DegronMD - O75061(DNAJC6)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G385V	TCGA-34-5239	LUSC	TCGA	IDLTPPWE	DEG_SCF_FBW7_2	372:379	Mutation rewiring degron network	0.1667
p.S567I	TCGA-56-8622	LUSC	TCGA	ATSTS	DEG_SPOP_SBC_1	564:568	Mutation altering degron motif	0.7341
p.L668F	TCGA-A5-A2K5	UCEC	TCGA	LDPFAD	LIG_APCC_ABBA_1	676:681	Mutation rewiring degron network	0.1111
p.L668F	TCGA-ER-A19G	SKCM	TCGA	LDPFAD	LIG_APCC_ABBA_1	676:681	Mutation rewiring degron network	0.1111
p.S675L	TCGA-AJ-A3BD	UCEC	TCGA	LDPFAD	LIG_APCC_ABBA_1	676:681	Mutation rewiring degron network	0.3056
p.A563V	TCGA-AX-A0J1	UCEC	TCGA	ATSTS	DEG_SPOP_SBC_1	564:568	Mutation blocking phosphorylation signal	0.75
p.P674H	TCGA-AX-A1CE	UCEC	TCGA	LDPFAD	LIG_APCC_ABBA_1	676:681	Mutation rewiring degron network	0.2778
p.A572V	TCGA-CM-6171	COAD	TCGA	ATSTS	DEG_SPOP_SBC_1	564:568	Mutation blocking phosphorylation signal	0.6667
p.A572V	TCGA-CV-A6JT	HNSC	TCGA	ATSTS	DEG_SPOP_SBC_1	564:568	Mutation blocking phosphorylation signal	0.6667
p.P674L	TCGA-D3-A1Q6	SKCM	TCGA	LDPFAD	LIG_APCC_ABBA_1	676:681	Mutation rewiring degron network	0.2778
p.K371N	TCGA-D3-A2JC	SKCM	TCGA	IDLTPPWE	DEG_SCF_FBW7_2	372:379	Mutation rewiring degron network	0.3056
p.R367W	TCGA-D7-A4YV	STAD	TCGA	IDLTPPWE	DEG_SCF_FBW7_2	372:379	Mutation rewiring degron network	0.1944
p.S567N	TCGA-FI-A2D5	UCEC	TCGA	ATSTS	DEG_SPOP_SBC_1	564:568	Mutation altering degron motif	0.7069
p.N687S	TCGA-FI-A2D5	UCEC	TCGA	LDPFAD	LIG_APCC_ABBA_1	676:681	Mutation rewiring degron network	0.1667
p.Q669R	TCGA-K4-A83P	BLCA	TCGA	LDPFAD	LIG_APCC_ABBA_1	676:681	Mutation rewiring degron network	0.1389
p.D668Y	DO48504	BLCA	ICGC	LDPFAD	LIG_APCC_ABBA_1	676:681	Mutation rewiring degron network	0.1111
p.R561T	DO224732	BRCA	ICGC	ATSTS	DEG_SPOP_SBC_1	564:568	Mutation rewiring degron network	0.25
p.S676C	DO228506	BRCA	ICGC	LDPFAD	LIG_APCC_ABBA_1	676:681	Mutation altering degron motif	0.7541
p.P684L	DO51729	COAD	ICGC	LDPFAD	LIG_APCC_ABBA_1	676:681	Mutation rewiring degron network	0.25
p.A667S	DO229045	LICA	ICGC	LDPFAD	LIG_APCC_ABBA_1	676:681	Mutation rewiring degron network	0.0833
p.P577S	DO222354	LICA	ICGC	ATSTS	DEG_SPOP_SBC_1	564:568	Mutation rewiring degron network	0.0833
p.T388M	DO45360	LUAD	ICGC	IDLTPPWE	DEG_SCF_FBW7_2	372:379	Mutation rewiring degron network	0.0833
p.T388M	DO26437	LUSC	ICGC	IDLTPPWE	DEG_SCF_FBW7_2	372:379	Mutation rewiring degron network	0.0833
p.S376G	DO26608	LUSC	ICGC	IDLTPPWE	DEG_SCF_FBW7_2	372:379	Mutation altering degron motif	0.6993
p.S676F	DO220903	MELA	ICGC	LDPFAD	LIG_APCC_ABBA_1	676:681	Mutation altering degron motif	0.7982
p.S557F	DO222843	MELA	ICGC	ATSTS	DEG_SPOP_SBC_1	564:568	Mutation rewiring degron network	0.1389
p.D668N	DO32347	OV	ICGC	LDPFAD	LIG_APCC_ABBA_1	676:681	Mutation rewiring degron network	0.1111
p.G688V	DO35132	PACA	ICGC	LDPFAD	LIG_APCC_ABBA_1	676:681	Mutation rewiring degron network	0.1389
p.K680R	DO48550	SKCM	ICGC	LDPFAD	LIG_APCC_ABBA_1	676:681	Mutation altering degron motif	0.7237
p.S380A	DO37499	SKCM	ICGC	IDLTPPWE	DEG_SCF_FBW7_2	372:379	Mutation rewiring degron network	0.3056
p.P681H	DO37443	SKCM	ICGC	LDPFAD	LIG_APCC_ABBA_1	676:681	Mutation altering degron motif	0.7694
p.L378F	DO50284	SKCM	ICGC	IDLTPPWE	DEG_SCF_FBW7_2	372:379	Mutation altering degron motif	0.6981
p.L378I	DO38823	STAD	ICGC	IDLTPPWE	DEG_SCF_FBW7_2	372:379	Mutation altering degron motif	0.7174
p.S679R	DO229224	THCA	ICGC	LDPFAD	LIG_APCC_ABBA_1	676:681	Mutation altering degron motif	0.7427
p.S675F	DO219773	UCEC	ICGC	LDPFAD	LIG_APCC_ABBA_1	676:681	Mutation rewiring degron network	0.3056
p.R561I	DO43186	UCEC	ICGC	ATSTS	DEG_SPOP_SBC_1	564:568	Mutation rewiring degron network	0.25
p.F379L	DO41211	UCEC	ICGC	IDLTPPWE	DEG_SCF_FBW7_2	372:379	Mutation altering degron motif	0.6981
p.P666S	SIDM00596	Endometrial Carcinoma	GDSC	LDPFAD	LIG_APCC_ABBA_1	676:681	Mutation rewiring degron network	0.0556
p.P666S	ACH-000941	Endometrial/Uterine Cancer	CCLE	LDPFAD	LIG_APCC_ABBA_1	676:681	Mutation rewiring degron network	0.0556
p.P666S	ACH-001517	Endometrial/Uterine Cancer	CCLE	LDPFAD	LIG_APCC_ABBA_1	676:681	Mutation rewiring degron network	0.0556
p.P666S	HEC-1	endometrium	COSMIC	LDPFAD	LIG_APCC_ABBA_1	676:681	Mutation rewiring degron network	0.0556
p.S682G	SIDM00925	Non-Small Cell Lung Carcinoma	GDSC	LDPFAD	LIG_APCC_ABBA_1	676:681	Mutation rewiring degron network	0.3056
p.S682G	ACH-000638	Lung Cancer	CCLE	LDPFAD	LIG_APCC_ABBA_1	676:681	Mutation rewiring degron network	0.3056
p.S682G	NCI-H441	lung	COSMIC	LDPFAD	LIG_APCC_ABBA_1	676:681	Mutation rewiring degron network	0.3056
p.H679Y	SIDM00833	Colorectal Carcinoma	GDSC	LDPFAD	LIG_APCC_ABBA_1	676:681	Mutation altering degron motif	0.7229
p.H679Y	ACH-000421	Colon/Colorectal Cancer	CCLE	LDPFAD	LIG_APCC_ABBA_1	676:681	Mutation altering degron motif	0.7229
p.H679Y	SW837	large intestine	COSMIC	LDPFAD	LIG_APCC_ABBA_1	676:681	Mutation altering degron motif	0.7229
p.A680G	SIDM00706	Small Cell Lung Carcinoma	GDSC	LDPFAD	LIG_APCC_ABBA_1	676:681	Mutation altering degron motif	0.6429
p.A680G	NCI-H209	lung	COSMIC	LDPFAD	LIG_APCC_ABBA_1	676:681	Mutation altering degron motif	0.6429
p.R561H	HEC-1	endometrium	COSMIC	ATSTS	DEG_SPOP_SBC_1	564:568	Mutation rewiring degron network	0.25
p.S578P	L-1236	haematopoietic and lymphoid tissue	COSMIC	ATSTS	DEG_SPOP_SBC_1	564:568	Mutation rewiring degron network	0.0556
p.E384K	HCC-33	lung	COSMIC	IDLTPPWE	DEG_SCF_FBW7_2	372:379	Mutation substituting flanking lysine	0.3056
p.G688D	NCI-H1355	lung	COSMIC	LDPFAD	LIG_APCC_ABBA_1	676:681	Mutation rewiring degron network	0.1389
p.P667A	KMH-2	thyroid	COSMIC	LDPFAD	LIG_APCC_ABBA_1	676:681	Mutation rewiring degron network	0.0833
p.T682N	SNU-C5	large intestine	COSMIC	LDPFAD	LIG_APCC_ABBA_1	676:681	Mutation rewiring degron network	0.3056
p.S563Y	SK-LU-1	lung	COSMIC	ATSTS	DEG_SPOP_SBC_1	564:568	Mutation blocking phosphorylation signal	0.75

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DNAJC6

UniProt ID: O75061

Entrez ID: 9829

Protein name: Putative tyrosine-protein phosphatase auxilin (EC 3.1.3.48) (DnaJ homolog subfamily C member 6)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DNAJC6 in