DegronMD

Uniprot ID: Q86TM6

Source protein: E3 ubiquitin-protein ligase synoviolin

Source gene: SYVN1

Class: DEG_SCF_FBW7_1

Location: 567:572

E3 ligase: FBXW7

DEGRON score: 0.9928

ASA_SCORE: 83.5333

COIL: 0.9693

CONS_SCORE: 0.2125

DSS_SCORE: 0.8266

HELIX: 0.0107

FCONS_SCORE: 0.9742

RIG_SCORE: 0.5002

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M578I	TCGA-L5-A4OE	ESCA	TCGA	PTPGAS	DEG_SCF_FBW7_1	0.1667
p.S561R	TCGA-OR-A5LC	ACC	TCGA	PTPGAS	DEG_SCF_FBW7_1	0.1667
p.S561R	DO229027	LICA	ICGC	PTPGAS	DEG_SCF_FBW7_1	0.1667
p.P567R	DO233876	GACA	ICGC	PTPGAS	DEG_SCF_FBW7_1	0.7512
p.P562H	DU-145	prostate	COSMIC	PTPGAS	DEG_SCF_FBW7_1	0.6389
p.L559P	CCK-81	large_intestine	COSMIC	PTPGAS	DEG_SCF_FBW7_1	0.1111
p.A564T	COLO-824	breast	COSMIC	PTPGAS	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75533	Splicing factor 3B subunit 1	DEG_SCF_FBW7_1	327:332	PTPGAS	FBXW7	0.9834	More...
Q86TM6	E3 ubiquitin-protein ligase synoviolin	DEG_SCF_FBW7_1	567:572	PTPGAS	FBXW7	0.9928	More...
Q8NAG6	Ankyrin repeat and LEM domain-containing protein 1	DEG_SCF_FBW7_1	310:315	PTPGAS	FBXW7	0.9884	More...
Q5VZ18	SH2 domain-containing adapter protein E	DEG_SCF_FBW7_1	5:10	PTPGAS	FBXW7	0.9762	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons