DegronMD

Uniprot ID: Q96T17

Source protein: MAP7 domain-containing protein 2

Source gene: MAP7D2

Class: DEG_SPOP_SBC_1

Location: 229:233

E3 ligase: SPOP

DEGRON score: 0.9487

ASA_SCORE: 83.36

COIL: 0.884

CONS_SCORE: 0.4689

DSS_SCORE: 0.6042

HELIX: 0.0814

FCONS_SCORE: 0.9266

RIG_SCORE: 0.6349

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S222Y	TCGA-AP-A1DV	UCEC	TCGA	ATSTS	DEG_SPOP_SBC_1	0.1389
p.S222Y	DO43186	UCEC	ICGC	ATSTS	DEG_SPOP_SBC_1	0.1389
p.R227S	TCGA-D1-A177	UCEC	TCGA	ATSTS	DEG_SPOP_SBC_1	0.2778
p.R227S	DO42528	UCEC	ICGC	ATSTS	DEG_SPOP_SBC_1	0.2778
p.V240L	TCGA-GN-A262	SKCM	TCGA	ATSTS	DEG_SPOP_SBC_1	0.1389
p.V240L	DO37515	SKCM	ICGC	ATSTS	DEG_SPOP_SBC_1	0.1389
p.T232A	DO52549	BRCA	ICGC	ATSTS	DEG_SPOP_SBC_1	0.7139
p.R222Q	DO10172	COAD	ICGC	ATSTS	DEG_SPOP_SBC_1	0.1389
p.R222Q	DO230344	COCA	ICGC	ATSTS	DEG_SPOP_SBC_1	0.1389
p.R222Q	DO47590	SKCM	ICGC	ATSTS	DEG_SPOP_SBC_1	0.1389
p.G234W	DO233235	GACA	ICGC	ATSTS	DEG_SPOP_SBC_1	0.3056
p.A236V	DO233839	GACA	ICGC	ATSTS	DEG_SPOP_SBC_1	0.25
p.D239Y	DO10880	GBM	ICGC	ATSTS	DEG_SPOP_SBC_1	0.1667
p.G236V	DO23708	LUAD	ICGC	ATSTS	DEG_SPOP_SBC_1	0.25
p.K242E	DO47272	SKCM	ICGC	ATSTS	DEG_SPOP_SBC_1	0.1944
p.R222G	DO219763	UCEC	ICGC	ATSTS	DEG_SPOP_SBC_1	0.1389
p.S233Y	DO41572	UCEC	ICGC	ATSTS	DEG_SPOP_SBC_1	0.712
p.L232I	SIDM00390	T-Cell Non-Hodgkin's Lymphoma	GDSC	ATSTS	DEG_SPOP_SBC_1	0.7174
p.L232I	ACH-000664	Lymphoma	CCLE	ATSTS	DEG_SPOP_SBC_1	0.7174
p.L232I	SU-DHL-1	haematopoietic_and_lymphoid_tissue	COSMIC	ATSTS	DEG_SPOP_SBC_1	0.7174
p.V230L	SIDM00611	Kidney Carcinoma	GDSC	ATSTS	DEG_SPOP_SBC_1	0.6765
p.V230L	ACH-000684	Kidney Cancer	CCLE	ATSTS	DEG_SPOP_SBC_1	0.6765
p.V230L	KMRC-1	kidney	COSMIC	ATSTS	DEG_SPOP_SBC_1	0.6765
p.A229V	CW-2	large_intestine	COSMIC	ATSTS	DEG_SPOP_SBC_1	0.5825
p.T230I	SCC-25	upper_aerodigestive_tract	COSMIC	ATSTS	DEG_SPOP_SBC_1	0.5966

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43167	Zinc finger and BTB domain-containing protein 24	DEG_SPOP_SBC_1	661:665	ATSTS	SPOP	0.8818	More...
O75061	Putative tyrosine-protein phosphatase auxilin	DEG_SPOP_SBC_1	564:568	ATSTS	SPOP	0.9989	More...
P51826	AF4/FMR2 family member 3	DEG_SPOP_SBC_1	846:850	ATSTS	SPOP	0.9984	More...
Q12830	Nucleosome-remodeling factor subunit BPTF	DEG_SPOP_SBC_1	2250:2254	ATSTS	SPOP	0.9964	More...
Q13164	Mitogen-activated protein kinase 7	DEG_SPOP_SBC_1	658:662	ATSTS	SPOP	0.6439	More...
Q3T8J9	GON-4-like protein	DEG_SPOP_SBC_1	2218:2222	ATSTS	SPOP	0.6171	More...
Q6W4X9	Mucin-6	DEG_SPOP_SBC_1	1706:1710	ATSTS	SPOP	0.8956	More...
Q70CQ4	Ubiquitin carboxyl-terminal hydrolase 31	DEG_SPOP_SBC_1	1170:1174	ATSTS	SPOP	0.9971	More...
Q8IYB3	Serine/arginine repetitive matrix protein 1	DEG_SPOP_SBC_1	238:242	ATSTS	SPOP	0.9886	More...
Q96IZ7	Serine/Arginine-related protein 53	DEG_SPOP_SBC_1	263:267	ATSTS	SPOP	0.9754	More...
Q9NQC1	E3 ubiquitin-protein ligase Jade-2	DEG_SPOP_SBC_1	22:26	ATSTS	SPOP	0.9861	More...
Q9NQG7	Hermansky-Pudlak syndrome 4 protein	DEG_SPOP_SBC_1	2:6	ATSTS	SPOP	0.7449	More...
Q9NR71	Neutral ceramidase	DEG_SPOP_SBC_1	701:705	ATSTS	SPOP	0.7751	More...
Q9NZM3	Intersectin-2	DEG_SPOP_SBC_1	840:844	ATSTS	SPOP	0.7206	More...
Q9UKL3	CASP8-associated protein 2	DEG_SPOP_SBC_1	1908:1912	ATSTS	SPOP	0.702	More...
Q9Y520	Protein PRRC2C	DEG_SPOP_SBC_1	2690:2694	ATSTS	SPOP	0.9814	More...
Q9Y5P4	Ceramide transfer protein	DEG_SPOP_SBC_1	145:149	ATSTS	SPOP	0.9864	More...
Q96T17	MAP7 domain-containing protein 2	DEG_SPOP_SBC_1	229:233	ATSTS	SPOP	0.9487	More...
Q9H195	Mucin-3B	DEG_SPOP_SBC_1	26:30	ATSTS	SPOP	0.881	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ATSTS

Degron related mutations and impact score

Drug responses associated with MAP7D2 mutations

All proteins holding degron of ATSTS