DegronMD - Q9NQC1(JADE2)

JADE2

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A27T	TCGA-19-5956	GBM	TCGA	ATSTS	DEG_SPOP_SBC_1	22:26	Mutation rewiring degron network	0.3056
p.C30F	TCGA-AB-2807	LAML	TCGA	ATSTS	DEG_SPOP_SBC_1	22:26	Mutation rewiring degron network	0.2222
p.S31A	TCGA-D1-A103	UCEC	TCGA	ATSTS	DEG_SPOP_SBC_1	22:26	Mutation blocking phosphorylation signal	0.6389
p.V735M	TCGA-DF-A2KU	UCEC	TCGA	KVSLHFD	LIG_APCC_ABBAyCdc20_2	740:746	Mutation rewiring degron network	0.1944
p.P731Q	TCGA-FS-A1ZC	SKCM	TCGA	KVSLHFD	LIG_APCC_ABBAyCdc20_2	740:746	Mutation rewiring degron network	0.0833
p.E737D	TCGA-IR-A3LK	CESC	TCGA	KVSLHFD	LIG_APCC_ABBAyCdc20_2	740:746	Mutation rewiring degron network	0.25
p.R756H	SIDM02072	Colorectal Carcinoma	GDSC	KVSLHFD	LIG_APCC_ABBAyCdc20_2	740:746	Mutation rewiring degron network	0.0556
p.A744T	SIDM00905	Cervical Carcinoma	GDSC	KVSLHFD	LIG_APCC_ABBAyCdc20_2	740:746	Mutation altering degron motif	0.7139
p.A744T	C-4-I	cervix	COSMIC	KVSLHFD	LIG_APCC_ABBAyCdc20_2	740:746	Mutation altering degron motif	0.7139
p.S24P	SIDM00839	Colorectal Carcinoma	GDSC	ATSTS	DEG_SPOP_SBC_1	22:26	Mutation altering degron motif	0.6752
p.S24P	LoVo	large intestine	COSMIC	ATSTS	DEG_SPOP_SBC_1	22:26	Mutation altering degron motif	0.6752
p.A17V	TMK-1	stomach	COSMIC	ATSTS	DEG_SPOP_SBC_1	22:26	Mutation rewiring degron network	0.1944
p.D756G	DG-75	haematopoietic and lymphoid tissue	COSMIC	KVSLHFD	LIG_APCC_ABBAyCdc20_2	740:746	Mutation rewiring degron network	0.0556
p.D755G	DG-75	haematopoietic and lymphoid tissue	COSMIC	KVSLHFD	LIG_APCC_ABBAyCdc20_2	740:746	Mutation rewiring degron network	0.0833

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*NOTE: the Kaplan plots were collected from OncoLnc