DegronMD

Uniprot ID: Q8NAG6

Source protein: Ankyrin repeat and LEM domain-containing protein 1

Source gene: ANKLE1

Class: DEG_SCF_FBW7_1

Location: 152:158

E3 ligase: FBXW7

DEGRON score: 0.933

ASA_SCORE: 56.1571

COIL: 0.8733

CONS_SCORE: 0.3094

DSS_SCORE: 0.9021

HELIX: 0.0531

FCONS_SCORE: 0.9483

RIG_SCORE: 0.5263

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L164R	SIDM00845	Burkitt's Lymphoma	GDSC	PGTPGLS	DEG_SCF_FBW7_1	0.1667
p.L164R	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	PGTPGLS	DEG_SCF_FBW7_1	0.1667
p.P160L	ACH-000884	Skin Cancer	CCLE	PGTPGLS	DEG_SCF_FBW7_1	0.2778
p.P160L	ACH-002159	Skin Cancer	CCLE	PGTPGLS	DEG_SCF_FBW7_1	0.2778
p.D166E	ACH-000948	Gastric Cancer	CCLE	PGTPGLS	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NAG6	Ankyrin repeat and LEM domain-containing protein 1	DEG_SCF_FBW7_1	152:158	PGTPGLS	FBXW7	0.933	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons