DegronMD

Uniprot ID: Q3T8J9

Source protein: GON-4-like protein

Source gene: GON4L

Class: DEG_APCC_DBOX_1

Location: 1298:1306

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9965

ASA_SCORE: 74.6889

COIL: 0.7422

CONS_SCORE: 0.313

DSS_SCORE: 0.5716

HELIX: 0.1623

FCONS_SCORE: 1.1152

RIG_SCORE: 0.7183

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V1292I	TCGA-62-A46O	LUAD	TCGA	GRQALEPLP	DEG_APCC_DBOX_1	0.1667
p.V1292I	DO26240	LUAD	ICGC	GRQALEPLP	DEG_APCC_DBOX_1	0.1667
p.V1292I	SIDM01314	Colorectal Carcinoma	GDSC	GRQALEPLP	DEG_APCC_DBOX_1	0.1667
p.R1289C	TCGA-D1-A0ZO	UCEC	TCGA	GRQALEPLP	DEG_APCC_DBOX_1	0.0833
p.R1289C	DO41927	UCEC	ICGC	GRQALEPLP	DEG_APCC_DBOX_1	0.0833
p.G1308D	TCGA-D5-6928	COAD	TCGA	GRQALEPLP	DEG_APCC_DBOX_1	0.2778
p.G1308D	DO7776	COAD	ICGC	GRQALEPLP	DEG_APCC_DBOX_1	0.2778
p.G1308S	TCGA-DU-6407	LGG	TCGA	GRQALEPLP	DEG_APCC_DBOX_1	0.2778
p.G1308S	DO22295	LGG	ICGC	GRQALEPLP	DEG_APCC_DBOX_1	0.2778
p.P1306S	TCGA-EE-A17X	SKCM	TCGA	GRQALEPLP	DEG_APCC_DBOX_1	0.5641
p.P1306S	DO37931	SKCM	ICGC	GRQALEPLP	DEG_APCC_DBOX_1	0.5641

DegronMD: protein-targeted degradation, mutation and drug response to degrons