DegronMD

Uniprot ID: Q9NQC1

Source protein: E3 ubiquitin-protein ligase Jade-2

Source gene: JADE2

Class: LIG_APCC_ABBAyCdc20_2

Location: 740:746

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5019

ASA_SCORE: 97.9571

COIL: 0.8359

CONS_SCORE: 0.4364

DSS_SCORE: 0.5907

HELIX: 0.0787

FCONS_SCORE: 1.0325

RIG_SCORE: 0.7202

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V735M	TCGA-DF-A2KU	UCEC	TCGA	KVSLHFD	LIG_APCC_ABBAyCdc20_2	0.1944
p.P731Q	TCGA-FS-A1ZC	SKCM	TCGA	KVSLHFD	LIG_APCC_ABBAyCdc20_2	0.0833
p.E737D	TCGA-IR-A3LK	CESC	TCGA	KVSLHFD	LIG_APCC_ABBAyCdc20_2	0.25
p.R756H	SIDM02072	Colorectal Carcinoma	GDSC	KVSLHFD	LIG_APCC_ABBAyCdc20_2	0.0556
p.A744T	SIDM00905	Cervical Carcinoma	GDSC	KVSLHFD	LIG_APCC_ABBAyCdc20_2	0.7139
p.A744T	C-4-I	cervix	COSMIC	KVSLHFD	LIG_APCC_ABBAyCdc20_2	0.7139
p.D756G	DG-75	haematopoietic_and_lymphoid_tissue	COSMIC	KVSLHFD	LIG_APCC_ABBAyCdc20_2	0.0556
p.D755G	DG-75	haematopoietic_and_lymphoid_tissue	COSMIC	KVSLHFD	LIG_APCC_ABBAyCdc20_2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NQC1	E3 ubiquitin-protein ligase Jade-2	LIG_APCC_ABBAyCdc20_2	740:746	KVSLHFD	APC,CDC20,FZR1	0.5019	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons