DegronMD

Uniprot ID: Q3T8J9

Source protein: GON-4-like protein

Source gene: GON4L

Class: DEG_SCF_FBW7_1

Location: 1018:1025

E3 ligase: FBXW7

DEGRON score: 0.9348

ASA_SCORE: 83.0875

COIL: 0.9109

CONS_SCORE: 0.2775

DSS_SCORE: 0.7543

HELIX: 0.029

FCONS_SCORE: 0.8941

RIG_SCORE: 0.5409

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1011C	TCGA-5N-A9KI	BLCA	TCGA	PGKTPARS	DEG_SCF_FBW7_1	0.1389
p.S1011C	DO223513	BLCA	ICGC	PGKTPARS	DEG_SCF_FBW7_1	0.1389
p.F1016S	TCGA-AA-3984	COAD	TCGA	PGKTPARS	DEG_SCF_FBW7_1	0.2778
p.F1016S	DO9002	COAD	ICGC	PGKTPARS	DEG_SCF_FBW7_1	0.2778
p.S1009I	TCGA-AP-A0LM	UCEC	TCGA	PGKTPARS	DEG_SCF_FBW7_1	0.5278
p.S1009I	DO43306	UCEC	ICGC	PGKTPARS	DEG_SCF_FBW7_1	0.5278
p.P1010L	TCGA-ER-A199	SKCM	TCGA	PGKTPARS	DEG_SCF_FBW7_1	0.1111
p.P1010L	DO47395	SKCM	ICGC	PGKTPARS	DEG_SCF_FBW7_1	0.1111
p.P1010L	SIDM00374	B-Cell Non-Hodgkin's Lymphoma	GDSC	PGKTPARS	DEG_SCF_FBW7_1	0.1111
p.P1010L	SIDM00589	Oral Cavity Carcinoma	GDSC	PGKTPARS	DEG_SCF_FBW7_1	0.1111
p.P1010L	SIDM00564	Ovarian Carcinoma	GDSC	PGKTPARS	DEG_SCF_FBW7_1	0.1111
p.P1010L	SIDM00986	Head and Neck Carcinoma	GDSC	PGKTPARS	DEG_SCF_FBW7_1	0.1111
p.P1010L	SIDM01574	Plasma Cell Myeloma	GDSC	PGKTPARS	DEG_SCF_FBW7_1	0.1111
p.P1010L	ACH-000527	Ovarian Cancer	CCLE	PGKTPARS	DEG_SCF_FBW7_1	0.1111
p.P1010L	ACH-000548	Head and Neck Cancer	CCLE	PGKTPARS	DEG_SCF_FBW7_1	0.1111
p.P1010L	ACH-000588	Myeloma	CCLE	PGKTPARS	DEG_SCF_FBW7_1	0.1111
p.P1010L	ACH-000778	Head and Neck Cancer	CCLE	PGKTPARS	DEG_SCF_FBW7_1	0.1111
p.P1010L	ACH-002062	Lymphoma	CCLE	PGKTPARS	DEG_SCF_FBW7_1	0.1111
p.P1010L	OVISE	ovary	COSMIC	PGKTPARS	DEG_SCF_FBW7_1	0.1111
p.P1010L	HSC-3	upper_aerodigestive_tract	COSMIC	PGKTPARS	DEG_SCF_FBW7_1	0.1111
p.P1010L	BHY	upper_aerodigestive_tract	COSMIC	PGKTPARS	DEG_SCF_FBW7_1	0.1111
p.P1010L	SLVL	haematopoietic_and_lymphoid_tissue	COSMIC	PGKTPARS	DEG_SCF_FBW7_1	0.1111
p.P1031H	TCGA-FI-A2F4	UCEC	TCGA	PGKTPARS	DEG_SCF_FBW7_1	0.1667
p.P1031H	DO43434	UCEC	ICGC	PGKTPARS	DEG_SCF_FBW7_1	0.1667
p.P1031S	TCGA-QC-A7B5	SARC	TCGA	PGKTPARS	DEG_SCF_FBW7_1	0.1667
p.P1031S	DO220239	SARC	ICGC	PGKTPARS	DEG_SCF_FBW7_1	0.1667
p.P1018T	DO229019	LICA	ICGC	PGKTPARS	DEG_SCF_FBW7_1	0.7031
p.A1023T	DO229542	UTCA	ICGC	PGKTPARS	DEG_SCF_FBW7_1	0.6028
p.R1024Q	SIDM00181	Bladder Carcinoma	GDSC	PGKTPARS	DEG_SCF_FBW7_1	0.6218
p.R1024Q	SIDM01646	Non-Cancerous	GDSC	PGKTPARS	DEG_SCF_FBW7_1	0.6218
p.R1024Q	SIDM01778	B-Cell Non-Hodgkin's Lymphoma	GDSC	PGKTPARS	DEG_SCF_FBW7_1	0.6218
p.R1024Q	SIDM01525	Acute Myeloid Leukemia	GDSC	PGKTPARS	DEG_SCF_FBW7_1	0.6218
p.S1015G	SIDM01677	Non-Small Cell Lung Carcinoma	GDSC	PGKTPARS	DEG_SCF_FBW7_1	0.25
p.S1015G	ACH-000845	Lung Cancer	CCLE	PGKTPARS	DEG_SCF_FBW7_1	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PGKTPARS

Degron related mutations and impact score

Drug responses associated with GON4L mutations

All proteins holding degron of PGKTPARS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q3T8J9	GON-4-like protein	DEG_SCF_FBW7_1	1018:1025	PGKTPARS	FBXW7	0.9348	More...