DegronMD

Uniprot ID: O75061

Source protein: Putative tyrosine-protein phosphatase auxilin

Source gene: DNAJC6

Class: DEG_SPOP_SBC_1

Location: 564:568

E3 ligase: SPOP

DEGRON score: 0.9989

ASA_SCORE: 79.64

COIL: 0.9294

CONS_SCORE: 0.4401

DSS_SCORE: 0.7027

HELIX: 0.0464

FCONS_SCORE: 1.049

RIG_SCORE: 0.6008

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S567I	TCGA-56-8622	LUSC	TCGA	ATSTS	DEG_SPOP_SBC_1	0.7341
p.A563V	TCGA-AX-A0J1	UCEC	TCGA	ATSTS	DEG_SPOP_SBC_1	0.75
p.A572V	TCGA-CM-6171	COAD	TCGA	ATSTS	DEG_SPOP_SBC_1	0.6667
p.A572V	TCGA-CV-A6JT	HNSC	TCGA	ATSTS	DEG_SPOP_SBC_1	0.6667
p.S567N	TCGA-FI-A2D5	UCEC	TCGA	ATSTS	DEG_SPOP_SBC_1	0.7069
p.R561T	DO224732	BRCA	ICGC	ATSTS	DEG_SPOP_SBC_1	0.25
p.P577S	DO222354	LICA	ICGC	ATSTS	DEG_SPOP_SBC_1	0.0833
p.S557F	DO222843	MELA	ICGC	ATSTS	DEG_SPOP_SBC_1	0.1389
p.R561I	DO43186	UCEC	ICGC	ATSTS	DEG_SPOP_SBC_1	0.25
p.R561H	HEC-1	endometrium	COSMIC	ATSTS	DEG_SPOP_SBC_1	0.25
p.S578P	L-1236	haematopoietic_and_lymphoid_tissue	COSMIC	ATSTS	DEG_SPOP_SBC_1	0.0556
p.S563Y	SK-LU-1	lung	COSMIC	ATSTS	DEG_SPOP_SBC_1	0.75

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43167	Zinc finger and BTB domain-containing protein 24	DEG_SPOP_SBC_1	661:665	ATSTS	SPOP	0.8818	More...
O75061	Putative tyrosine-protein phosphatase auxilin	DEG_SPOP_SBC_1	564:568	ATSTS	SPOP	0.9989	More...
P51826	AF4/FMR2 family member 3	DEG_SPOP_SBC_1	846:850	ATSTS	SPOP	0.9984	More...
Q12830	Nucleosome-remodeling factor subunit BPTF	DEG_SPOP_SBC_1	2250:2254	ATSTS	SPOP	0.9964	More...
Q13164	Mitogen-activated protein kinase 7	DEG_SPOP_SBC_1	658:662	ATSTS	SPOP	0.6439	More...
Q3T8J9	GON-4-like protein	DEG_SPOP_SBC_1	2218:2222	ATSTS	SPOP	0.6171	More...
Q6W4X9	Mucin-6	DEG_SPOP_SBC_1	1706:1710	ATSTS	SPOP	0.8956	More...
Q70CQ4	Ubiquitin carboxyl-terminal hydrolase 31	DEG_SPOP_SBC_1	1170:1174	ATSTS	SPOP	0.9971	More...
Q8IYB3	Serine/arginine repetitive matrix protein 1	DEG_SPOP_SBC_1	238:242	ATSTS	SPOP	0.9886	More...
Q96IZ7	Serine/Arginine-related protein 53	DEG_SPOP_SBC_1	263:267	ATSTS	SPOP	0.9754	More...
Q9NQC1	E3 ubiquitin-protein ligase Jade-2	DEG_SPOP_SBC_1	22:26	ATSTS	SPOP	0.9861	More...
Q9NQG7	Hermansky-Pudlak syndrome 4 protein	DEG_SPOP_SBC_1	2:6	ATSTS	SPOP	0.7449	More...
Q9NR71	Neutral ceramidase	DEG_SPOP_SBC_1	701:705	ATSTS	SPOP	0.7751	More...
Q9NZM3	Intersectin-2	DEG_SPOP_SBC_1	840:844	ATSTS	SPOP	0.7206	More...
Q9UKL3	CASP8-associated protein 2	DEG_SPOP_SBC_1	1908:1912	ATSTS	SPOP	0.702	More...
Q9Y520	Protein PRRC2C	DEG_SPOP_SBC_1	2690:2694	ATSTS	SPOP	0.9814	More...
Q9Y5P4	Ceramide transfer protein	DEG_SPOP_SBC_1	145:149	ATSTS	SPOP	0.9864	More...
Q96T17	MAP7 domain-containing protein 2	DEG_SPOP_SBC_1	229:233	ATSTS	SPOP	0.9487	More...
Q9H195	Mucin-3B	DEG_SPOP_SBC_1	26:30	ATSTS	SPOP	0.881	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ATSTS

Degron related mutations and impact score

Drug responses associated with DNAJC6 mutations

All proteins holding degron of ATSTS