DegronMD

Uniprot ID: Q3T8J9

Source protein: GON-4-like protein

Source gene: GON4L

Class: DEG_COP1_1

Location: 1480:1490

E3 ligase: COP1

DEGRON score: 0.8433

ASA_SCORE: 88.0818

COIL: 0.6295

CONS_SCORE: 0.4598

DSS_SCORE: 0.7146

HELIX: 0.3497

FCONS_SCORE: 1.1473

RIG_SCORE: 0.6984

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D1474Y	TCGA-AP-A1DV	UCEC	TCGA	SEESVLSVPEL	DEG_COP1_1	0.1667
p.D1474Y	DO43186	UCEC	ICGC	SEESVLSVPEL	DEG_COP1_1	0.1667
p.S1477L	TCGA-BH-A1FL	BRCA	TCGA	SEESVLSVPEL	DEG_COP1_1	0.25
p.S1477L	DO5221	BRCA	ICGC	SEESVLSVPEL	DEG_COP1_1	0.25
p.S1483F	TCGA-DK-AA6X	BLCA	TCGA	SEESVLSVPEL	DEG_COP1_1	0.7982
p.S1483F	DO51873	BLCA	ICGC	SEESVLSVPEL	DEG_COP1_1	0.7982
p.E1481Q	TCGA-IR-A3LK	CESC	TCGA	SEESVLSVPEL	DEG_COP1_1	0.5633
p.E1481Q	DO44299	CESC	ICGC	SEESVLSVPEL	DEG_COP1_1	0.5633
p.D1471N	TCGA-LN-A9FQ	ESCA	TCGA	SEESVLSVPEL	DEG_COP1_1	0.0833
p.E1472K	TCGA-ZF-AA54	BLCA	TCGA	SEESVLSVPEL	DEG_COP1_1	0.1111
p.E1472K	DO219098	BLCA	ICGC	SEESVLSVPEL	DEG_COP1_1	0.1111
p.Q1470K	DO228948	LICA	ICGC	SEESVLSVPEL	DEG_COP1_1	0.0556
p.V1500A	DO22845	LIHC	ICGC	SEESVLSVPEL	DEG_COP1_1	0.0556
p.R1493K	DO51407	PRAD	ICGC	SEESVLSVPEL	DEG_COP1_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q3T8J9	GON-4-like protein	DEG_COP1_1	1480:1490	SEESVLSVPEL	COP1	0.8433	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons