DegronMD

Uniprot ID: Q9H869

Source protein: YY1-associated protein 1

Source gene: YY1AP1

Class: LIG_APCC_ABBA_1

Location: 280:285

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.57

ASA_SCORE: 52.0667

COIL: 0.5908

CONS_SCORE: 0.8224

DSS_SCORE: 0.0218

HELIX: 0.345

FCONS_SCORE: 1.1522

RIG_SCORE: 0.9122

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q283R	TCGA-55-5899	LUAD	TCGA	VFMYPE	LIG_APCC_ABBA_1	0.7329
p.L288P	TCGA-B5-A3FC	UCEC	TCGA	VFMYPE	LIG_APCC_ABBA_1	0.25
p.S285C	TCGA-DG-A2KK	CESC	TCGA	VFMYPE	LIG_APCC_ABBA_1	0.7541
p.E277Q	TCGA-P3-A5Q5	HNSC	TCGA	VFMYPE	LIG_APCC_ABBA_1	0.25
p.A272P	DO218998	BLCA	ICGC	VFMYPE	LIG_APCC_ABBA_1	0.1111
p.R273H	DO9010	COAD	ICGC	VFMYPE	LIG_APCC_ABBA_1	0.1389
p.R273H	IST-MES1	pleura	COSMIC	VFMYPE	LIG_APCC_ABBA_1	0.1389
p.M284K	DO20893	KIRP	ICGC	VFMYPE	LIG_APCC_ABBA_1	0.8062
p.R273S	DO228952	LICA	ICGC	VFMYPE	LIG_APCC_ABBA_1	0.1389
p.R273S	DO229009	LICA	ICGC	VFMYPE	LIG_APCC_ABBA_1	0.1389
p.N283K	DO229032	LICA	ICGC	VFMYPE	LIG_APCC_ABBA_1	0.6918
p.N293S	SIDM02026	Colorectal Carcinoma	GDSC	VFMYPE	LIG_APCC_ABBA_1	0.5556
p.N272S	ACH-000978	Endometrial/Uterine Cancer	CCLE	VFMYPE	LIG_APCC_ABBA_1	0.1111
p.N272S	EN	endometrium	COSMIC	VFMYPE	LIG_APCC_ABBA_1	0.1111
p.R273C	NCI-H630	large_intestine	COSMIC	VFMYPE	LIG_APCC_ABBA_1	0.1389
p.P287A	MDA-MB-330	breast	COSMIC	VFMYPE	LIG_APCC_ABBA_1	0.2778
p.N283S	EN	endometrium	COSMIC	VFMYPE	LIG_APCC_ABBA_1	0.7069

DegronMD: protein-targeted degradation, mutation and drug response to degrons