DegronMD

Uniprot ID: O75533

Source protein: Splicing factor 3B subunit 1

Source gene: SF3B1

Class: DEG_SCF_FBW7_1

Location: 351:358

E3 ligase: FBXW7

DEGRON score: 0.9688

ASA_SCORE: 85.075

COIL: 0.9444

CONS_SCORE: 0.2849

DSS_SCORE: 0.6998

HELIX: 0.0116

FCONS_SCORE: 0.7776

RIG_SCORE: 0.6414

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P351T	TCGA-66-2734	LUSC	TCGA	PVLTPGKT	DEG_SCF_FBW7_1	0.7031
p.P351T	DO26430	LUSC	ICGC	PVLTPGKT	DEG_SCF_FBW7_1	0.7031
p.A368T	TCGA-AJ-A3EK	UCEC	TCGA	PVLTPGKT	DEG_SCF_FBW7_1	0.0556
p.A368T	DO41584	UCEC	ICGC	PVLTPGKT	DEG_SCF_FBW7_1	0.0556
p.A368T	SIDM02050	Colorectal Carcinoma	GDSC	PVLTPGKT	DEG_SCF_FBW7_1	0.0556
p.A368D	TCGA-VQ-A8P2	STAD	TCGA	PVLTPGKT	DEG_SCF_FBW7_1	0.0556
p.A368D	DO51761	STAD	ICGC	PVLTPGKT	DEG_SCF_FBW7_1	0.0556
p.P351L	TCGA-WE-A8K5	SKCM	TCGA	PVLTPGKT	DEG_SCF_FBW7_1	0.6471
p.P351L	DO51282	SKCM	ICGC	PVLTPGKT	DEG_SCF_FBW7_1	0.6471
p.P351S	TCGA-WE-A8K5	SKCM	TCGA	PVLTPGKT	DEG_SCF_FBW7_1	0.6752
p.P351S	DO51282	SKCM	ICGC	PVLTPGKT	DEG_SCF_FBW7_1	0.6752
p.G347S	DO233882	GACA	ICGC	PVLTPGKT	DEG_SCF_FBW7_1	0.2222
p.T354N	DO228948	LICA	ICGC	PVLTPGKT	DEG_SCF_FBW7_1	0.8166
p.A364D	DO229027	LICA	ICGC	PVLTPGKT	DEG_SCF_FBW7_1	0.1667
p.A364D	DO229026	LICA	ICGC	PVLTPGKT	DEG_SCF_FBW7_1	0.1667
p.P342T	DO229027	LICA	ICGC	PVLTPGKT	DEG_SCF_FBW7_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75533	Splicing factor 3B subunit 1	DEG_SCF_FBW7_1	351:358	PVLTPGKT	FBXW7	0.9688	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons