	TCGA-GC-A3WC	BLCA	TCGA	SAETPGVPSP	DEG_COP1_1	413:422	Mutation rewiring degron network	0.2222
p.G409S	DO755	BLCA	ICGC	SAETPGVPSP	DEG_COP1_1	413:422	Mutation rewiring degron network	0.2222
p.A414G	DO228483	BRCA	ICGC	SAETPGVPSP	DEG_COP1_1	413:422	Mutation altering degron motif	0.6429
p.A414G	DO229005	COCA	ICGC	SAETPGVPSP	DEG_COP1_1	413:422	Mutation altering degron motif	0.6429
p.A414G	DO229505	LAML	ICGC	SAETPGVPSP	DEG_COP1_1	413:422	Mutation altering degron motif	0.6429
p.A414G	SIDM00425	Ovarian Carcinoma	GDSC	SAETPGVPSP	DEG_COP1_1	413:422	Mutation altering degron motif	0.6429
p.A414G	SIDM00331	B-Lymphoblastic Leukemia	GDSC	SAETPGVPSP	DEG_COP1_1	413:422	Mutation altering degron motif	0.6429
p.A414G	SIDM00373	Endometrial Carcinoma	GDSC	SAETPGVPSP	DEG_COP1_1	413:422	Mutation altering degron motif	0.6429
p.A414G	SIDM00234	Other Solid Cancers	GDSC	SAETPGVPSP	DEG_COP1_1	413:422	Mutation altering degron motif	0.6429
p.A414G	SIDM00577	Neuroblastoma	GDSC	SAETPGVPSP	DEG_COP1_1	413:422	Mutation altering degron motif	0.6429
p.A414G	SIDM00584	Osteosarcoma	GDSC	SAETPGVPSP	DEG_COP1_1	413:422	Mutation altering degron motif	0.6429
p.A414G	SIDM00547	Non-Small Cell Lung Carcinoma	GDSC	SAETPGVPSP	DEG_COP1_1	413:422	Mutation altering degron motif	0.6429
p.A414G	SIDM00087	Plasma Cell Myeloma	GDSC	SAETPGVPSP	DEG_COP1_1	413:422	Mutation altering degron motif	0.6429
p.A414G	SIDM00607	Glioblastoma	GDSC	SAETPGVPSP	DEG_COP1_1	413:422	Mutation altering degron motif	0.6429
p.A414G	SIDM01259	B-Lymphoblastic Leukemia	GDSC	SAETPGVPSP	DEG_COP1_1	413:422	Mutation altering degron motif	0.6429
p.A414G	SIDM01144	Gastric Carcinoma	GDSC	SAETPGVPSP	DEG_COP1_1	413:422	Mutation altering degron motif	0.6429
p.A414G	SIDM01028	Esophageal Squamous Cell Carcinoma	GDSC	SAETPGVPSP	DEG_COP1_1	413:422	Mutation altering degron motif	0.6429
p.A414G	SIDM00573	Glioblastoma	GDSC	SAETPGVPSP	DEG_COP1_1	413:422	Mutation altering degron motif	0.6429
p.A414G	SIDM00552	Rhabdomyosarcoma	GDSC	SAETPGVPSP	DEG_COP1_1	413:422	Mutation altering degron motif	0.6429
p.A414G	SIDM00771	Non-Small Cell Lung Carcinoma	GDSC	SAETPGVPSP	DEG_COP1_1	413:422	Mutation altering degron motif	0.6429
p.A414G	SIDM00337	Melanoma	GDSC	SAETPGVPSP	DEG_COP1_1	413:422	Mutation altering degron motif	0.6429
p.A414G	SIDM00354	Squamous Cell Lung Carcinoma	GDSC	SAETPGVPSP	DEG_COP1_1	413:422	Mutation altering degron motif	0.6429
p.A414G	SIDM01181	Hepatocellular Carcinoma	GDSC	SAETPGVPSP	DEG_COP1_1	413:422	Mutation altering degron motif	0.6429
p.A414G	SIDM01196	Hepatocellular Carcinoma	GDSC	SAETPGVPSP	DEG_COP1_1	413:422	Mutation altering degron motif	0.6429
p.A414G	SIDM00054	Pancreatic Carcinoma	GDSC	SAETPGVPSP	DEG_COP1_1	413:422	Mutation altering degron motif	0.6429
p.A414G	SIDM00489	Oral Cavity Carcinoma	GDSC	SAETPGVPSP	DEG_COP1_1	413:422	Mutation altering degron motif	0.6429
p.A414G	SIDM00294	Small Cell Lung Carcinoma	GDSC	SAETPGVPSP	DEG_COP1_1	413:422	Mutation altering degron motif	0.6429
p.A414G	SIDM00564	Ovarian Carcinoma	GDSC	SAETPGVPSP	DEG_COP1_1	413:422	Mutation altering degron motif	0.6429
p.A414G	SIDM00237	Non-Small Cell Lung Carcinoma	GDSC	SAETPGVPSP	DEG_COP1_1	413:422	Mutation altering degron motif	0.6429
p.A414G	SIDM00339	Non-Small Cell Lung Carcinoma	GDSC	SAETPGVPSP	DEG_COP1_1	413:422	Mutation altering degron motif	0.6429
p.A414G	SIDM01653	Non-Cancerous	GDSC	SAETPGVPSP	DEG_COP1_1	413:422	Mutation altering degron motif	0.6429
p.A414G	SIDM00207	Glioblastoma	GDSC	SAETPGVPSP	DEG_COP1_1	413:422	Mutation altering degron motif	0.6429
p.A414G	SIDM00882	Breast Carcinoma	GDSC	SAETPGVPSP	DEG_COP1_1	413:422	Mutation altering degron motif	0.6429
p.A414G	SIDM00807	Bladder Carcinoma	GDSC	SAETPGVPSP	DEG_COP1_1	413:422	Mutation altering degron motif	0.6429
p.A414G	SIDM01061	Oral Cavity Carcinoma	GDSC	SAETPGVPSP	DEG_COP1_1	413:422	Mutation altering degron motif	0.6429
p.A414G	SIDM01187	Breast Carcinoma	GDSC	SAETPGVPSP	DEG_COP1_1	413:422	Mutation altering degron motif	0.6429
p.A414G	SIDM00560	Gastric Carcinoma	GDSC	SAETPGVPSP	DEG_COP1_1	413:422	Mutation altering degron motif	0.6429
p.A414G	SIDM01257	Hepatocellular Carcinoma	GDSC	SAETPGVPSP	DEG_COP1_1	413:422	Mutation altering degron motif	0.6429
p.A414G	SIDM00326	Esophageal Squamous Cell Carcinoma	GDSC	SAETPGVPSP	DEG_COP1_1	413:422	Mutation altering degron motif	0.6429
p.A414G	SIDM00864	Cervical Carcinoma	GDSC	SAETPGVPSP	DEG_COP1_1	413:422	Mutation altering degron motif	0.6429
p.A414G	SIDM00996	Thyroid Gland Carcinoma	GDSC	SAETPGVPSP	DEG_COP1_1	413:422	Mutation altering degron motif	0.6429
p.A414G	SIDM00721	Small Cell Lung Carcinoma	GDSC	SAETPGVPSP	DEG_COP1_1	413:422	Mutation altering degron motif	0.6429
p.A414G	SIDM00982	Glioblastoma	GDSC	SAETPGVPSP	DEG_COP1_1	413:422	Mutation altering degron motif	0.6429
p.A414G	SIDM01140	Ovarian Carcinoma	GDSC	SAETPGVPSP	DEG_COP1_1	413:422	Mutation altering degron motif	0.6429
p.A414G	SIDM01033	Bladder Carcinoma	GDSC	SAETPGVPSP	DEG_COP1_1	413:422	Mutation altering degron motif	0.6429
p.A414G	SIDM01727	Chronic Myelogenous Leukemia	GDSC	SAETPGVPSP	DEG_COP1_1	413:422	Mutation altering degron motif	0.6429
p.A414G	SIDM01609	Endometrial Carcinoma	GDSC	SAETPGVPSP	DEG_COP1_1	413:422	Mutation altering degron motif	0.6429
p.A414G	SIDM01569	Hepatocellular Carcinoma	GDSC	SAETPGVPSP	DEG_COP1_1	413:422	Mutation altering degron motif	0.6429
p.A414G	SIDM00165	Other Solid Cancers	GDSC	SAETPGVPSP	DEG_COP1_1	413:422	Mutation altering degron motif	0.6429
p.A414G	SIDM00168	Head and Neck Carcinoma	GDSC	SAETPGVPSP	DEG_COP1_1	413:422	Mutation altering degron motif	0.6429
p.A414G	SIDM00062	Hepatocellular Carcinoma	GDSC	SAETPGVPSP	DEG_COP1_1	413:422	Mutation altering degron motif	0.6429
p.A414G	SIDM00158	Glioblastoma	GDSC	SAETPGVPSP	DEG_COP1_1	413:422	Mutation altering degron motif	0.6429
p.A414G	SIDM00163	Biliary Tract Carcinoma	GDSC	SAETPGVPSP	DEG_COP1_1	413:422	Mutation altering degron motif	0.6429
p.A414G	SIDM01445	Gastric Carcinoma	GDSC	SAETPGVPSP	DEG_COP1_1	413:422	Mutation altering degron motif	0.6429
p.A414G	SIDM01690	Plasma Cell Myeloma	GDSC	SAETPGVPSP	DEG_COP1_1	413:422	Mutation altering degron motif	0.6429
p.A414G	SIDM01559	Melanoma	GDSC	SAETPGVPSP	DEG_COP1_1	413:422	Mutation altering degron motif	0.6429
p.A414G	SIDM01490	Small Cell Lung Carcinoma	GDSC	SAETPGVPSP	DEG_COP1_1	413:422	Mutation altering degron motif	0.6429
p.A414G	SIDM01574	Plasma Cell Myeloma	GDSC	SAETPGVPSP	DEG_COP1_1	413:422	Mutation altering degron motif	0.6429
p.E431Q	DO229351	LAML	ICGC	SAETPGVPSP	DEG_COP1_1	413:422	Mutation rewiring degron network	0.0833
p.P411Q	DO229034	LICA	ICGC	SAETPGVPSP	DEG_COP1_1	413:422	Mutation rewiring degron network	0.2778
p.E415K	DO222390	MELA	ICGC	SAETPGVPSP	DEG_COP1_1	413:422	Mutation altering degron motif	0.591
p.A407V	SIDM00661	B-Cell Non-Hodgkin's Lymphoma	GDSC	SAETPGVPSP	DEG_COP1_1	413:422	Mutation rewiring degron network	0.1667
p.A407V	ACH-000914	Lymphoma	CCLE	SAETPGVPSP	DEG_COP1_1	413:422	Mutation rewiring degron network	0.1667
p.A407V	HT	haematopoietic and lymphoid tissue	COSMIC	SAETPGVPSP	DEG_COP1_1	413:422	Mutation rewiring degron network	0.1667
p.T416S	SIDM00267	Biliary Tract Carcinoma	GDSC	SAETPGVPSP	DEG_COP1_1	413:422	Mutation altering degron motif	0.7116
p.T416S	ACH-002312	Gallbladder Cancer	CCLE	SAETPGVPSP	DEG_COP1_1	413:422	Mutation altering degron motif	0.7116
p.T416S	TGBC24TKB	biliary tract	COSMIC	SAETPGVPSP	DEG_COP1_1	413:422	Mutation altering degron motif	0.7116
p.Q465K	ACH-000923	Lymphoma	CCLE	AASST	DEG_SPOP_SBC_1	455:459	Mutation rewiring degron network	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

IRF2BP1

UniProt ID: Q8IU81

Entrez ID: 26145

Protein name: Interferon regulatory factor 2-binding protein 1 (IRF-2-binding protein 1) (IRF-2BP1) (Probable E3 ubiquitin-protein ligase IRF2BP1) (EC 2.3.2.27) (Probable RING-type E3 ubiquitin transferase IRF2BP1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for IRF2BP1 in