DegronMD

Uniprot ID: Q3T8J9

Source protein: GON-4-like protein

Source gene: GON4L

Class: DEG_SCF_FBW7_1

Location: 1386:1393

E3 ligase: FBXW7

DEGRON score: 0.9242

ASA_SCORE: 98.1125

COIL: 0.9345

CONS_SCORE: 0.2858

DSS_SCORE: 0.8772

HELIX: 0.0418

FCONS_SCORE: 1.048

RIG_SCORE: 0.5357

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1397S	TCGA-43-5668	LUSC	TCGA	PTKTPSSS	DEG_SCF_FBW7_1	0.2222
p.P1397S	DO26608	LUSC	ICGC	PTKTPSSS	DEG_SCF_FBW7_1	0.2222
p.D1398H	TCGA-55-A4DF	LUAD	TCGA	PTKTPSSS	DEG_SCF_FBW7_1	0.1944
p.D1398H	DO45318	LUAD	ICGC	PTKTPSSS	DEG_SCF_FBW7_1	0.1944
p.E1399K	TCGA-DR-A0ZM	CESC	TCGA	PTKTPSSS	DEG_SCF_FBW7_1	0.1667
p.E1399K	DO6254	CESC	ICGC	PTKTPSSS	DEG_SCF_FBW7_1	0.1667
p.G1400R	TCGA-PL-A8LV	BRCA	TCGA	PTKTPSSS	DEG_SCF_FBW7_1	0.1389
p.G1400R	DO51215	BRCA	ICGC	PTKTPSSS	DEG_SCF_FBW7_1	0.1389
p.K1379N	DO223016	ESCA	ICGC	PTKTPSSS	DEG_SCF_FBW7_1	0.25
p.Q1378R	DO23182	LINC	ICGC	PTKTPSSS	DEG_SCF_FBW7_1	0.1111
p.E1395K	DO229446	SKCA	ICGC	PTKTPSSS	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q3T8J9	GON-4-like protein	DEG_SCF_FBW7_1	1386:1393	PTKTPSSS	FBXW7	0.9242	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons