DegronMD: protein-targeted degradation, mutation and drug response to degrons
Home
(current)
Browse
Proteins/Degrons
Mutations
Drug response
Network-rewiring
Drug resistance
Search
Tutorial
Download
Contact
Links
BSML
CPH
CGC
Degron:
VFMYPE
Uniprot ID:
Q3T8J9
Source protein:
GON-4-like protein
Source gene:
GON4L
Class:
LIG_APCC_ABBA_1
Location:
803:808
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.7243
ASA_SCORE:
34.65
COIL:
0.6115
CONS_SCORE:
0.6534
DSS_SCORE:
0.0239
HELIX:
0.2673
FCONS_SCORE:
1.3512
RIG_SCORE:
0.9166
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.S801R
TCGA-A6-3809
COAD
TCGA
VFMYPE
LIG_APCC_ABBA_1
0.2778
p.S801R
DO8722
COAD
ICGC
VFMYPE
LIG_APCC_ABBA_1
0.2778
p.K818N
TCGA-B5-A11E
UCEC
TCGA
VFMYPE
LIG_APCC_ABBA_1
0.1667
p.K818N
DO41644
UCEC
ICGC
VFMYPE
LIG_APCC_ABBA_1
0.1667
p.V812M
TCGA-B5-A3FA
UCEC
TCGA
VFMYPE
LIG_APCC_ABBA_1
0.2222
p.V812M
DO52402
UCEC
ICGC
VFMYPE
LIG_APCC_ABBA_1
0.2222
p.P811S
TCGA-EE-A2MR
SKCM
TCGA
VFMYPE
LIG_APCC_ABBA_1
0.25
p.P811S
DO37819
SKCM
ICGC
VFMYPE
LIG_APCC_ABBA_1
0.25
p.E808K
TCGA-SY-A9G5
BLCA
TCGA
VFMYPE
LIG_APCC_ABBA_1
0.7022
p.E808K
DO51906
BLCA
ICGC
VFMYPE
LIG_APCC_ABBA_1
0.7022
p.T800K
DO229022
LICA
ICGC
VFMYPE
LIG_APCC_ABBA_1
0.25
p.T800K
DO229232
THCA
ICGC
VFMYPE
LIG_APCC_ABBA_1
0.25
p.A799D
DO229009
LICA
ICGC
VFMYPE
LIG_APCC_ABBA_1
0.2222
p.L798Q
DO231744
LINC
ICGC
VFMYPE
LIG_APCC_ABBA_1
0.1944
p.A817V
SIDM01247
Burkitt's Lymphoma
GDSC
VFMYPE
LIG_APCC_ABBA_1
0.0833
p.A817V
SIDM01127
Non-Small Cell Lung Carcinoma
GDSC
VFMYPE
LIG_APCC_ABBA_1
0.0833
p.A817V
ACH-000628
Lung Cancer
CCLE
VFMYPE
LIG_APCC_ABBA_1
0.0833
p.A817V
ACH-002300
Lymphoma
CCLE
VFMYPE
LIG_APCC_ABBA_1
0.0833
p.A817V
NCI-H596
lung
COSMIC
VFMYPE
LIG_APCC_ABBA_1
0.0833
p.A817V
Ramos-2G6-4C10
haematopoietic_and_lymphoid_tissue
COSMIC
VFMYPE
LIG_APCC_ABBA_1
0.0833
Drug responses associated with GON4L mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VFMYPE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q3T8J9
GON-4-like protein
LIG_APCC_ABBA_1
803:808
VFMYPE
APC,CDC20,FZR1
0.7243
More...
Q9H869
YY1-associated protein 1
LIG_APCC_ABBA_1
280:285
VFMYPE
APC,CDC20,FZR1
0.57
More...