DegronMD - O75533(SF3B1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R124L	TCGA-49-AAR4	LUAD	TCGA	LDPFAD	LIG_APCC_ABBA_1	133:138	Mutation rewiring degron network	0.0833
p.R124L	DO218920	LUAD	ICGC	LDPFAD	LIG_APCC_ABBA_1	133:138	Mutation rewiring degron network	0.0833
p.I323V	TCGA-56-7731	LUSC	TCGA	PTPGAS	DEG_SCF_FBW7_1	327:332	Mutation rewiring degron network	0.2222
p.I323V	DO45527	LUSC	ICGC	PTPGAS	DEG_SCF_FBW7_1	327:332	Mutation rewiring degron network	0.2222
p.P351T	TCGA-66-2734	LUSC	TCGA	PVLTPGKT	DEG_SCF_FBW7_1	351:358	Mutation altering degron motif	0.7031
p.P351T	DO26430	LUSC	ICGC	PVLTPGKT	DEG_SCF_FBW7_1	351:358	Mutation altering degron motif	0.7031
p.P327L	TCGA-A5-A0G2	UCEC	TCGA	PTPGAS	DEG_SCF_FBW7_1	327:332	Mutation altering degron motif	0.6471
p.P327L	DO41235	UCEC	ICGC	PTPGAS	DEG_SCF_FBW7_1	327:332	Mutation altering degron motif	0.6471
p.P327L	ACH-001377	Pancreatic Cancer	CCLE	PTPGAS	DEG_SCF_FBW7_1	327:332	Mutation altering degron motif	0.6471
p.A368T	TCGA-AJ-A3EK	UCEC	TCGA	PVLTPGKT	DEG_SCF_FBW7_1	351:358	Mutation rewiring degron network	0.0556
p.A368T	DO41584	UCEC	ICGC	PVLTPGKT	DEG_SCF_FBW7_1	351:358	Mutation rewiring degron network	0.0556
p.A368T	SIDM02050	Colorectal Carcinoma	GDSC	PVLTPGKT	DEG_SCF_FBW7_1	351:358	Mutation rewiring degron network	0.0556
p.G139E	TCGA-AP-A1DK	UCEC	TCGA	LDPFAD	LIG_APCC_ABBA_1	133:138	Mutation rewiring degron network	0.3056
p.G139E	DO42033	UCEC	ICGC	LDPFAD	LIG_APCC_ABBA_1	133:138	Mutation rewiring degron network	0.3056
p.R124Q	TCGA-AX-A1CE	UCEC	TCGA	LDPFAD	LIG_APCC_ABBA_1	133:138	Mutation rewiring degron network	0.0833
p.R124Q	DO42280	UCEC	ICGC	LDPFAD	LIG_APCC_ABBA_1	133:138	Mutation rewiring degron network	0.0833
p.M147V	TCGA-AX-A2H8	UCEC	TCGA	LDPFAD	LIG_APCC_ABBA_1	133:138	Mutation rewiring degron network	0.0833
p.M147V	DO43674	UCEC	ICGC	LDPFAD	LIG_APCC_ABBA_1	133:138	Mutation rewiring degron network	0.0833
p.R334I	TCGA-BS-A0UV	UCEC	TCGA	PTPGAS	DEG_SCF_FBW7_1	327:332	Mutation rewiring degron network	0.2778
p.R334I	DO42793	UCEC	ICGC	PTPGAS	DEG_SCF_FBW7_1	327:332	Mutation rewiring degron network	0.2778
p.G140W	TCGA-CV-7252	HNSC	TCGA	LDPFAD	LIG_APCC_ABBA_1	133:138	Mutation rewiring degron network	0.2778
p.G140W	DO14176	HNSC	ICGC	LDPFAD	LIG_APCC_ABBA_1	133:138	Mutation rewiring degron network	0.2778
p.D321V	TCGA-DD-AAE3	LIHC	TCGA	PTPGAS	DEG_SCF_FBW7_1	327:332	Mutation rewiring degron network	0.1667
p.D321V	DO52258	LIHC	ICGC	PTPGAS	DEG_SCF_FBW7_1	327:332	Mutation rewiring degron network	0.1667
p.D255N	TCGA-DK-A3X1	BLCA	TCGA	PTPSHT	DEG_SCF_FBW7_1	256:261	Mutation rewiring degron network	0.3056
p.D255N	DO447	BLCA	ICGC	PTPSHT	DEG_SCF_FBW7_1	256:261	Mutation rewiring degron network	0.3056
p.P258L	TCGA-DM-A1HB	COAD	TCGA	PTPSHT	DEG_SCF_FBW7_1	256:261	Mutation altering degron motif	0.7582
p.T267N	TCGA-DW-7834	KIRP	TCGA	PTPSHT	DEG_SCF_FBW7_1	256:261	Mutation blocking phosphorylation signal	0.6111
p.T267N	DO20794	KIRP	ICGC	PTPSHT	DEG_SCF_FBW7_1	256:261	Mutation blocking phosphorylation signal	0.6111
p.P135S	TCGA-EE-A2MJ	SKCM	TCGA	LDPFAD	LIG_APCC_ABBA_1	133:138	Mutation altering degron motif	0.6752
p.P135S	DO38099	SKCM	ICGC	LDPFAD	LIG_APCC_ABBA_1	133:138	Mutation altering degron motif	0.6752
p.A368D	TCGA-VQ-A8P2	STAD	TCGA	PVLTPGKT	DEG_SCF_FBW7_1	351:358	Mutation rewiring degron network	0.0556
p.A368D	DO51761	STAD	ICGC	PVLTPGKT	DEG_SCF_FBW7_1	351:358	Mutation rewiring degron network	0.0556
p.P327R	TCGA-VQ-A91S	STAD	TCGA	PTPGAS	DEG_SCF_FBW7_1	327:332	Mutation altering degron motif	0.7512
p.P327R	DO222352	STAD	ICGC	PTPGAS	DEG_SCF_FBW7_1	327:332	Mutation altering degron motif	0.7512
p.P351L	TCGA-WE-A8K5	SKCM	TCGA	PVLTPGKT	DEG_SCF_FBW7_1	351:358	Mutation altering degron motif	0.6471
p.P351L	DO51282	SKCM	ICGC	PVLTPGKT	DEG_SCF_FBW7_1	351:358	Mutation altering degron motif	0.6471
p.P351S	TCGA-WE-A8K5	SKCM	TCGA	PVLTPGKT	DEG_SCF_FBW7_1	351:358	Mutation altering degron motif	0.6752
p.P351S	DO51282	SKCM	ICGC	PVLTPGKT	DEG_SCF_FBW7_1	351:358	Mutation altering degron motif	0.6752
p.I128F	DO227657	COCA	ICGC	LDPFAD	LIG_APCC_ABBA_1	133:138	Mutation rewiring degron network	0.1944
p.I127T	DO222762	COCA	ICGC	LDPFAD	LIG_APCC_ABBA_1	133:138	Mutation rewiring degron network	0.1667
p.A144T	DO229010	COCA	ICGC	LDPFAD	LIG_APCC_ABBA_1	133:138	Mutation rewiring degron network	0.1667
p.G347S	DO233882	GACA	ICGC	PVLTPGKT	DEG_SCF_FBW7_1	351:358	Mutation rewiring degron network	0.2222
p.T354N	DO228948	LICA	ICGC	PVLTPGKT	DEG_SCF_FBW7_1	351:358	Mutation altering degron motif	0.8166
p.A331D	DO229028	LICA	ICGC	PTPGAS	DEG_SCF_FBW7_1	327:332	Mutation altering degron motif	0.6682
p.A331D	DO229045	LICA	ICGC	PTPGAS	DEG_SCF_FBW7_1	327:332	Mutation altering degron motif	0.6682
p.A364D	DO229027	LICA	ICGC	PVLTPGKT	DEG_SCF_FBW7_1	351:358	Mutation rewiring degron network	0.1667
p.A364D	DO229026	LICA	ICGC	PVLTPGKT	DEG_SCF_FBW7_1	351:358	Mutation rewiring degron network	0.1667
p.P342T	DO229027	LICA	ICGC	PTPGAS	DEG_SCF_FBW7_1	327:332	Mutation rewiring degron network	0.0556
p.P342T	DO229027	LICA	ICGC	PVLTPGKT	DEG_SCF_FBW7_1	351:358	Mutation rewiring degron network	0.0833
p.A247E	DO229026	LICA	ICGC	PTPSHT	DEG_SCF_FBW7_1	256:261	Mutation rewiring degron network	0.0833
p.A247E	DO229032	LICA	ICGC	PTPSHT	DEG_SCF_FBW7_1	256:261	Mutation rewiring degron network	0.0833
p.T125N	DO229035	LICA	ICGC	LDPFAD	LIG_APCC_ABBA_1	133:138	Mutation blocking phosphorylation signal	0.5556
p.M126I	DO231026	LUSC	ICGC	LDPFAD	LIG_APCC_ABBA_1	133:138	Mutation rewiring degron network	0.1389
p.P262L	DO46329	OV	ICGC	PTPSHT	DEG_SCF_FBW7_1	256:261	Mutation rewiring degron network	0.3056
p.R132C	DO228138	PBCA	ICGC	LDPFAD	LIG_APCC_ABBA_1	133:138	Mutation rewiring degron network	0.3056
p.A263V	SIDM00481	Ovarian Carcinoma	GDSC	PTPSHT	DEG_SCF_FBW7_1	256:261	Mutation rewiring degron network	0.2778
p.A263V	OAW-28	ovary	COSMIC	PTPSHT	DEG_SCF_FBW7_1	256:261	Mutation rewiring degron network	0.2778

Kaplan plot for SF3B1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SF3B1

UniProt ID: O75533

Entrez ID: 23451

Protein name: Splicing factor 3B subunit 1 (Pre-mRNA-splicing factor SF3b 155 kDa subunit) (SF3b155) (Spliceosome-associated protein 155) (SAP 155)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SF3B1 in