DegronMD

Uniprot ID: O75533

Source protein: Splicing factor 3B subunit 1

Source gene: SF3B1

Class: LIG_APCC_ABBA_1

Location: 133:138

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.999

ASA_SCORE: 52.9

COIL: 0.7827

CONS_SCORE: 0.3668

DSS_SCORE: 0.6387

HELIX: 0.1752

FCONS_SCORE: 1.0297

RIG_SCORE: 0.6705

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R124L	TCGA-49-AAR4	LUAD	TCGA	LDPFAD	LIG_APCC_ABBA_1	0.0833
p.R124L	DO218920	LUAD	ICGC	LDPFAD	LIG_APCC_ABBA_1	0.0833
p.G139E	TCGA-AP-A1DK	UCEC	TCGA	LDPFAD	LIG_APCC_ABBA_1	0.3056
p.G139E	DO42033	UCEC	ICGC	LDPFAD	LIG_APCC_ABBA_1	0.3056
p.R124Q	TCGA-AX-A1CE	UCEC	TCGA	LDPFAD	LIG_APCC_ABBA_1	0.0833
p.R124Q	DO42280	UCEC	ICGC	LDPFAD	LIG_APCC_ABBA_1	0.0833
p.M147V	TCGA-AX-A2H8	UCEC	TCGA	LDPFAD	LIG_APCC_ABBA_1	0.0833
p.M147V	DO43674	UCEC	ICGC	LDPFAD	LIG_APCC_ABBA_1	0.0833
p.G140W	TCGA-CV-7252	HNSC	TCGA	LDPFAD	LIG_APCC_ABBA_1	0.2778
p.G140W	DO14176	HNSC	ICGC	LDPFAD	LIG_APCC_ABBA_1	0.2778
p.P135S	TCGA-EE-A2MJ	SKCM	TCGA	LDPFAD	LIG_APCC_ABBA_1	0.6752
p.P135S	DO38099	SKCM	ICGC	LDPFAD	LIG_APCC_ABBA_1	0.6752
p.I128F	DO227657	COCA	ICGC	LDPFAD	LIG_APCC_ABBA_1	0.1944
p.I127T	DO222762	COCA	ICGC	LDPFAD	LIG_APCC_ABBA_1	0.1667
p.A144T	DO229010	COCA	ICGC	LDPFAD	LIG_APCC_ABBA_1	0.1667
p.T125N	DO229035	LICA	ICGC	LDPFAD	LIG_APCC_ABBA_1	0.5556
p.M126I	DO231026	LUSC	ICGC	LDPFAD	LIG_APCC_ABBA_1	0.1389
p.R132C	DO228138	PBCA	ICGC	LDPFAD	LIG_APCC_ABBA_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75061	Putative tyrosine-protein phosphatase auxilin	LIG_APCC_ABBA_1	676:681	LDPFAD	APC,CDC20,FZR1	0.7971	More...
O75533	Splicing factor 3B subunit 1	LIG_APCC_ABBA_1	133:138	LDPFAD	APC,CDC20,FZR1	0.999	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons