DegronMD

Uniprot ID: O75533

Source protein: Splicing factor 3B subunit 1

Source gene: SF3B1

Class: DEG_SCF_FBW7_1

Location: 256:261

E3 ligase: FBXW7

DEGRON score: 0.9969

ASA_SCORE: 83.7833

COIL: 0.9507

CONS_SCORE: 0.3297

DSS_SCORE: 0.7547

HELIX: 0.0208

FCONS_SCORE: 1.0559

RIG_SCORE: 0.6121

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P258L	TCGA-DM-A1HB	COAD	TCGA	PTPSHT	DEG_SCF_FBW7_1	0.7582
p.T267N	TCGA-DW-7834	KIRP	TCGA	PTPSHT	DEG_SCF_FBW7_1	0.6111
p.T267N	DO20794	KIRP	ICGC	PTPSHT	DEG_SCF_FBW7_1	0.6111
p.D255N	TCGA-DK-A3X1	BLCA	TCGA	PTPSHT	DEG_SCF_FBW7_1	0.3056
p.D255N	DO447	BLCA	ICGC	PTPSHT	DEG_SCF_FBW7_1	0.3056
p.P262L	DO46329	OV	ICGC	PTPSHT	DEG_SCF_FBW7_1	0.3056
p.A263V	SIDM00481	Ovarian Carcinoma	GDSC	PTPSHT	DEG_SCF_FBW7_1	0.2778
p.A263V	OAW-28	ovary	COSMIC	PTPSHT	DEG_SCF_FBW7_1	0.2778
p.A247E	DO229026	LICA	ICGC	PTPSHT	DEG_SCF_FBW7_1	0.0833
p.A247E	DO229032	LICA	ICGC	PTPSHT	DEG_SCF_FBW7_1	0.0833

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75533	Splicing factor 3B subunit 1	DEG_SCF_FBW7_1	256:261	PTPSHT	FBXW7	0.9969	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons