DegronMD

Uniprot ID: Q8IU81

Source protein: Interferon regulatory factor 2-binding protein 1

Source gene: IRF2BP1

Class: DEG_COP1_1

Location: 413:422

E3 ligase: COP1

DEGRON score: 0.9986

ASA_SCORE: 75.12

COIL: 0.9043

CONS_SCORE: 0.3516

DSS_SCORE: 0.5592

HELIX: 0.0528

FCONS_SCORE: 1.0776

RIG_SCORE: 0.651

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P408L	TCGA-BF-A5EO	SKCM	TCGA	SAETPGVPSP	DEG_COP1_1	0.1944
p.P408L	DO219450	SKCM	ICGC	SAETPGVPSP	DEG_COP1_1	0.1944
p.A424V	TCGA-CV-7568	HNSC	TCGA	SAETPGVPSP	DEG_COP1_1	0.2778
p.A424V	DO14160	HNSC	ICGC	SAETPGVPSP	DEG_COP1_1	0.2778
p.A424V	DO229204	THCA	ICGC	SAETPGVPSP	DEG_COP1_1	0.2778
p.A424V	SIDM00373	Endometrial Carcinoma	GDSC	SAETPGVPSP	DEG_COP1_1	0.2778
p.A424V	ACH-000974	Endometrial/Uterine Cancer	CCLE	SAETPGVPSP	DEG_COP1_1	0.2778
p.A424V	ACH-002026	Endometrial/Uterine Cancer	CCLE	SAETPGVPSP	DEG_COP1_1	0.2778
p.A424V	SNG-M	endometrium	COSMIC	SAETPGVPSP	DEG_COP1_1	0.2778
p.P417L	TCGA-EB-A41A	SKCM	TCGA	SAETPGVPSP	DEG_COP1_1	0.6471
p.P417L	DO37429	SKCM	ICGC	SAETPGVPSP	DEG_COP1_1	0.6471
p.S413F	TCGA-EE-A2MT	SKCM	TCGA	SAETPGVPSP	DEG_COP1_1	0.9093
p.S413F	DO38051	SKCM	ICGC	SAETPGVPSP	DEG_COP1_1	0.9093
p.A430V	TCGA-EY-A1GU	UCEC	TCGA	SAETPGVPSP	DEG_COP1_1	0.1111
p.A430V	DO41518	UCEC	ICGC	SAETPGVPSP	DEG_COP1_1	0.1111
p.G409S	TCGA-GC-A3WC	BLCA	TCGA	SAETPGVPSP	DEG_COP1_1	0.2222
p.G409S	DO755	BLCA	ICGC	SAETPGVPSP	DEG_COP1_1	0.2222
p.A414G	DO228483	BRCA	ICGC	SAETPGVPSP	DEG_COP1_1	0.6429
p.A414G	DO229005	COCA	ICGC	SAETPGVPSP	DEG_COP1_1	0.6429
p.A414G	DO229505	LAML	ICGC	SAETPGVPSP	DEG_COP1_1	0.6429
p.A414G	SIDM00425	Ovarian Carcinoma	GDSC	SAETPGVPSP	DEG_COP1_1	0.6429
p.A414G	SIDM00331	B-Lymphoblastic Leukemia	GDSC	SAETPGVPSP	DEG_COP1_1	0.6429
p.A414G	SIDM00373	Endometrial Carcinoma	GDSC	SAETPGVPSP	DEG_COP1_1	0.6429
p.A414G	SIDM00234	Other Solid Cancers	GDSC	SAETPGVPSP	DEG_COP1_1	0.6429
p.A414G	SIDM00577	Neuroblastoma	GDSC	SAETPGVPSP	DEG_COP1_1	0.6429
p.A414G	SIDM00584	Osteosarcoma	GDSC	SAETPGVPSP	DEG_COP1_1	0.6429
p.A414G	SIDM00547	Non-Small Cell Lung Carcinoma	GDSC	SAETPGVPSP	DEG_COP1_1	0.6429
p.A414G	SIDM00087	Plasma Cell Myeloma	GDSC	SAETPGVPSP	DEG_COP1_1	0.6429
p.A414G	SIDM00607	Glioblastoma	GDSC	SAETPGVPSP	DEG_COP1_1	0.6429
p.A414G	SIDM01259	B-Lymphoblastic Leukemia	GDSC	SAETPGVPSP	DEG_COP1_1	0.6429
p.A414G	SIDM01144	Gastric Carcinoma	GDSC	SAETPGVPSP	DEG_COP1_1	0.6429
p.A414G	SIDM01028	Esophageal Squamous Cell Carcinoma	GDSC	SAETPGVPSP	DEG_COP1_1	0.6429
p.A414G	SIDM00573	Glioblastoma	GDSC	SAETPGVPSP	DEG_COP1_1	0.6429
p.A414G	SIDM00552	Rhabdomyosarcoma	GDSC	SAETPGVPSP	DEG_COP1_1	0.6429
p.A414G	SIDM00771	Non-Small Cell Lung Carcinoma	GDSC	SAETPGVPSP	DEG_COP1_1	0.6429
p.A414G	SIDM00337	Melanoma	GDSC	SAETPGVPSP	DEG_COP1_1	0.6429
p.A414G	SIDM00354	Squamous Cell Lung Carcinoma	GDSC	SAETPGVPSP	DEG_COP1_1	0.6429
p.A414G	SIDM01181	Hepatocellular Carcinoma	GDSC	SAETPGVPSP	DEG_COP1_1	0.6429
p.A414G	SIDM01196	Hepatocellular Carcinoma	GDSC	SAETPGVPSP	DEG_COP1_1	0.6429
p.A414G	SIDM00054	Pancreatic Carcinoma	GDSC	SAETPGVPSP	DEG_COP1_1	0.6429
p.A414G	SIDM00489	Oral Cavity Carcinoma	GDSC	SAETPGVPSP	DEG_COP1_1	0.6429
p.A414G	SIDM00294	Small Cell Lung Carcinoma	GDSC	SAETPGVPSP	DEG_COP1_1	0.6429
p.A414G	SIDM00564	Ovarian Carcinoma	GDSC	SAETPGVPSP	DEG_COP1_1	0.6429
p.A414G	SIDM00237	Non-Small Cell Lung Carcinoma	GDSC	SAETPGVPSP	DEG_COP1_1	0.6429
p.A414G	SIDM00339	Non-Small Cell Lung Carcinoma	GDSC	SAETPGVPSP	DEG_COP1_1	0.6429
p.A414G	SIDM01653	Non-Cancerous	GDSC	SAETPGVPSP	DEG_COP1_1	0.6429
p.A414G	SIDM00207	Glioblastoma	GDSC	SAETPGVPSP	DEG_COP1_1	0.6429
p.A414G	SIDM00882	Breast Carcinoma	GDSC	SAETPGVPSP	DEG_COP1_1	0.6429
p.A414G	SIDM00807	Bladder Carcinoma	GDSC	SAETPGVPSP	DEG_COP1_1	0.6429
p.A414G	SIDM01061	Oral Cavity Carcinoma	GDSC	SAETPGVPSP	DEG_COP1_1	0.6429
p.A414G	SIDM01187	Breast Carcinoma	GDSC	SAETPGVPSP	DEG_COP1_1	0.6429
p.A414G	SIDM00560	Gastric Carcinoma	GDSC	SAETPGVPSP	DEG_COP1_1	0.6429
p.A414G	SIDM01257	Hepatocellular Carcinoma	GDSC	SAETPGVPSP	DEG_COP1_1	0.6429
p.A414G	SIDM00326	Esophageal Squamous Cell Carcinoma	GDSC	SAETPGVPSP	DEG_COP1_1	0.6429
p.A414G	SIDM00864	Cervical Carcinoma	GDSC	SAETPGVPSP	DEG_COP1_1	0.6429
p.A414G	SIDM00996	Thyroid Gland Carcinoma	GDSC	SAETPGVPSP	DEG_COP1_1	0.6429
p.A414G	SIDM00721	Small Cell Lung Carcinoma	GDSC	SAETPGVPSP	DEG_COP1_1	0.6429
p.A414G	SIDM00982	Glioblastoma	GDSC	SAETPGVPSP	DEG_COP1_1	0.6429
p.A414G	SIDM01140	Ovarian Carcinoma	GDSC	SAETPGVPSP	DEG_COP1_1	0.6429
p.A414G	SIDM01033	Bladder Carcinoma	GDSC	SAETPGVPSP	DEG_COP1_1	0.6429
p.A414G	SIDM01727	Chronic Myelogenous Leukemia	GDSC	SAETPGVPSP	DEG_COP1_1	0.6429
p.A414G	SIDM01609	Endometrial Carcinoma	GDSC	SAETPGVPSP	DEG_COP1_1	0.6429
p.A414G	SIDM01569	Hepatocellular Carcinoma	GDSC	SAETPGVPSP	DEG_COP1_1	0.6429
p.A414G	SIDM00165	Other Solid Cancers	GDSC	SAETPGVPSP	DEG_COP1_1	0.6429
p.A414G	SIDM00168	Head and Neck Carcinoma	GDSC	SAETPGVPSP	DEG_COP1_1	0.6429
p.A414G	SIDM00062	Hepatocellular Carcinoma	GDSC	SAETPGVPSP	DEG_COP1_1	0.6429
p.A414G	SIDM00158	Glioblastoma	GDSC	SAETPGVPSP	DEG_COP1_1	0.6429
p.A414G	SIDM00163	Biliary Tract Carcinoma	GDSC	SAETPGVPSP	DEG_COP1_1	0.6429
p.A414G	SIDM01445	Gastric Carcinoma	GDSC	SAETPGVPSP	DEG_COP1_1	0.6429
p.A414G	SIDM01690	Plasma Cell Myeloma	GDSC	SAETPGVPSP	DEG_COP1_1	0.6429
p.A414G	SIDM01559	Melanoma	GDSC	SAETPGVPSP	DEG_COP1_1	0.6429
p.A414G	SIDM01490	Small Cell Lung Carcinoma	GDSC	SAETPGVPSP	DEG_COP1_1	0.6429
p.A414G	SIDM01574	Plasma Cell Myeloma	GDSC	SAETPGVPSP	DEG_COP1_1	0.6429
p.E431Q	DO229351	LAML	ICGC	SAETPGVPSP	DEG_COP1_1	0.0833
p.P411Q	DO229034	LICA	ICGC	SAETPGVPSP	DEG_COP1_1	0.2778
p.E415K	DO222390	MELA	ICGC	SAETPGVPSP	DEG_COP1_1	0.591
p.A407V	SIDM00661	B-Cell Non-Hodgkin's Lymphoma	GDSC	SAETPGVPSP	DEG_COP1_1	0.1667
p.A407V	ACH-000914	Lymphoma	CCLE	SAETPGVPSP	DEG_COP1_1	0.1667
p.A407V	HT	haematopoietic_and_lymphoid_tissue	COSMIC	SAETPGVPSP	DEG_COP1_1	0.1667
p.T416S	SIDM00267	Biliary Tract Carcinoma	GDSC	SAETPGVPSP	DEG_COP1_1	0.7116
p.T416S	ACH-002312	Gallbladder Cancer	CCLE	SAETPGVPSP	DEG_COP1_1	0.7116
p.T416S	TGBC24TKB	biliary_tract	COSMIC	SAETPGVPSP	DEG_COP1_1	0.7116

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SAETPGVPSP

Degron related mutations and impact score

Drug responses associated with IRF2BP1 mutations

All proteins holding degron of SAETPGVPSP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IU81	Interferon regulatory factor 2-binding protein 1	DEG_COP1_1	413:422	SAETPGVPSP	COP1	0.9986	More...