DegronMD

Uniprot ID: O75533

Source protein: Splicing factor 3B subunit 1

Source gene: SF3B1

Class: DEG_SCF_FBW7_1

Location: 327:332

E3 ligase: FBXW7

DEGRON score: 0.9834

ASA_SCORE: 70.1333

COIL: 0.9468

CONS_SCORE: 0.314

DSS_SCORE: 0.7577

HELIX: 0.02

FCONS_SCORE: 0.7459

RIG_SCORE: 0.605

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I323V	TCGA-56-7731	LUSC	TCGA	PTPGAS	DEG_SCF_FBW7_1	0.2222
p.I323V	DO45527	LUSC	ICGC	PTPGAS	DEG_SCF_FBW7_1	0.2222
p.P327L	TCGA-A5-A0G2	UCEC	TCGA	PTPGAS	DEG_SCF_FBW7_1	0.6471
p.P327L	DO41235	UCEC	ICGC	PTPGAS	DEG_SCF_FBW7_1	0.6471
p.P327L	ACH-001377	Pancreatic Cancer	CCLE	PTPGAS	DEG_SCF_FBW7_1	0.6471
p.R334I	TCGA-BS-A0UV	UCEC	TCGA	PTPGAS	DEG_SCF_FBW7_1	0.2778
p.R334I	DO42793	UCEC	ICGC	PTPGAS	DEG_SCF_FBW7_1	0.2778
p.D321V	TCGA-DD-AAE3	LIHC	TCGA	PTPGAS	DEG_SCF_FBW7_1	0.1667
p.D321V	DO52258	LIHC	ICGC	PTPGAS	DEG_SCF_FBW7_1	0.1667
p.P327R	TCGA-VQ-A91S	STAD	TCGA	PTPGAS	DEG_SCF_FBW7_1	0.7512
p.P327R	DO222352	STAD	ICGC	PTPGAS	DEG_SCF_FBW7_1	0.7512
p.A331D	DO229028	LICA	ICGC	PTPGAS	DEG_SCF_FBW7_1	0.6682
p.A331D	DO229045	LICA	ICGC	PTPGAS	DEG_SCF_FBW7_1	0.6682
p.P342T	DO229027	LICA	ICGC	PTPGAS	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75533	Splicing factor 3B subunit 1	DEG_SCF_FBW7_1	327:332	PTPGAS	FBXW7	0.9834	More...
Q86TM6	E3 ubiquitin-protein ligase synoviolin	DEG_SCF_FBW7_1	567:572	PTPGAS	FBXW7	0.9928	More...
Q8NAG6	Ankyrin repeat and LEM domain-containing protein 1	DEG_SCF_FBW7_1	310:315	PTPGAS	FBXW7	0.9884	More...
Q5VZ18	SH2 domain-containing adapter protein E	DEG_SCF_FBW7_1	5:10	PTPGAS	FBXW7	0.9762	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons