DegronMD

Uniprot ID: Q3T8J9

Source protein: GON-4-like protein

Source gene: GON4L

Class: LIG_APCC_ABBAyCdc20_2

Location: 802:808

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8459

ASA_SCORE: 46.0571

COIL: 0.6381

CONS_SCORE: 0.6398

DSS_SCORE: 0.0259

HELIX: 0.2527

FCONS_SCORE: 1.3371

RIG_SCORE: 0.9153

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S801R	TCGA-A6-3809	COAD	TCGA	KVFMYPE	LIG_APCC_ABBAyCdc20_2	0.3056
p.S801R	DO8722	COAD	ICGC	KVFMYPE	LIG_APCC_ABBAyCdc20_2	0.3056
p.K818N	TCGA-B5-A11E	UCEC	TCGA	KVFMYPE	LIG_APCC_ABBAyCdc20_2	0.1667
p.K818N	DO41644	UCEC	ICGC	KVFMYPE	LIG_APCC_ABBAyCdc20_2	0.1667
p.V812M	TCGA-B5-A3FA	UCEC	TCGA	KVFMYPE	LIG_APCC_ABBAyCdc20_2	0.2222
p.V812M	DO52402	UCEC	ICGC	KVFMYPE	LIG_APCC_ABBAyCdc20_2	0.2222
p.P811S	TCGA-EE-A2MR	SKCM	TCGA	KVFMYPE	LIG_APCC_ABBAyCdc20_2	0.25
p.P811S	DO37819	SKCM	ICGC	KVFMYPE	LIG_APCC_ABBAyCdc20_2	0.25
p.E808K	TCGA-SY-A9G5	BLCA	TCGA	KVFMYPE	LIG_APCC_ABBAyCdc20_2	0.7022
p.E808K	DO51906	BLCA	ICGC	KVFMYPE	LIG_APCC_ABBAyCdc20_2	0.7022
p.T800K	DO229022	LICA	ICGC	KVFMYPE	LIG_APCC_ABBAyCdc20_2	0.2778
p.T800K	DO229232	THCA	ICGC	KVFMYPE	LIG_APCC_ABBAyCdc20_2	0.2778
p.A799D	DO229009	LICA	ICGC	KVFMYPE	LIG_APCC_ABBAyCdc20_2	0.25
p.L798Q	DO231744	LINC	ICGC	KVFMYPE	LIG_APCC_ABBAyCdc20_2	0.2222
p.A817V	SIDM01247	Burkitt's Lymphoma	GDSC	KVFMYPE	LIG_APCC_ABBAyCdc20_2	0.0833
p.A817V	SIDM01127	Non-Small Cell Lung Carcinoma	GDSC	KVFMYPE	LIG_APCC_ABBAyCdc20_2	0.0833
p.A817V	ACH-000628	Lung Cancer	CCLE	KVFMYPE	LIG_APCC_ABBAyCdc20_2	0.0833
p.A817V	ACH-002300	Lymphoma	CCLE	KVFMYPE	LIG_APCC_ABBAyCdc20_2	0.0833
p.A817V	NCI-H596	lung	COSMIC	KVFMYPE	LIG_APCC_ABBAyCdc20_2	0.0833
p.A817V	Ramos-2G6-4C10	haematopoietic_and_lymphoid_tissue	COSMIC	KVFMYPE	LIG_APCC_ABBAyCdc20_2	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons