DegronMD

Uniprot ID: O75061

Source protein: Putative tyrosine-protein phosphatase auxilin

Source gene: DNAJC6

Class: DEG_SCF_FBW7_2

Location: 372:379

E3 ligase: FBXW7

DEGRON score: 0.5793

ASA_SCORE: 82.65

COIL: 0.852

CONS_SCORE: 0.4264

DSS_SCORE: 0.3122

HELIX: 0.096

FCONS_SCORE: 0.8831

RIG_SCORE: 0.7885

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G385V	TCGA-34-5239	LUSC	TCGA	IDLTPPWE	DEG_SCF_FBW7_2	0.1667
p.K371N	TCGA-D3-A2JC	SKCM	TCGA	IDLTPPWE	DEG_SCF_FBW7_2	0.3056
p.R367W	TCGA-D7-A4YV	STAD	TCGA	IDLTPPWE	DEG_SCF_FBW7_2	0.1944
p.T388M	DO45360	LUAD	ICGC	IDLTPPWE	DEG_SCF_FBW7_2	0.0833
p.T388M	DO26437	LUSC	ICGC	IDLTPPWE	DEG_SCF_FBW7_2	0.0833
p.S376G	DO26608	LUSC	ICGC	IDLTPPWE	DEG_SCF_FBW7_2	0.6993
p.S380A	DO37499	SKCM	ICGC	IDLTPPWE	DEG_SCF_FBW7_2	0.3056
p.L378F	DO50284	SKCM	ICGC	IDLTPPWE	DEG_SCF_FBW7_2	0.6981
p.L378I	DO38823	STAD	ICGC	IDLTPPWE	DEG_SCF_FBW7_2	0.7174
p.F379L	DO41211	UCEC	ICGC	IDLTPPWE	DEG_SCF_FBW7_2	0.6981
p.E384K	HCC-33	lung	COSMIC	IDLTPPWE	DEG_SCF_FBW7_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75061	Putative tyrosine-protein phosphatase auxilin	DEG_SCF_FBW7_2	372:379	IDLTPPWE	FBXW7	0.5793	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons