DegronMD

Uniprot ID: Q8NAG6

Source protein: Ankyrin repeat and LEM domain-containing protein 1

Source gene: ANKLE1

Class: DEG_SCF_FBW7_1

Location: 310:315

E3 ligase: FBXW7

DEGRON score: 0.9884

ASA_SCORE: 65.2

COIL: 0.8982

CONS_SCORE: 0.3887

DSS_SCORE: 0.5626

HELIX: 0.0678

FCONS_SCORE: 1.2923

RIG_SCORE: 0.5586

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R300M	TCGA-AP-A059	UCEC	TCGA	PTPGAS	DEG_SCF_FBW7_1	0.0556
p.R300M	DO41361	UCEC	ICGC	PTPGAS	DEG_SCF_FBW7_1	0.0556
p.P306A	TCGA-UD-AAC5	MESO	TCGA	PTPGAS	DEG_SCF_FBW7_1	0.2222
p.P312S	TCGA-WE-A8K5	SKCM	TCGA	PTPGAS	DEG_SCF_FBW7_1	0.6752
p.P312S	DO51282	SKCM	ICGC	PTPGAS	DEG_SCF_FBW7_1	0.6752
p.S315F	TCGA-XF-A9SI	BLCA	TCGA	PTPGAS	DEG_SCF_FBW7_1	0.7982
p.S315F	DO51914	BLCA	ICGC	PTPGAS	DEG_SCF_FBW7_1	0.7982
p.T311P	DO229010	COCA	ICGC	PTPGAS	DEG_SCF_FBW7_1	0.7031
p.T311P	DO229013	COCA	ICGC	PTPGAS	DEG_SCF_FBW7_1	0.7031
p.T311P	DO229003	COCA	ICGC	PTPGAS	DEG_SCF_FBW7_1	0.7031
p.T311P	DO231114	LUSC	ICGC	PTPGAS	DEG_SCF_FBW7_1	0.7031
p.G313E	DO220894	MELA	ICGC	PTPGAS	DEG_SCF_FBW7_1	0.6087
p.G313R	DO220894	MELA	ICGC	PTPGAS	DEG_SCF_FBW7_1	0.6457
p.L305F	SIDM01123	Prostate Carcinoma	GDSC	PTPGAS	DEG_SCF_FBW7_1	0.1944
p.L305F	NCI-H660	prostate	COSMIC	PTPGAS	DEG_SCF_FBW7_1	0.1944
p.H310R	SIDM00386	Ewing's Sarcoma	GDSC	PTPGAS	DEG_SCF_FBW7_1	0.8244
p.H310R	MHH-ES-1	bone	COSMIC	PTPGAS	DEG_SCF_FBW7_1	0.8244
p.H310N	SIDM00238	Ovarian Carcinoma	GDSC	PTPGAS	DEG_SCF_FBW7_1	0.7423
p.H310N	OVK-18	ovary	COSMIC	PTPGAS	DEG_SCF_FBW7_1	0.7423
p.Q319R	SIDM00333	Endometrial Carcinoma	GDSC	PTPGAS	DEG_SCF_FBW7_1	0.2222
p.Q319R	MFE-319	endometrium	COSMIC	PTPGAS	DEG_SCF_FBW7_1	0.2222
p.T321M	SIDM00683	Prostate Carcinoma	GDSC	PTPGAS	DEG_SCF_FBW7_1	0.1667
p.T321M	LNCaP-Clone-FGC	prostate	COSMIC	PTPGAS	DEG_SCF_FBW7_1	0.1667
p.A303V	ACH-000991	Colon/Colorectal Cancer	CCLE	PTPGAS	DEG_SCF_FBW7_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75533	Splicing factor 3B subunit 1	DEG_SCF_FBW7_1	327:332	PTPGAS	FBXW7	0.9834	More...
Q86TM6	E3 ubiquitin-protein ligase synoviolin	DEG_SCF_FBW7_1	567:572	PTPGAS	FBXW7	0.9928	More...
Q8NAG6	Ankyrin repeat and LEM domain-containing protein 1	DEG_SCF_FBW7_1	310:315	PTPGAS	FBXW7	0.9884	More...
Q5VZ18	SH2 domain-containing adapter protein E	DEG_SCF_FBW7_1	5:10	PTPGAS	FBXW7	0.9762	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons