DegronMD - Q8NAG6(ANKLE1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A257V	TCGA-AP-A051	UCEC	TCGA	TRQGLLHVV	DEG_APCC_DBOX_1	247:255	Mutation rewiring degron network	0.2778
p.A257V	DO42673	UCEC	ICGC	TRQGLLHVV	DEG_APCC_DBOX_1	247:255	Mutation rewiring degron network	0.2778
p.R300M	TCGA-AP-A059	UCEC	TCGA	PTPGAS	DEG_SCF_FBW7_1	310:315	Mutation rewiring degron network	0.0556
p.R300M	DO41361	UCEC	ICGC	PTPGAS	DEG_SCF_FBW7_1	310:315	Mutation rewiring degron network	0.0556
p.A241T	TCGA-AX-A0J1	UCEC	TCGA	TRQGLLHVV	DEG_APCC_DBOX_1	247:255	Mutation rewiring degron network	0.1667
p.A241T	DO41199	UCEC	ICGC	TRQGLLHVV	DEG_APCC_DBOX_1	247:255	Mutation rewiring degron network	0.1667
p.V261L	TCGA-D7-A747	STAD	TCGA	TRQGLLHVV	DEG_APCC_DBOX_1	247:255	Mutation rewiring degron network	0.1667
p.V261L	DO51735	STAD	ICGC	TRQGLLHVV	DEG_APCC_DBOX_1	247:255	Mutation rewiring degron network	0.1667
p.P238L	TCGA-FR-A3YO	SKCM	TCGA	TRQGLLHVV	DEG_APCC_DBOX_1	247:255	Mutation rewiring degron network	0.0833
p.P238L	DO37419	SKCM	ICGC	TRQGLLHVV	DEG_APCC_DBOX_1	247:255	Mutation rewiring degron network	0.0833
p.P238A	TCGA-GU-AATQ	BLCA	TCGA	TRQGLLHVV	DEG_APCC_DBOX_1	247:255	Mutation rewiring degron network	0.0833
p.P238A	DO51896	BLCA	ICGC	TRQGLLHVV	DEG_APCC_DBOX_1	247:255	Mutation rewiring degron network	0.0833
p.P306A	TCGA-UD-AAC5	MESO	TCGA	PTPGAS	DEG_SCF_FBW7_1	310:315	Mutation rewiring degron network	0.2222
p.P312S	TCGA-WE-A8K5	SKCM	TCGA	PTPGAS	DEG_SCF_FBW7_1	310:315	Mutation altering degron motif	0.6752
p.P312S	DO51282	SKCM	ICGC	PTPGAS	DEG_SCF_FBW7_1	310:315	Mutation altering degron motif	0.6752
p.S315F	TCGA-XF-A9SI	BLCA	TCGA	PTPGAS	DEG_SCF_FBW7_1	310:315	Mutation altering degron motif	0.7982
p.S315F	DO51914	BLCA	ICGC	PTPGAS	DEG_SCF_FBW7_1	310:315	Mutation altering degron motif	0.7982
p.T311P	DO229010	COCA	ICGC	PTPGAS	DEG_SCF_FBW7_1	310:315	Mutation altering degron motif	0.7031
p.T311P	DO229013	COCA	ICGC	PTPGAS	DEG_SCF_FBW7_1	310:315	Mutation altering degron motif	0.7031
p.T311P	DO229003	COCA	ICGC	PTPGAS	DEG_SCF_FBW7_1	310:315	Mutation altering degron motif	0.7031
p.T311P	DO231114	LUSC	ICGC	PTPGAS	DEG_SCF_FBW7_1	310:315	Mutation altering degron motif	0.7031
p.G250E	DO233240	GACA	ICGC	TRQGLLHVV	DEG_APCC_DBOX_1	247:255	Mutation altering degron motif	0.6087
p.G313E	DO220894	MELA	ICGC	PTPGAS	DEG_SCF_FBW7_1	310:315	Mutation altering degron motif	0.6087
p.G313R	DO220894	MELA	ICGC	PTPGAS	DEG_SCF_FBW7_1	310:315	Mutation altering degron motif	0.6457
p.L305F	SIDM01123	Prostate Carcinoma	GDSC	PTPGAS	DEG_SCF_FBW7_1	310:315	Mutation rewiring degron network	0.1944
p.L305F	NCI-H660	prostate	COSMIC	PTPGAS	DEG_SCF_FBW7_1	310:315	Mutation rewiring degron network	0.1944
p.L164R	SIDM00845	Burkitt's Lymphoma	GDSC	PGTPGLS	DEG_SCF_FBW7_1	152:158	Mutation rewiring degron network	0.1667
p.L164R	Daudi	haematopoietic and lymphoid tissue	COSMIC	PGTPGLS	DEG_SCF_FBW7_1	152:158	Mutation rewiring degron network	0.1667
p.H310R	SIDM00386	Ewing's Sarcoma	GDSC	PTPGAS	DEG_SCF_FBW7_1	310:315	Mutation altering degron motif	0.8244
p.H310R	MHH-ES-1	bone	COSMIC	PTPGAS	DEG_SCF_FBW7_1	310:315	Mutation altering degron motif	0.8244
p.H310N	SIDM00238	Ovarian Carcinoma	GDSC	PTPGAS	DEG_SCF_FBW7_1	310:315	Mutation altering degron motif	0.7423
p.H310N	OVK-18	ovary	COSMIC	PTPGAS	DEG_SCF_FBW7_1	310:315	Mutation altering degron motif	0.7423
p.Q319R	SIDM00333	Endometrial Carcinoma	GDSC	PTPGAS	DEG_SCF_FBW7_1	310:315	Mutation rewiring degron network	0.2222
p.Q319R	MFE-319	endometrium	COSMIC	PTPGAS	DEG_SCF_FBW7_1	310:315	Mutation rewiring degron network	0.2222
p.T321M	SIDM00683	Prostate Carcinoma	GDSC	PTPGAS	DEG_SCF_FBW7_1	310:315	Mutation rewiring degron network	0.1667
p.T321M	LNCaP-Clone-FGC	prostate	COSMIC	PTPGAS	DEG_SCF_FBW7_1	310:315	Mutation rewiring degron network	0.1667
p.G243R	SIDM01188	Pancreatic Carcinoma	GDSC	TRQGLLHVV	DEG_APCC_DBOX_1	247:255	Mutation rewiring degron network	0.2222
p.G243R	SU8686	pancreas	COSMIC	TRQGLLHVV	DEG_APCC_DBOX_1	247:255	Mutation rewiring degron network	0.2222
p.E239K	SIDM00207	Glioblastoma	GDSC	TRQGLLHVV	DEG_APCC_DBOX_1	247:255	Mutation rewiring degron network	0.1111
p.E239K	D-542MG	central nervous system	COSMIC	TRQGLLHVV	DEG_APCC_DBOX_1	247:255	Mutation rewiring degron network	0.1111
p.L251F	ACH-000177	Prostate Cancer	CCLE	TRQGLLHVV	DEG_APCC_DBOX_1	247:255	Mutation altering degron motif	0.6981
p.H256R	ACH-000391	Bone Cancer	CCLE	TRQGLLHVV	DEG_APCC_DBOX_1	247:255	Mutation rewiring degron network	0.3056
p.P160L	ACH-000884	Skin Cancer	CCLE	PGTPGLS	DEG_SCF_FBW7_1	152:158	Mutation rewiring degron network	0.2778
p.P160L	ACH-002159	Skin Cancer	CCLE	PGTPGLS	DEG_SCF_FBW7_1	152:158	Mutation rewiring degron network	0.2778
p.H256N	ACH-000947	Ovarian Cancer	CCLE	TRQGLLHVV	DEG_APCC_DBOX_1	247:255	Mutation rewiring degron network	0.3056
p.D166E	ACH-000948	Gastric Cancer	CCLE	PGTPGLS	DEG_SCF_FBW7_1	152:158	Mutation rewiring degron network	0.1111
p.Q265R	ACH-000988	Endometrial/Uterine Cancer	CCLE	TRQGLLHVV	DEG_APCC_DBOX_1	247:255	Mutation rewiring degron network	0.0556
p.A303V	ACH-000991	Colon/Colorectal Cancer	CCLE	PTPGAS	DEG_SCF_FBW7_1	310:315	Mutation rewiring degron network	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ANKLE1

UniProt ID: Q8NAG6

Entrez ID: 126549

Protein name: Ankyrin repeat and LEM domain-containing protein 1 (EC 3.1.-.-) (Ankyrin repeat domain-containing protein 41) (LEM-domain containing protein 3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ANKLE1 in