DegronMD - Q3T8J9(GON4L)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P1397S	TCGA-43-5668	LUSC	TCGA	PTKTPSSS	DEG_SCF_FBW7_1	1386:1393	Mutation rewiring degron network	0.2222
p.P1397S	DO26608	LUSC	ICGC	PTKTPSSS	DEG_SCF_FBW7_1	1386:1393	Mutation rewiring degron network	0.2222
p.D1398H	TCGA-55-A4DF	LUAD	TCGA	PTKTPSSS	DEG_SCF_FBW7_1	1386:1393	Mutation rewiring degron network	0.1944
p.D1398H	DO45318	LUAD	ICGC	PTKTPSSS	DEG_SCF_FBW7_1	1386:1393	Mutation rewiring degron network	0.1944
p.S1011C	TCGA-5N-A9KI	BLCA	TCGA	PGKTPARS	DEG_SCF_FBW7_1	1018:1025	Mutation rewiring degron network	0.1389
p.S1011C	DO223513	BLCA	ICGC	PGKTPARS	DEG_SCF_FBW7_1	1018:1025	Mutation rewiring degron network	0.1389
p.V1292I	TCGA-62-A46O	LUAD	TCGA	GRQALEPLP	DEG_APCC_DBOX_1	1298:1306	Mutation rewiring degron network	0.1667
p.V1292I	DO26240	LUAD	ICGC	GRQALEPLP	DEG_APCC_DBOX_1	1298:1306	Mutation rewiring degron network	0.1667
p.V1292I	SIDM01314	Colorectal Carcinoma	GDSC	GRQALEPLP	DEG_APCC_DBOX_1	1298:1306	Mutation rewiring degron network	0.1667
p.S801R	TCGA-A6-3809	COAD	TCGA	VFMYPE	LIG_APCC_ABBA_1	803:808	Mutation rewiring degron network	0.2778
p.S801R	TCGA-A6-3809	COAD	TCGA	KVFMYPE	LIG_APCC_ABBAyCdc20_2	802:808	Mutation rewiring degron network	0.3056
p.S801R	DO8722	COAD	ICGC	VFMYPE	LIG_APCC_ABBA_1	803:808	Mutation rewiring degron network	0.2778
p.S801R	DO8722	COAD	ICGC	KVFMYPE	LIG_APCC_ABBAyCdc20_2	802:808	Mutation rewiring degron network	0.3056
p.F1016S	TCGA-AA-3984	COAD	TCGA	PGKTPARS	DEG_SCF_FBW7_1	1018:1025	Mutation rewiring degron network	0.2778
p.F1016S	DO9002	COAD	ICGC	PGKTPARS	DEG_SCF_FBW7_1	1018:1025	Mutation rewiring degron network	0.2778
p.S1009I	TCGA-AP-A0LM	UCEC	TCGA	PGKTPARS	DEG_SCF_FBW7_1	1018:1025	Mutation blocking phosphorylation signal	0.5278
p.S1009I	DO43306	UCEC	ICGC	PGKTPARS	DEG_SCF_FBW7_1	1018:1025	Mutation blocking phosphorylation signal	0.5278
p.D1474Y	TCGA-AP-A1DV	UCEC	TCGA	SEESVLSVPEL	DEG_COP1_1	1480:1490	Mutation rewiring degron network	0.1667
p.D1474Y	DO43186	UCEC	ICGC	SEESVLSVPEL	DEG_COP1_1	1480:1490	Mutation rewiring degron network	0.1667
p.K818N	TCGA-B5-A11E	UCEC	TCGA	VFMYPE	LIG_APCC_ABBA_1	803:808	Mutation substituting flanking lysine	0.1667
p.K818N	TCGA-B5-A11E	UCEC	TCGA	KVFMYPE	LIG_APCC_ABBAyCdc20_2	802:808	Mutation substituting flanking lysine	0.1667
p.K818N	DO41644	UCEC	ICGC	VFMYPE	LIG_APCC_ABBA_1	803:808	Mutation substituting flanking lysine	0.1667
p.K818N	DO41644	UCEC	ICGC	KVFMYPE	LIG_APCC_ABBAyCdc20_2	802:808	Mutation substituting flanking lysine	0.1667
p.V812M	TCGA-B5-A3FA	UCEC	TCGA	VFMYPE	LIG_APCC_ABBA_1	803:808	Mutation rewiring degron network	0.2222
p.V812M	TCGA-B5-A3FA	UCEC	TCGA	KVFMYPE	LIG_APCC_ABBAyCdc20_2	802:808	Mutation rewiring degron network	0.2222
p.V812M	DO52402	UCEC	ICGC	VFMYPE	LIG_APCC_ABBA_1	803:808	Mutation rewiring degron network	0.2222
p.V812M	DO52402	UCEC	ICGC	KVFMYPE	LIG_APCC_ABBAyCdc20_2	802:808	Mutation rewiring degron network	0.2222
p.S1477L	TCGA-BH-A1FL	BRCA	TCGA	SEESVLSVPEL	DEG_COP1_1	1480:1490	Mutation rewiring degron network	0.25
p.S1477L	DO5221	BRCA	ICGC	SEESVLSVPEL	DEG_COP1_1	1480:1490	Mutation rewiring degron network	0.25
p.R1289C	TCGA-D1-A0ZO	UCEC	TCGA	GRQALEPLP	DEG_APCC_DBOX_1	1298:1306	Mutation rewiring degron network	0.0833
p.R1289C	DO41927	UCEC	ICGC	GRQALEPLP	DEG_APCC_DBOX_1	1298:1306	Mutation rewiring degron network	0.0833
p.D2231E	TCGA-D1-A0ZQ	UCEC	TCGA	ATSTS	DEG_SPOP_SBC_1	2218:2222	Mutation rewiring degron network	0.0833
p.D2231E	DO41879	UCEC	ICGC	ATSTS	DEG_SPOP_SBC_1	2218:2222	Mutation rewiring degron network	0.0833
p.G1308D	TCGA-D5-6928	COAD	TCGA	GRQALEPLP	DEG_APCC_DBOX_1	1298:1306	Mutation rewiring degron network	0.2778
p.G1308D	DO7776	COAD	ICGC	GRQALEPLP	DEG_APCC_DBOX_1	1298:1306	Mutation rewiring degron network	0.2778
p.E2208K	TCGA-D8-A1JA	BRCA	TCGA	ATSTS	DEG_SPOP_SBC_1	2218:2222	Mutation rewiring degron network	0.0556
p.E2208K	DO2819	BRCA	ICGC	ATSTS	DEG_SPOP_SBC_1	2218:2222	Mutation rewiring degron network	0.0556
p.S1483F	TCGA-DK-AA6X	BLCA	TCGA	SEESVLSVPEL	DEG_COP1_1	1480:1490	Mutation altering degron motif	0.7982
p.S1483F	DO51873	BLCA	ICGC	SEESVLSVPEL	DEG_COP1_1	1480:1490	Mutation altering degron motif	0.7982
p.E1399K	TCGA-DR-A0ZM	CESC	TCGA	PTKTPSSS	DEG_SCF_FBW7_1	1386:1393	Mutation rewiring degron network	0.1667
p.E1399K	DO6254	CESC	ICGC	PTKTPSSS	DEG_SCF_FBW7_1	1386:1393	Mutation rewiring degron network	0.1667
p.G1308S	TCGA-DU-6407	LGG	TCGA	GRQALEPLP	DEG_APCC_DBOX_1	1298:1306	Mutation rewiring degron network	0.2778
p.G1308S	DO22295	LGG	ICGC	GRQALEPLP	DEG_APCC_DBOX_1	1298:1306	Mutation rewiring degron network	0.2778
p.P1306S	TCGA-EE-A17X	SKCM	TCGA	GRQALEPLP	DEG_APCC_DBOX_1	1298:1306	Mutation altering degron motif	0.5641
p.P1306S	DO37931	SKCM	ICGC	GRQALEPLP	DEG_APCC_DBOX_1	1298:1306	Mutation altering degron motif	0.5641
p.P811S	TCGA-EE-A2MR	SKCM	TCGA	VFMYPE	LIG_APCC_ABBA_1	803:808	Mutation rewiring degron network	0.25
p.P811S	TCGA-EE-A2MR	SKCM	TCGA	KVFMYPE	LIG_APCC_ABBAyCdc20_2	802:808	Mutation rewiring degron network	0.25
p.P811S	DO37819	SKCM	ICGC	VFMYPE	LIG_APCC_ABBA_1	803:808	Mutation rewiring degron network	0.25
p.P811S	DO37819	SKCM	ICGC	KVFMYPE	LIG_APCC_ABBAyCdc20_2	802:808	Mutation rewiring degron network	0.25
p.P1010L	TCGA-ER-A199	SKCM	TCGA	PGKTPARS	DEG_SCF_FBW7_1	1018:1025	Mutation rewiring degron network	0.1111
p.P1010L	DO47395	SKCM	ICGC	PGKTPARS	DEG_SCF_FBW7_1	1018:1025	Mutation rewiring degron network	0.1111
p.P1010L	SIDM00374	B-Cell Non-Hodgkin's Lymphoma	GDSC	PGKTPARS	DEG_SCF_FBW7_1	1018:1025	Mutation rewiring degron network	0.1111
p.P1010L	SIDM00589	Oral Cavity Carcinoma	GDSC	PGKTPARS	DEG_SCF_FBW7_1	1018:1025	Mutation rewiring degron network	0.1111
p.P1010L	SIDM00564	Ovarian Carcinoma	GDSC	PGKTPARS	DEG_SCF_FBW7_1	1018:1025	Mutation rewiring degron network	0.1111
p.P1010L	SIDM00986	Head and Neck Carcinoma	GDSC	PGKTPARS	DEG_SCF_FBW7_1	1018:1025	Mutation rewiring degron network	0.1111
p.P1010L	SIDM01574	Plasma Cell Myeloma	GDSC	PGKTPARS	DEG_SCF_FBW7_1	1018:1025	Mutation rewiring degron network	0.1111
p.P1010L	ACH-000527	Ovarian Cancer	CCLE	PGKTPARS	DEG_SCF_FBW7_1	1018:1025	Mutation rewiring degron network	0.1111
p.P1010L	ACH-000548	Head and Neck Cancer	CCLE	PGKTPARS	DEG_SCF_FBW7_1	1018:1025	Mutation rewiring degron network	0.1111
p.P1010L	ACH-000588	Myeloma	CCLE	PGKTPARS	DEG_SCF_FBW7_1	1018:1025	Mutation rewiring degron network	0.1111
p.P1010L	ACH-000778	Head and Neck Cancer	CCLE	PGKTPARS	DEG_SCF_FBW7_1	1018:1025	Mutation rewiring degron network	0.1111
p.P1010L	ACH-002062	Lymphoma	CCLE	PGKTPARS	DEG_SCF_FBW7_1	1018:1025	Mutation rewiring degron network	0.1111
p.P1010L	OVISE	ovary	COSMIC	PGKTPARS	DEG_SCF_FBW7_1	1018:1025	Mutation rewiring degron network	0.1111
p.P1010L	HSC-3	upper aerodigestive tract	COSMIC	PGKTPARS	DEG_SCF_FBW7_1	1018:1025	Mutation rewiring degron network	0.1111
p.P1010L	BHY	upper aerodigestive tract	COSMIC	PGKTPARS	DEG_SCF_FBW7_1	1018:1025	Mutation rewiring degron network	0.1111
p.P1010L	SLVL	haematopoietic and lymphoid tissue	COSMIC	PGKTPARS	DEG_SCF_FBW7_1	1018:1025	Mutation rewiring degron network	0.1111
p.P1031H	TCGA-FI-A2F4	UCEC	TCGA	PGKTPARS	DEG_SCF_FBW7_1	1018:1025	Mutation rewiring degron network	0.1667
p.P1031H	DO43434	UCEC	ICGC	PGKTPARS	DEG_SCF_FBW7_1	1018:1025	Mutation rewiring degron network	0.1667
p.E1481Q	TCGA-IR-A3LK	CESC	TCGA	SEESVLSVPEL	DEG_COP1_1	1480:1490	Mutation altering degron motif	0.5633
p.E1481Q	DO44299	CESC	ICGC	SEESVLSVPEL	DEG_COP1_1	1480:1490	Mutation altering degron motif	0.5633
p.D1471N	TCGA-LN-A9FQ	ESCA	TCGA	SEESVLSVPEL	DEG_COP1_1	1480:1490	Mutation rewiring degron network	0.0833
p.G1400R	TCGA-PL-A8LV	BRCA	TCGA	PTKTPSSS	DEG_SCF_FBW7_1	1386:1393	Mutation rewiring degron network	0.1389
p.G1400R	DO51215	BRCA	ICGC	PTKTPSSS	DEG_SCF_FBW7_1	1386:1393	Mutation rewiring degron network	0.1389
p.P1031S	TCGA-QC-A7B5	SARC	TCGA	PGKTPARS	DEG_SCF_FBW7_1	1018:1025	Mutation rewiring degron network	0.1667
p.P1031S	DO220239	SARC	ICGC	PGKTPARS	DEG_SCF_FBW7_1	1018:1025	Mutation rewiring degron network	0.1667
p.E808K	TCGA-SY-A9G5	BLCA	TCGA	VFMYPE	LIG_APCC_ABBA_1	803:808	Mutation altering degron motif	0.7022
p.E808K	TCGA-SY-A9G5	BLCA	TCGA	KVFMYPE	LIG_APCC_ABBAyCdc20_2	802:808	Mutation altering degron motif	0.7022
p.E808K	DO51906	BLCA	ICGC	VFMYPE	LIG_APCC_ABBA_1	803:808	Mutation altering degron motif	0.7022
p.E808K	DO51906	BLCA	ICGC	KVFMYPE	LIG_APCC_ABBAyCdc20_2	802:808	Mutation altering degron motif	0.7022
p.E1472K	TCGA-ZF-AA54	BLCA	TCGA	SEESVLSVPEL	DEG_COP1_1	1480:1490	Mutation rewiring degron network	0.1111
p.E1472K	DO219098	BLCA	ICGC	SEESVLSVPEL	DEG_COP1_1	1480:1490	Mutation rewiring degron network	0.1111
p.K1379N	DO223016	ESCA	ICGC	PTKTPSSS	DEG_SCF_FBW7_1	1386:1393	Mutation substituting flanking lysine	0.25
p.T2220N	DO228948	LICA	ICGC	ATSTS	DEG_SPOP_SBC_1	2218:2222	Mutation altering degron motif	0.7055
p.Q1470K	DO228948	LICA	ICGC	SEESVLSVPEL	DEG_COP1_1	1480:1490	Mutation rewiring degron network	0.0556
p.P1018T	DO229019	LICA	ICGC	PGKTPARS	DEG_SCF_FBW7_1	1018:1025	Mutation altering degron motif	0.7031
p.T800K	DO229022	LICA	ICGC	VFMYPE	LIG_APCC_ABBA_1	803:808	Mutation rewiring degron network	0.25
p.T800K	DO229022	LICA	ICGC	KVFMYPE	LIG_APCC_ABBAyCdc20_2	802:808	Mutation rewiring degron network	0.2778
p.T800K	DO229232	THCA	ICGC	VFMYPE	LIG_APCC_ABBA_1	803:808	Mutation rewiring degron network	0.25
p.T800K	DO229232	THCA	ICGC	KVFMYPE	LIG_APCC_ABBAyCdc20_2	802:808	Mutation rewiring degron network	0.2778
p.A799D	DO229009	LICA	ICGC	VFMYPE	LIG_APCC_ABBA_1	803:808	Mutation rewiring degron network	0.2222
p.A799D	DO229009	LICA	ICGC	KVFMYPE	LIG_APCC_ABBAyCdc20_2	802:808	Mutation rewiring degron network	0.25
p.V1500A	DO22845	LIHC	ICGC	SEESVLSVPEL	DEG_COP1_1	1480:1490	Mutation rewiring degron network	0.0556
p.Q1378R	DO23182	LINC	ICGC	PTKTPSSS	DEG_SCF_FBW7_1	1386:1393	Mutation rewiring degron network	0.1111
p.L798Q	DO231744	LINC	ICGC	VFMYPE	LIG_APCC_ABBA_1	803:808	Mutation rewiring degron network	0.1944
p.L798Q	DO231744	LINC	ICGC	KVFMYPE	LIG_APCC_ABBAyCdc20_2	802:808	Mutation rewiring degron network	0.2222
p.S2211A	DO231719	LINC	ICGC	ATSTS	DEG_SPOP_SBC_1	2218:2222	Mutation rewiring degron network	0.1389
p.R1493K	DO51407	PRAD	ICGC	SEESVLSVPEL	DEG_COP1_1	1480:1490	Mutation rewiring degron network	0.25
p.E1395K	DO229446	SKCA	ICGC	PTKTPSSS	DEG_SCF_FBW7_1	1386:1393	Mutation rewiring degron network	0.2778
p.A1023T	DO229542	UTCA	ICGC	PGKTPARS	DEG_SCF_FBW7_1	1018:1025	Mutation altering degron motif	0.6028
p.A817V	SIDM01247	Burkitt's Lymphoma	GDSC	VFMYPE	LIG_APCC_ABBA_1	803:808	Mutation rewiring degron network	0.0833
p.A817V	SIDM01247	Burkitt's Lymphoma	GDSC	KVFMYPE	LIG_APCC_ABBAyCdc20_2	802:808	Mutation rewiring degron network	0.0833
p.A817V	SIDM01127	Non-Small Cell Lung Carcinoma	GDSC	VFMYPE	LIG_APCC_ABBA_1	803:808	Mutation rewiring degron network	0.0833
p.A817V	SIDM01127	Non-Small Cell Lung Carcinoma	GDSC	KVFMYPE	LIG_APCC_ABBAyCdc20_2	802:808	Mutation rewiring degron network	0.0833
p.A817V	ACH-000628	Lung Cancer	CCLE	VFMYPE	LIG_APCC_ABBA_1	803:808	Mutation rewiring degron network	0.0833
p.A817V	ACH-000628	Lung Cancer	CCLE	KVFMYPE	LIG_APCC_ABBAyCdc20_2	802:808	Mutation rewiring degron network	0.0833
p.A817V	ACH-002300	Lymphoma	CCLE	VFMYPE	LIG_APCC_ABBA_1	803:808	Mutation rewiring degron network	0.0833
p.A817V	ACH-002300	Lymphoma	CCLE	KVFMYPE	LIG_APCC_ABBAyCdc20_2	802:808	Mutation rewiring degron network	0.0833
p.A817V	NCI-H596	lung	COSMIC	VFMYPE	LIG_APCC_ABBA_1	803:808	Mutation rewiring degron network	0.0833
p.A817V	NCI-H596	lung	COSMIC	KVFMYPE	LIG_APCC_ABBAyCdc20_2	802:808	Mutation rewiring degron network	0.0833
p.A817V	Ramos-2G6-4C10	haematopoietic and lymphoid tissue	COSMIC	VFMYPE	LIG_APCC_ABBA_1	803:808	Mutation rewiring degron network	0.0833
p.A817V	Ramos-2G6-4C10	haematopoietic and lymphoid tissue	COSMIC	KVFMYPE	LIG_APCC_ABBAyCdc20_2	802:808	Mutation rewiring degron network	0.0833
p.R1024Q	SIDM00181	Bladder Carcinoma	GDSC	PGKTPARS	DEG_SCF_FBW7_1	1018:1025	Mutation altering degron motif	0.6218
p.R1024Q	SIDM01646	Non-Cancerous	GDSC	PGKTPARS	DEG_SCF_FBW7_1	1018:1025	Mutation altering degron motif	0.6218
p.R1024Q	SIDM01778	B-Cell Non-Hodgkin's Lymphoma	GDSC	PGKTPARS	DEG_SCF_FBW7_1	1018:1025	Mutation altering degron motif	0.6218
p.R1024Q	SIDM01525	Acute Myeloid Leukemia	GDSC	PGKTPARS	DEG_SCF_FBW7_1	1018:1025	Mutation altering degron motif	0.6218
p.S1015G	SIDM01677	Non-Small Cell Lung Carcinoma	GDSC	PGKTPARS	DEG_SCF_FBW7_1	1018:1025	Mutation rewiring degron network	0.25
p.S1015G	ACH-000845	Lung Cancer	CCLE	PGKTPARS	DEG_SCF_FBW7_1	1018:1025	Mutation rewiring degron network	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GON4L

UniProt ID: Q3T8J9

Entrez ID: 54856

Protein name: GON-4-like protein (GON-4 homolog)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GON4L in