DegronMD

Uniprot ID: Q9H869

Source protein: YY1-associated protein 1

Source gene: YY1AP1

Class: DEG_APCC_DBOX_1

Location: 754:762

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9991

ASA_SCORE: 75.8222

COIL: 0.7688

CONS_SCORE: 0.7367

DSS_SCORE: 0.5678

HELIX: 0.0309

FCONS_SCORE: 1.1338

RIG_SCORE: 0.7246

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P745S	TCGA-94-A5I6	LUSC	TCGA	GRQALEPLP	DEG_APCC_DBOX_1	0.0833
p.S760Y	TCGA-BS-A0UF	UCEC	TCGA	GRQALEPLP	DEG_APCC_DBOX_1	0.712
p.V761L	TCGA-LL-A7SZ	BRCA	TCGA	GRQALEPLP	DEG_APCC_DBOX_1	0.6765
p.E744A	DO10244	COAD	ICGC	GRQALEPLP	DEG_APCC_DBOX_1	0.0556
p.S747G	DO7977	COAD	ICGC	GRQALEPLP	DEG_APCC_DBOX_1	0.1389
p.L750I	DO219773	UCEC	ICGC	GRQALEPLP	DEG_APCC_DBOX_1	0.6667
p.D758G	SW872	soft_tissue	COSMIC	GRQALEPLP	DEG_APCC_DBOX_1	0.7198
p.M755V	NCI-H3122	lung	COSMIC	GRQALEPLP	DEG_APCC_DBOX_1	0.7208
p.P760Q	SK-UT-1	soft_tissue	COSMIC	GRQALEPLP	DEG_APCC_DBOX_1	0.5924
p.E753K	THP-1	haematopoietic_and_lymphoid_tissue	COSMIC	GRQALEPLP	DEG_APCC_DBOX_1	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons