DegronMD

Uniprot ID: O75061

Source protein: Putative tyrosine-protein phosphatase auxilin

Source gene: DNAJC6

Class: LIG_APCC_ABBA_1

Location: 676:681

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7971

ASA_SCORE: 70.85

COIL: 0.7197

CONS_SCORE: 0.4281

DSS_SCORE: 0.6577

HELIX: 0.2293

FCONS_SCORE: 0.9357

RIG_SCORE: 0.7454

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L668F	TCGA-A5-A2K5	UCEC	TCGA	LDPFAD	LIG_APCC_ABBA_1	0.1111
p.L668F	TCGA-ER-A19G	SKCM	TCGA	LDPFAD	LIG_APCC_ABBA_1	0.1111
p.S675L	TCGA-AJ-A3BD	UCEC	TCGA	LDPFAD	LIG_APCC_ABBA_1	0.3056
p.P674H	TCGA-AX-A1CE	UCEC	TCGA	LDPFAD	LIG_APCC_ABBA_1	0.2778
p.P674L	TCGA-D3-A1Q6	SKCM	TCGA	LDPFAD	LIG_APCC_ABBA_1	0.2778
p.N687S	TCGA-FI-A2D5	UCEC	TCGA	LDPFAD	LIG_APCC_ABBA_1	0.1667
p.Q669R	TCGA-K4-A83P	BLCA	TCGA	LDPFAD	LIG_APCC_ABBA_1	0.1389
p.D668Y	DO48504	BLCA	ICGC	LDPFAD	LIG_APCC_ABBA_1	0.1111
p.S676C	DO228506	BRCA	ICGC	LDPFAD	LIG_APCC_ABBA_1	0.7541
p.P684L	DO51729	COAD	ICGC	LDPFAD	LIG_APCC_ABBA_1	0.25
p.A667S	DO229045	LICA	ICGC	LDPFAD	LIG_APCC_ABBA_1	0.0833
p.S676F	DO220903	MELA	ICGC	LDPFAD	LIG_APCC_ABBA_1	0.7982
p.D668N	DO32347	OV	ICGC	LDPFAD	LIG_APCC_ABBA_1	0.1111
p.G688V	DO35132	PACA	ICGC	LDPFAD	LIG_APCC_ABBA_1	0.1389
p.K680R	DO48550	SKCM	ICGC	LDPFAD	LIG_APCC_ABBA_1	0.7237
p.P681H	DO37443	SKCM	ICGC	LDPFAD	LIG_APCC_ABBA_1	0.7694
p.S679R	DO229224	THCA	ICGC	LDPFAD	LIG_APCC_ABBA_1	0.7427
p.S675F	DO219773	UCEC	ICGC	LDPFAD	LIG_APCC_ABBA_1	0.3056
p.P666S	SIDM00596	Endometrial Carcinoma	GDSC	LDPFAD	LIG_APCC_ABBA_1	0.0556
p.P666S	ACH-000941	Endometrial/Uterine Cancer	CCLE	LDPFAD	LIG_APCC_ABBA_1	0.0556
p.P666S	ACH-001517	Endometrial/Uterine Cancer	CCLE	LDPFAD	LIG_APCC_ABBA_1	0.0556
p.P666S	HEC-1	endometrium	COSMIC	LDPFAD	LIG_APCC_ABBA_1	0.0556
p.S682G	SIDM00925	Non-Small Cell Lung Carcinoma	GDSC	LDPFAD	LIG_APCC_ABBA_1	0.3056
p.S682G	ACH-000638	Lung Cancer	CCLE	LDPFAD	LIG_APCC_ABBA_1	0.3056
p.S682G	NCI-H441	lung	COSMIC	LDPFAD	LIG_APCC_ABBA_1	0.3056
p.H679Y	SIDM00833	Colorectal Carcinoma	GDSC	LDPFAD	LIG_APCC_ABBA_1	0.7229
p.H679Y	ACH-000421	Colon/Colorectal Cancer	CCLE	LDPFAD	LIG_APCC_ABBA_1	0.7229
p.H679Y	SW837	large_intestine	COSMIC	LDPFAD	LIG_APCC_ABBA_1	0.7229
p.A680G	SIDM00706	Small Cell Lung Carcinoma	GDSC	LDPFAD	LIG_APCC_ABBA_1	0.6429
p.A680G	NCI-H209	lung	COSMIC	LDPFAD	LIG_APCC_ABBA_1	0.6429
p.G688D	NCI-H1355	lung	COSMIC	LDPFAD	LIG_APCC_ABBA_1	0.1389
p.P667A	KMH-2	thyroid	COSMIC	LDPFAD	LIG_APCC_ABBA_1	0.0833
p.T682N	SNU-C5	large_intestine	COSMIC	LDPFAD	LIG_APCC_ABBA_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75061	Putative tyrosine-protein phosphatase auxilin	LIG_APCC_ABBA_1	676:681	LDPFAD	APC,CDC20,FZR1	0.7971	More...
O75533	Splicing factor 3B subunit 1	LIG_APCC_ABBA_1	133:138	LDPFAD	APC,CDC20,FZR1	0.999	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LDPFAD

Degron related mutations and impact score

Drug responses associated with DNAJC6 mutations

All proteins holding degron of LDPFAD