DegronMD - Q96T17(MAP7D2)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S222Y	TCGA-AP-A1DV	UCEC	TCGA	ATSTS	DEG_SPOP_SBC_1	229:233	Mutation rewiring degron network	0.1389
p.S222Y	DO43186	UCEC	ICGC	ATSTS	DEG_SPOP_SBC_1	229:233	Mutation rewiring degron network	0.1389
p.R227S	TCGA-D1-A177	UCEC	TCGA	ATSTS	DEG_SPOP_SBC_1	229:233	Mutation rewiring degron network	0.2778
p.R227S	DO42528	UCEC	ICGC	ATSTS	DEG_SPOP_SBC_1	229:233	Mutation rewiring degron network	0.2778
p.V240L	TCGA-GN-A262	SKCM	TCGA	ATSTS	DEG_SPOP_SBC_1	229:233	Mutation rewiring degron network	0.1389
p.V240L	DO37515	SKCM	ICGC	ATSTS	DEG_SPOP_SBC_1	229:233	Mutation rewiring degron network	0.1389
p.T232A	DO52549	BRCA	ICGC	ATSTS	DEG_SPOP_SBC_1	229:233	Mutation altering degron motif	0.7139
p.R222Q	DO10172	COAD	ICGC	ATSTS	DEG_SPOP_SBC_1	229:233	Mutation rewiring degron network	0.1389
p.R222Q	DO230344	COCA	ICGC	ATSTS	DEG_SPOP_SBC_1	229:233	Mutation rewiring degron network	0.1389
p.R222Q	DO47590	SKCM	ICGC	ATSTS	DEG_SPOP_SBC_1	229:233	Mutation rewiring degron network	0.1389
p.G234W	DO233235	GACA	ICGC	ATSTS	DEG_SPOP_SBC_1	229:233	Mutation rewiring degron network	0.3056
p.A236V	DO233839	GACA	ICGC	ATSTS	DEG_SPOP_SBC_1	229:233	Mutation rewiring degron network	0.25
p.D239Y	DO10880	GBM	ICGC	ATSTS	DEG_SPOP_SBC_1	229:233	Mutation rewiring degron network	0.1667
p.G236V	DO23708	LUAD	ICGC	ATSTS	DEG_SPOP_SBC_1	229:233	Mutation rewiring degron network	0.25
p.K242E	DO47272	SKCM	ICGC	ATSTS	DEG_SPOP_SBC_1	229:233	Mutation substituting flanking lysine	0.1944
p.R222G	DO219763	UCEC	ICGC	ATSTS	DEG_SPOP_SBC_1	229:233	Mutation rewiring degron network	0.1389
p.S233Y	DO41572	UCEC	ICGC	ATSTS	DEG_SPOP_SBC_1	229:233	Mutation altering degron motif	0.712
p.L232I	SIDM00390	T-Cell Non-Hodgkin's Lymphoma	GDSC	ATSTS	DEG_SPOP_SBC_1	229:233	Mutation altering degron motif	0.7174
p.L232I	ACH-000664	Lymphoma	CCLE	ATSTS	DEG_SPOP_SBC_1	229:233	Mutation altering degron motif	0.7174
p.L232I	SU-DHL-1	haematopoietic and lymphoid tissue	COSMIC	ATSTS	DEG_SPOP_SBC_1	229:233	Mutation altering degron motif	0.7174
p.V230L	SIDM00611	Kidney Carcinoma	GDSC	ATSTS	DEG_SPOP_SBC_1	229:233	Mutation altering degron motif	0.6765
p.V230L	ACH-000684	Kidney Cancer	CCLE	ATSTS	DEG_SPOP_SBC_1	229:233	Mutation altering degron motif	0.6765
p.V230L	KMRC-1	kidney	COSMIC	ATSTS	DEG_SPOP_SBC_1	229:233	Mutation altering degron motif	0.6765
p.A229V	CW-2	large intestine	COSMIC	ATSTS	DEG_SPOP_SBC_1	229:233	Mutation altering degron motif	0.5825
p.T230I	SCC-25	upper aerodigestive tract	COSMIC	ATSTS	DEG_SPOP_SBC_1	229:233	Mutation altering degron motif	0.5966

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MAP7D2

UniProt ID: Q96T17

Entrez ID: 256714

Protein name: MAP7 domain-containing protein 2

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MAP7D2 in