DegronMD

Uniprot ID: Q9H869

Source protein: YY1-associated protein 1

Source gene: YY1AP1

Class: LIG_APCC_ABBAyCdc20_2

Location: 279:285

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6275

ASA_SCORE: 62.8

COIL: 0.5703

CONS_SCORE: 0.8385

DSS_SCORE: 0.0243

HELIX: 0.369

FCONS_SCORE: 1.197

RIG_SCORE: 0.9111

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M284K	DO20893	KIRP	ICGC	KVFMYPE	LIG_APCC_ABBAyCdc20_2	0.8062
p.S285C	TCGA-DG-A2KK	CESC	TCGA	KVFMYPE	LIG_APCC_ABBAyCdc20_2	0.7541
p.Q283R	TCGA-55-5899	LUAD	TCGA	KVFMYPE	LIG_APCC_ABBAyCdc20_2	0.7329
p.G279E	TCGA-GS-A9TZ	DLBC	TCGA	KVFMYPE	LIG_APCC_ABBAyCdc20_2	0.7199
p.N283S	EN	endometrium	COSMIC	KVFMYPE	LIG_APCC_ABBAyCdc20_2	0.7069
p.N283K	DO229032	LICA	ICGC	KVFMYPE	LIG_APCC_ABBAyCdc20_2	0.6918
p.N293S	SIDM02026	Colorectal Carcinoma	GDSC	KVFMYPE	LIG_APCC_ABBAyCdc20_2	0.5556
p.E277Q	TCGA-P3-A5Q5	HNSC	TCGA	KVFMYPE	LIG_APCC_ABBAyCdc20_2	0.2778
p.P287A	MDA-MB-330	breast	COSMIC	KVFMYPE	LIG_APCC_ABBAyCdc20_2	0.2778
p.L288P	TCGA-B5-A3FC	UCEC	TCGA	KVFMYPE	LIG_APCC_ABBAyCdc20_2	0.25
p.S269N	TCGA-BG-A2L7	UCEC	TCGA	KVFMYPE	LIG_APCC_ABBAyCdc20_2	0.1667
p.R273H	DO9010	COAD	ICGC	KVFMYPE	LIG_APCC_ABBAyCdc20_2	0.1667
p.R273H	IST-MES1	pleura	COSMIC	KVFMYPE	LIG_APCC_ABBAyCdc20_2	0.1667
p.R273S	DO228952	LICA	ICGC	KVFMYPE	LIG_APCC_ABBAyCdc20_2	0.1667
p.R273S	DO229009	LICA	ICGC	KVFMYPE	LIG_APCC_ABBAyCdc20_2	0.1667
p.K269N	ACH-000910	Breast Cancer	CCLE	KVFMYPE	LIG_APCC_ABBAyCdc20_2	0.1667
p.K269N	MDA-MB-453	breast	COSMIC	KVFMYPE	LIG_APCC_ABBAyCdc20_2	0.1667
p.R273C	NCI-H630	large_intestine	COSMIC	KVFMYPE	LIG_APCC_ABBAyCdc20_2	0.1667
p.A272P	DO218998	BLCA	ICGC	KVFMYPE	LIG_APCC_ABBAyCdc20_2	0.1389
p.N272S	ACH-000978	Endometrial/Uterine Cancer	CCLE	KVFMYPE	LIG_APCC_ABBAyCdc20_2	0.1389
p.N272S	EN	endometrium	COSMIC	KVFMYPE	LIG_APCC_ABBAyCdc20_2	0.1389

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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DegronMD: protein-targeted degradation, mutation and drug response to degrons